Artículo
Abstract:
The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. Phentolamine also depressed the frequency. Both findings suggest that catecholamines and endogenous prostaglandins are in some way regulators of the spontaneous motility of the cauda epididymidis. Norepinephrine resulted in the development of a distinct, sustained, tonic contraction without plastic activity, whereas prostaglandins E1, E2, and F(2α) elicited a tonic increase accompanied by frequent, superimposed, phasic contractions. Both oxytocin and vasopressin comparably enhanced epididymal motility, producing contractile responses similar to those observed with prostaglandins. Since the epididymal contractions can influence the time spent by spermatozoa in passing through the ductus epididymidis, the above mentioned compounds could play an important role in spermatozoal transport via modulation of epididymal contractile activity. In addition, such naturally occurring substances might regulate the release of sperm from the last portion of the epididymis into the ductus deferens.
Registro:
| Documento: | Artículo |
| Título: | Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| Autor: | Da Silva Souza, E.M.C.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Cent. Estud. Farmacol. Principios Naturales, Buenos Aires, Argentina |
| Palabras clave: | indometacin; noradrenalin; oxytocin; phentolamine; phentolamine mesylate; prostaglandin; prostaglandin E1; prostaglandin E2; prostaglandin F2 alpha; vasopressin; epididymis; guinea pig; in vitro study; smooth muscle contractility; smooth muscle contraction; theoretical study |
| Año: | 1975 |
| Volumen: | 26 |
| Número: | 12 |
| Página de inicio: | 1250 |
| Página de fin: | 1256 |
| Título revista: | Fertility and Sterility |
| Título revista abreviado: | FERTIL. STERIL. |
| ISSN: | 00150282 |
| CODEN: | FESTA |
| CAS: | indometacin, 53-86-1, 74252-25-8, 7681-54-1; noradrenalin, 1407-84-7, 51-41-2; oxytocin, 50-56-6, 54577-94-5; phentolamine, 50-60-2, 73-05-2; phentolamine mesylate, 65-28-1; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; vasopressin, 11000-17-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza |
Citas:
---------- APA ----------
Da Silva Souza, E.M.C., Gimeno, M.F. & Gimeno, A.L. (1975) . Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis. Fertility and Sterility, 26(12), 1250-1256.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza [ ]
---------- CHICAGO ----------
Da Silva Souza, E.M.C., Gimeno, M.F., Gimeno, A.L. "Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis" . Fertility and Sterility 26, no. 12 (1975) : 1250-1256.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza [ ]
---------- MLA ----------
Da Silva Souza, E.M.C., Gimeno, M.F., Gimeno, A.L. "Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis" . Fertility and Sterility, vol. 26, no. 12, 1975, pp. 1250-1256.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza [ ]
---------- VANCOUVER ----------
Da Silva Souza, E.M.C., Gimeno, M.F., Gimeno, A.L. Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis. FERTIL. STERIL. 1975;26(12):1250-1256.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza [ ]
