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Abstract:

The highly conserved plant aquaporins, known as Plasma membrane Intrinsic Proteins (PIPs), are the main gateways for cell membrane water exchange. Years of research have described in detail the properties of the PIP2 subfamily. However, characterizing the PIP1 subfamily has been difficult due to the failure to localize to the plasma membrane. In addition, the discovery of the PIP1-PIP2 interaction suggested that PIP1 aquaporins could be regulated by a complex posttranslational mechanism that involves trafficking, heteromerization and fine-tuning of channel activity. This review not only considers the evidence and findings but also discusses the complexity of PIP aquaporins. To establish a new benchmark in PIP regulation, we propose to consider PIP1-PIP2 pairs as functional units for the purpose of future research into their physiological roles. © 2015 Federation of European Biochemical Societies.

Registro:

Documento: Artículo
Título:PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?
Autor:Yaneff, A.; Vitali, V.; Amodeo, G.
Filiación:Departamento de Biodiversidad de Biología Experimental, Instituto de Biodiversidad y Biología Experimental (IBBEA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Buenos Aires, Argentina
Palabras clave:Heteromerization; Osmotic permeability; Water channel; aquaporin; plasma membrane Intrinsic protein 1; plasma membrane Intrinsic protein 2; unclassified drug; aquaporin; water; nonhuman; priority journal; protein expression; protein function; protein interaction; protein structure; regulatory mechanism; Review; structure analysis; water transport; animal; gene expression regulation; metabolism; transport at the cellular level; Animals; Aquaporins; Biological Transport; Gene Expression Regulation; Water
Año:2015
Volumen:589
Número:23
Página de inicio:3508
Página de fin:3515
DOI: http://dx.doi.org/10.1016/j.febslet.2015.10.018
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:aquaporin, 215587-75-0; water, 7732-18-5; Aquaporins; Water
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n23_p3508_Yaneff

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Citas:

---------- APA ----------
Yaneff, A., Vitali, V. & Amodeo, G. (2015) . PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?. FEBS Letters, 589(23), 3508-3515.
http://dx.doi.org/10.1016/j.febslet.2015.10.018
---------- CHICAGO ----------
Yaneff, A., Vitali, V., Amodeo, G. "PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?" . FEBS Letters 589, no. 23 (2015) : 3508-3515.
http://dx.doi.org/10.1016/j.febslet.2015.10.018
---------- MLA ----------
Yaneff, A., Vitali, V., Amodeo, G. "PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?" . FEBS Letters, vol. 589, no. 23, 2015, pp. 3508-3515.
http://dx.doi.org/10.1016/j.febslet.2015.10.018
---------- VANCOUVER ----------
Yaneff, A., Vitali, V., Amodeo, G. PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?. FEBS Lett. 2015;589(23):3508-3515.
http://dx.doi.org/10.1016/j.febslet.2015.10.018