Artículo

Este artículo es de Acceso Abierto y puede ser descargado en su versión final desde nuestro repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Prostaglandin F2α (PGF2α) induces cyclin D1 expression and DNA synthesis in Swiss 3T3 cells. In order to assess which signaling mechanisms are implicated in these processes, we have used both a pharmacological approach and interfering mutants. We demonstrate that PGF2α induces extracellular-signal-regulated kinase (ERK1-2) and p38MAPK activation, and inhibition of any of these signaling pathways completely blocks PGF2α-stimulated DNA synthesis. We also show that ERK1-2, but not p38MAPK activation is required to induce cyclin D1 expression, strongly suggesting that the concerted action of cyclin D1 gene expression and other events are required to induce complete phosphorylation of retinoblastoma protein and S-phase entry in response to PGF2α. © 2006.

Registro:

Documento: Artículo
Título:Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α
Autor:Dekanty, A.; Giulianelli, S.; Coso, O.A.; Rudland, P.S.; Jimenez de Asua, L.
Filiación:Fundación Instituto Leloir, Av. Patricias Argentinas 435, 1405 Buenos Aires, Argentina
Laboratorio de Fisiología y Biología Molecular, FCEyN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
School of Biological Sciences, University of Liverpool, Liverpool, L69 3BX, United Kingdom
Palabras clave:Cyclin D1; ERK1-2; MAPK; p38MAPK; Prostaglandin F2α; S-phase; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole; cyclin D1; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; prostaglandin F2 alpha; retinoblastoma protein; cyclin D1; mitogen activated protein kinase; prostaglandin F2 alpha; animal cell; article; cell cycle S phase; cell line; cell proliferation; controlled study; DNA synthesis; enzyme activation; enzyme induction; enzyme inhibition; gene expression; mouse; nonhuman; priority journal; protein expression; protein phosphorylation; signal transduction; animal; cell division; cell strain 3T3; DNA replication; drug effect; genetics; metabolism; polyacrylamide gel electrophoresis; Western blotting; Animalia; Animals; Blotting, Western; Cell Division; Cyclin D1; Dinoprost; DNA Replication; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Mice; Mitogen-Activated Protein Kinases; Swiss 3T3 Cells
Año:2006
Volumen:580
Número:10
Página de inicio:2512
Página de fin:2516
DOI: http://dx.doi.org/10.1016/j.febslet.2006.03.075
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene, 109511-58-2; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole, 152121-47-6; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; prostaglandin F2 alpha, 551-11-1; mitogen activated protein kinase, 142243-02-5; Cyclin D1, 136601-57-5; Dinoprost, 551-11-1; Mitogen-Activated Protein Kinases, 2.7.1.37
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00145793_v580_n10_p2512_Dekanty.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v580_n10_p2512_Dekanty

Referencias:

  • Tapon, N., Hall, A., Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton (1997) Curr. Opin. Cell Biol., 9, pp. 86-92
  • Assoian, R.K., Zhu, X., Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression (1997) Curr. Opin Cell Biol., 9, pp. 93-98
  • Keely, P.J., Westwick, J.K., Whitehead, I.P., Der, C.J., Parise, L.V., Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K (1997) Nature, 390, pp. 632-636
  • Jimenez de Asua, L., Richmond, K.M., Otto, A.M., Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events (1981) Proc. Natl. Acad. Sci. USA, 78, pp. 1004-1008
  • Peter, M., Herskowitz, I., Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle (1994) Cell, 79, pp. 181-184
  • Hunter, T., Pines, J., Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age (1994) Cell, 79, pp. 573-582
  • Berridge, M.J., Cell signalling. A tale of two messengers (1993) Nature, 365, pp. 388-389
  • Matsushime, H., Roussel, M.F., Ashmun, R.A., Sherr, C.J., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle (1991) Cell, 65, pp. 701-713
  • Sherr, C.J., Roberts, J.M., Inhibitors of mammalian G1 cyclin-dependent kinases (1995) Genes Dev., 9, pp. 1149-1163
  • Rivard, N., L'Allemain, G., Bartek, J., Pouyssegur, J., Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts (1996) J. Biol. Chem., 271, pp. 18337-18341
  • Goin, M., Pignataro, O., Jimenez de Asua, L., Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2 alpha (PGF2 alpha) induced mitogenesis in Swiss 3T3 cells (1993) FEBS Lett., 316, pp. 68-72
  • Sales, K.J., Milne, S.A., Williams, A.R., Anderson, R.A., Jabbour, H.N., Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways (2004) J. Clin. Endocrinol. Metab., 89, pp. 986-993
  • Corps, A.N., Cheek, T.R., Moreton, R.B., Berridge, M.J., Brown, K.D., Single-cell analysis of the mitogen-induced calcium responses of normal and protein kinase C-depleted Swiss 3T3 cells (1989) Cell Regul., 1, pp. 75-86
  • Sauane, M., Correa, L., Rogers, F., Krasnapolski, M., Barraclough, R., Rudland, P.S., de Asua, L.J., Prostaglandin F2(alpha) induces cyclin D1 expression and DNA synthesis via early signaling mechanisms in Swiss mouse 3T3 cells (2000) Biochem. Biophys. Res. Commun., 270, pp. 11-16
  • Todaro, G.J., Green, H., Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines (1963) J. Cell Biol., 17, pp. 299-313
  • Levy, C.S., Sauane, M., Rudland, P.S., Jimenez de Asua, L., Leukaemia inhibitory factor induces mitogenesis in Swiss 3T3 cells and selective enhancement via a variety of signalling events (1997) Biochem. Biophys. Res. Commun., 236, pp. 814-818
  • Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J., Davis, R.J., Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine (1995) J. Biol. Chem., 270, pp. 7420-7426
  • Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J., Kato, J.Y., D-type cyclin-dependent kinase activity in mammalian cells (1994) Mol. Cell. Biol., 14, pp. 2066-2076
  • Favata, M.F., Identification of a novel inhibitor of mitogen-activated protein kinase kinase (1998) J. Biol. Chem., 273, pp. 18623-18632
  • Seufferlein, T., Withers, D.J., Rozengurt, E., Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin (1996) J. Biol. Chem., 271, pp. 21471-21477
  • Philips, A., Roux, P., Coulon, V., Bellanger, J.M., Vie, A., Vignais, M.L., Blanchard, J.M., Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts (2000) J. Biol. Chem., 275, pp. 5911-5917
  • Lavoie, J.N., L'Allemain, G., Brunet, A., Muller, R., Pouyssegur, J., Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway (1996) J. Biol. Chem., 271, pp. 20608-20616
  • Weber, J.D., Raben, D.M., Phillips, P.J., Baldassare, J.J., Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase (1997) Biochem. J., 326 (1), pp. 61-68

Citas:

---------- APA ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S. & Jimenez de Asua, L. (2006) . Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α. FEBS Letters, 580(10), 2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075
---------- CHICAGO ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S., Jimenez de Asua, L. "Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α" . FEBS Letters 580, no. 10 (2006) : 2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075
---------- MLA ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S., Jimenez de Asua, L. "Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α" . FEBS Letters, vol. 580, no. 10, 2006, pp. 2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075
---------- VANCOUVER ----------
Dekanty, A., Giulianelli, S., Coso, O.A., Rudland, P.S., Jimenez de Asua, L. Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2α. FEBS Lett. 2006;580(10):2512-2516.
http://dx.doi.org/10.1016/j.febslet.2006.03.075