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Abstract:

RSUME (for RWD-domain-containing sumoylation enhancer), RWDD3 gene, was identified from a pituitary tumor cell with increased tumorigenic and angiogenic potential, and has higher expression in cerebellum, pituitary, heart, kidney, liver, pancreas, adrenal gland and prostate. RSUME is induced by cellular stress like hypoxia and heat shock, and is increased in pituitary tumors, in gliomas and in VHL tumors. Seven splicing forms have been described. Two of them correspond to non-coding RNAs and the other five possess an RWD domain in the N-terminus and differ in their C-terminal end. RSUME enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favors sumoylation of specific targets. RSUME increases IκB levels and stabilizes HIF-1α during hypoxia, leading to inhibition of NF-κB and increased HIF-1 transcriptional activity. RSUME inhibits pVHL function, thus suppressing HIF-1 and 2α ubiquitination and degradation. Disruption of the RWD domain structure of RSUME indicated that this domain is critical for RSUME action. The findings point to an important role of RSUME in the regulation and stability of specific targets, which are key regulatory mediators in cancer and inflammation. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Role of RSUME in inflammation and cancer
Autor:Antico Arciuch, V.G.; Tedesco, L.; Fuertes, M.; Arzt, E.
Filiación:Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET, Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, C1425QD, Argentina
Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Hypoxia; RWD-domain-containing sumoylation enhancer; RWDD3; Sumoylation; VHL; carrier proteins and binding proteins; glucocorticoid; glucocorticoid receptor; hypoxia inducible factor 1; hypoxia inducible factor 1alpha; hypoxia inducible factor 2alpha; I kappa B; immunoglobulin enhancer binding protein; protein Ubc9; RWD domain containing sumoylation enhancer protein; SUMO protein; thioester; unclassified drug; vasculotropin A; von Hippel Lindau protein; RSUME protein, human; transcription factor; acetylation; amino terminal sequence; breast cancer; cancer growth; carboxy terminal sequence; carcinogenesis; conjugation; gene; gene expression; gene function; glioma; hemangioblastoma; hemangioblastoma of the central nervous system; homeostasis; human; hypophysis tumor; hypoxia; immune response; inflammation; kidney carcinoma; malignant neoplastic disease; pheochromocytoma of the adrenal gland; phosphorylation; prenylation; priority journal; protein degradation; protein domain; protein expression; protein function; protein processing; protein protein interaction; protein stability; protein structure; renal clear cell carcinoma; Review; RWDD3 gene; signal transduction; sumoylation; transcription initiation; transcription regulation; ubiquitination; VHL gene; animal; cell hypoxia; inflammation; metabolism; neoplasm; pathology; Animals; Cell Hypoxia; Humans; Inflammation; Neoplasms; Transcription Factors
Año:2015
Volumen:589
Número:22
Página de inicio:3330
Página de fin:3335
DOI: http://dx.doi.org/10.1016/j.febslet.2015.07.048
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:vasculotropin A, 489395-96-2; RSUME protein, human; Transcription Factors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3330_AnticoArciuch

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Citas:

---------- APA ----------
Antico Arciuch, V.G., Tedesco, L., Fuertes, M. & Arzt, E. (2015) . Role of RSUME in inflammation and cancer. FEBS Letters, 589(22), 3330-3335.
http://dx.doi.org/10.1016/j.febslet.2015.07.048
---------- CHICAGO ----------
Antico Arciuch, V.G., Tedesco, L., Fuertes, M., Arzt, E. "Role of RSUME in inflammation and cancer" . FEBS Letters 589, no. 22 (2015) : 3330-3335.
http://dx.doi.org/10.1016/j.febslet.2015.07.048
---------- MLA ----------
Antico Arciuch, V.G., Tedesco, L., Fuertes, M., Arzt, E. "Role of RSUME in inflammation and cancer" . FEBS Letters, vol. 589, no. 22, 2015, pp. 3330-3335.
http://dx.doi.org/10.1016/j.febslet.2015.07.048
---------- VANCOUVER ----------
Antico Arciuch, V.G., Tedesco, L., Fuertes, M., Arzt, E. Role of RSUME in inflammation and cancer. FEBS Lett. 2015;589(22):3330-3335.
http://dx.doi.org/10.1016/j.febslet.2015.07.048