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Pereira, C.A.; Alonso, G.D.; Ivaldi, S.; Silber, A.; Alves, M.J.M.; Bouvier, L.A.; Flawiá, M.M.; Torres, H.N. "Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication" (2002) FEBS Letters. 526(1-3):111-114
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Abstract:

L-Arginine plays an essential role in the energetic metabolism of Trypanosoma cruzi. In this work we propose a relationship between L-arginine uptake, arginine kinase activity and the parasite replication ability. In epimastigote cultures L-arginine uptake decreases continuously accompanying a cell replication rate reduction. The use of conditioned or fresh medium mimics uptake variations. Interestingly, in non-replicative trypomastigote cells, L-arginine uptake was undetectable. The association between L-arginine uptake and cell replication was demonstrated using the antimitotic agent hydroxyurea. Arginine kinase, the enzyme responsible for phosphoarginine and ATP synthesis, also shows a differential activity in epimastigote and trypomastigote parasite stages. © 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

Registro:

Documento: Artículo
Título:Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication
Autor:Pereira, C.A.; Alonso, G.D.; Ivaldi, S.; Silber, A.; Alves, M.J.M.; Bouvier, L.A.; Flawiá, M.M.; Torres, H.N.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Laboratório de Bioquímica de Parasitas, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
Palabras clave:Arginine kinase; Arginine transport; Arginine uptake; Phosphoarginine; Trypanosoma cruzi; adenosine triphosphate; antimitotic agent; arginine; arginine kinase; hydroxyurea; amino acid metabolism; article; cell division; enzyme activity; epimastigote; life cycle; nonhuman; polyacrylamide gel electrophoresis; priority journal; synthesis; Trypanosoma cruzi; trypomastigote; Western blotting; Animals; Arginine; Arginine Kinase; Biological Transport; Life Cycle Stages; Trypanosoma cruzi; Trypanosoma; Trypanosoma cruzi
Año:2002
Volumen:526
Número:1-3
Página de inicio:111
Página de fin:114
DOI: http://dx.doi.org/10.1016/S0014-5793(02)03157-5
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:Arginine Kinase, EC 2.7.3.3; Arginine, 74-79-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v526_n1-3_p111_Pereira

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Citas:

---------- APA ----------
Pereira, C.A., Alonso, G.D., Ivaldi, S., Silber, A., Alves, M.J.M., Bouvier, L.A., Flawiá, M.M.,..., Torres, H.N. (2002) . Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication. FEBS Letters, 526(1-3), 111-114.
http://dx.doi.org/10.1016/S0014-5793(02)03157-5
---------- CHICAGO ----------
Pereira, C.A., Alonso, G.D., Ivaldi, S., Silber, A., Alves, M.J.M., Bouvier, L.A., et al. "Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication" . FEBS Letters 526, no. 1-3 (2002) : 111-114.
http://dx.doi.org/10.1016/S0014-5793(02)03157-5
---------- MLA ----------
Pereira, C.A., Alonso, G.D., Ivaldi, S., Silber, A., Alves, M.J.M., Bouvier, L.A., et al. "Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication" . FEBS Letters, vol. 526, no. 1-3, 2002, pp. 111-114.
http://dx.doi.org/10.1016/S0014-5793(02)03157-5
---------- VANCOUVER ----------
Pereira, C.A., Alonso, G.D., Ivaldi, S., Silber, A., Alves, M.J.M., Bouvier, L.A., et al. Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication. FEBS Lett. 2002;526(1-3):111-114.
http://dx.doi.org/10.1016/S0014-5793(02)03157-5