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Abstract:

It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor (GR)/nuclear factor-κB (NF-κB) transrepression. Here we report a role for the nuclear receptor coactivator RAC3, in modulating NF-κB transactivation. We found that RAC3 functions as a coactivator by binding to the active form of NF-κB and that overexpression of RAC3 restores GR-dependent transcription neglecting GR/NF-κB transrepression. The competition between GR and NF-κB for binding to RAC3 may represent a general mechanism by which both transcription factors mutually antagonize their activity. (C) 2000 Federation of European Biochemical Societies.

Registro:

Documento: Artículo
Título:RAC-3 is a NF-κB coactivator
Autor:Werbajh, S.; Nojek, I.; Lanz, R.; Costas, M.A.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Cs. Biológicas, Pabellón II, C1428EHA Buenos Aires, Argentina
Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States
Palabras clave:Glucocorticoid receptor; Nuclear factor-κB; Nuclear receptor coactivator; Tumor necrosis factor; glucocorticoid receptor; immunoglobulin enhancer binding protein; transcription factor; transcription factor rac 3; tumor necrosis factor; unclassified drug; article; competitive inhibition; genetic transfection; human; human cell; modulation; molecular biology; priority journal; protein analysis; protein binding; protein expression; transactivation; transcription regulation; Binding, Competitive; Glucocorticoids; Hela Cells; Humans; Immunosorbent Techniques; NF-kappa B; Receptors, Glucocorticoid; Response Elements; Trans-Activators; Transcription Factor RelA; Transcription Factors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha
Año:2000
Volumen:485
Número:2-3
Página de inicio:195
Página de fin:199
DOI: http://dx.doi.org/10.1016/S0014-5793(00)02223-7
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:Glucocorticoids; NF-kappa B; Receptors, Glucocorticoid; steroid receptor coactivator AIB1; Trans-Activators; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00145793_v485_n2-3_p195_Werbajh.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v485_n2-3_p195_Werbajh

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Citas:

---------- APA ----------
Werbajh, S., Nojek, I., Lanz, R. & Costas, M.A. (2000) . RAC-3 is a NF-κB coactivator. FEBS Letters, 485(2-3), 195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7
---------- CHICAGO ----------
Werbajh, S., Nojek, I., Lanz, R., Costas, M.A. "RAC-3 is a NF-κB coactivator" . FEBS Letters 485, no. 2-3 (2000) : 195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7
---------- MLA ----------
Werbajh, S., Nojek, I., Lanz, R., Costas, M.A. "RAC-3 is a NF-κB coactivator" . FEBS Letters, vol. 485, no. 2-3, 2000, pp. 195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7
---------- VANCOUVER ----------
Werbajh, S., Nojek, I., Lanz, R., Costas, M.A. RAC-3 is a NF-κB coactivator. FEBS Lett. 2000;485(2-3):195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7