Abstract:
Prostaglandin F2α (PGF2α) induces cyclin D1 expression and DNA synthesis in Swiss 3T3 cells. In order to assess which signaling mechanisms are implicated in these processes, we have used both a pharmacological approach and interfering mutants. We demonstrate that PGF2α induces extracellular-signal-regulated kinase (ERK1-2) and p38MAPK activation, and inhibition of any of these signaling pathways completely blocks PGF2α-stimulated DNA synthesis. We also show that ERK1-2, but not p38MAPK activation is required to induce cyclin D1 expression, strongly suggesting that the concerted action of cyclin D1 gene expression and other events are required to induce complete phosphorylation of retinoblastoma protein and S-phase entry in response to PGF2α. © 2006.
Registro:
Documento: |
Artículo
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Título: | Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α |
Autor: | Dekanty, A.; Giulianelli, S.; Coso, O.A.; Rudland, P.S.; Jimenez de Asua, L. |
Filiación: | Fundación Instituto Leloir, Av. Patricias Argentinas 435, 1405 Buenos Aires, Argentina Laboratorio de Fisiología y Biología Molecular, FCEyN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina School of Biological Sciences, University of Liverpool, Liverpool, L69 3BX, United Kingdom
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Palabras clave: | Cyclin D1; ERK1-2; MAPK; p38MAPK; Prostaglandin F2α; S-phase; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole; cyclin D1; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; prostaglandin F2 alpha; retinoblastoma protein; cyclin D1; mitogen activated protein kinase; prostaglandin F2 alpha; animal cell; article; cell cycle S phase; cell line; cell proliferation; controlled study; DNA synthesis; enzyme activation; enzyme induction; enzyme inhibition; gene expression; mouse; nonhuman; priority journal; protein expression; protein phosphorylation; signal transduction; animal; cell division; cell strain 3T3; DNA replication; drug effect; genetics; metabolism; polyacrylamide gel electrophoresis; Western blotting; Animalia; Animals; Blotting, Western; Cell Division; Cyclin D1; Dinoprost; DNA Replication; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Mice; Mitogen-Activated Protein Kinases; Swiss 3T3 Cells |
Año: | 2006
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Volumen: | 580
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Número: | 10
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Página de inicio: | 2512
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Página de fin: | 2516
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DOI: |
http://dx.doi.org/10.1016/j.febslet.2006.03.075 |
Título revista: | FEBS Letters
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Título revista abreviado: | FEBS Lett.
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ISSN: | 00145793
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CODEN: | FEBLA
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CAS: | 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene, 109511-58-2; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole, 152121-47-6; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; prostaglandin F2 alpha, 551-11-1; mitogen activated protein kinase, 142243-02-5; Cyclin D1, 136601-57-5; Dinoprost, 551-11-1; Mitogen-Activated Protein Kinases, 2.7.1.37
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PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00145793_v580_n10_p2512_Dekanty.pdf |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v580_n10_p2512_Dekanty |
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Citas:
---------- APA ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S. & Jimenez de Asua, L.
(2006)
. Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α. FEBS Letters, 580(10), 2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075---------- CHICAGO ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S., Jimenez de Asua, L.
"Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α"
. FEBS Letters 580, no. 10
(2006) : 2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075---------- MLA ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S., Jimenez de Asua, L.
"Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α"
. FEBS Letters, vol. 580, no. 10, 2006, pp. 2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075---------- VANCOUVER ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S., Jimenez de Asua, L. Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α. FEBS Lett. 2006;580(10):2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075