Artículo

Werbajh, S.; Nojek, I.; Lanz, R.; Costas, M.A. "RAC-3 is a NF-κB coactivator" (2000) FEBS Letters. 485(2-3):195-199
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Abstract:

It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor (GR)/nuclear factor-κB (NF-κB) transrepression. Here we report a role for the nuclear receptor coactivator RAC3, in modulating NF-κB transactivation. We found that RAC3 functions as a coactivator by binding to the active form of NF-κB and that overexpression of RAC3 restores GR-dependent transcription neglecting GR/NF-κB transrepression. The competition between GR and NF-κB for binding to RAC3 may represent a general mechanism by which both transcription factors mutually antagonize their activity. (C) 2000 Federation of European Biochemical Societies.

Registro:

Documento: Artículo
Título:RAC-3 is a NF-κB coactivator
Autor:Werbajh, S.; Nojek, I.; Lanz, R.; Costas, M.A.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Cs. Biológicas, Pabellón II, C1428EHA Buenos Aires, Argentina
Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States
Palabras clave:Glucocorticoid receptor; Nuclear factor-κB; Nuclear receptor coactivator; Tumor necrosis factor; glucocorticoid receptor; immunoglobulin enhancer binding protein; transcription factor; transcription factor rac 3; tumor necrosis factor; unclassified drug; article; competitive inhibition; genetic transfection; human; human cell; modulation; molecular biology; priority journal; protein analysis; protein binding; protein expression; transactivation; transcription regulation; Binding, Competitive; Glucocorticoids; Hela Cells; Humans; Immunosorbent Techniques; NF-kappa B; Receptors, Glucocorticoid; Response Elements; Trans-Activators; Transcription Factor RelA; Transcription Factors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha
Año:2000
Volumen:485
Número:2-3
Página de inicio:195
Página de fin:199
DOI: http://dx.doi.org/10.1016/S0014-5793(00)02223-7
Handle:http://hdl.handle.net/20.500.12110/paper_00145793_v485_n2-3_p195_Werbajh
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:Glucocorticoids; NF-kappa B; Receptors, Glucocorticoid; steroid receptor coactivator AIB1; Trans-Activators; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00145793_v485_n2-3_p195_Werbajh.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v485_n2-3_p195_Werbajh

Referencias:

  • Ghosh, S., May, M.J., Koop, E.B., (1998) Annu. Rev. Immunol., 16, pp. 225-260
  • Baeuerle, P.A., Baltimore, D., (1996) Cell, 87, pp. 13-20
  • Baldwin, A.S., (1996) Annu. Rev. Immunol., 14, pp. 649-681
  • Kaltschmidt, B., Kalschmidt, C., Hehner, S.P., Drogue, W., Schmitz, M.L., (1999) Oncogene, 18, pp. 3213-3225
  • Mukhopadhyay, T., Roth, J.A., Maxwell, S.A., (1996) Int. J. Oncol., 9, pp. 715-720
  • Liu, Z., Hsu, H., Goeddel, D.V., Karin, M., (1996) Cell, 87, pp. 565-576
  • Beg, A., Baltimore, D., (1996) Science, 274, pp. 782-784
  • Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., Verma, I.M., (1996) Science, 274, pp. 787-789
  • Chu, Z.-L., McKinsey, T., Liu, L., Gentry, J.J., Malim, M.H., Ballard, D.W., (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 10057-10062
  • Wang, C., Mayo, M.W., Korneluk, R.G., Goeddel, D.V., Baldwing A.S., Jr., (1998) Science, 281, pp. 1680-1683
  • Besedovsky, H., Del Rey, A., Sorkin, E., Dinarello, C.A., (1986) Science, 233, pp. 652-654
  • Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., Vale, W., (1987) Science, 238, pp. 22-24
  • Snyder, D.S., Unanue, E.R., (1982) J. Immunol., 129, pp. 1803-1805
  • Gillis, S., Crabtree, G.R., Smith, K., (1979) J. Immunol., 123, pp. 1624-1631
  • Cupps, T.R., Fauci, A.S., (1982) Immunol. Rev., 65, pp. 133-155
  • Hollenberg, S.M., Evans, R.M., (1988) Cell, 55, pp. 899-906
  • Scheiman, R.I., Gualberto, A., Jewell, C.M., Cdlowsky, J.A., Baldwin, J.R., (1995) Mol. Cell. Biol., 15, pp. 943-953
  • Scheinman, R.I., Cogswell, P.C., Lofquist, A.K., Baldwin A.S., Jr., (1995) Science, 270, pp. 283-286
  • Auphan, N., DiDonato, J.A., Rosette, C., Helmberg, A., Karin, M., (1995) Science, 270, pp. 286-290
  • Torchia, J., Glass, C.K., Rosenfeld, M.G., (1998) Curr. Opin. Cell Biol., 10, pp. 373-383
  • Xu, L., Glass, C.K., Rosenfeld, M.G., (1999) Curr. Opin. Genet. Devel., 9, pp. 140-147
  • DiCroce, L., Okret, S., Kersten, S., Gustafsson, M.P., Wahli, W., Beato, M., (1999) EMBO J., 18, pp. 6201-6210
  • McKenna, N., Lanz, R.B., O'Malley, B.W., (1999) Endocrine Rev., 20, pp. 321-344
  • Na, S.-Y., Lee, S.-K., Han, S.-J., Choi, H.-S., Im, S.-Y., Lee, J.W., (1998) J. Biol. Chem., 273, pp. 10831-10834
  • Zhong, H., Voll, R.E., Ghosh, S., (1998) Mol. Cell, 1, pp. 661-671
  • Sheppard, K.-A., Rose, D.W., Haque, Z.K., Kurokawa, R., McInerney, E., Westin, S., Thanos, D., Collins, T., (1999) Mol. Cell. Biol., 19, pp. 6367-6378
  • Sheppard, K.-A., Phelps, K.M., Williams, A.J., Thanos, D., Glass, C.K., Rosenfeld, M.G., Gerritsen, M.E., Collins, T., (1998) J. Biol. Chem., 273, pp. 29291-29294
  • McKay, L.I., Cidlowski, J., (2000) Mol. Endocrinol., 14, pp. 1222-1234
  • De Bosscher, K., Berghe, W.V., Vermeulen, L., Plaisance, S., Boone, E., Haegeman, G., (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 3919-3924
  • Anzick, S.L., Kononen, J., Walker, R.L., Azorsa, D.O., Tanner, M.M., Guan, X.Y., Sauler, G., Meltzer, P.S., (1997) Science, 277, pp. 965-968
  • Lanz, R.B., McKenna, N.J., Onate, S.A., Albrecht, U., Wong, J., Tsai, S.Y., Tsai, M.-J., O'Malley, B.W., (1999) Cell, 97, pp. 17-27
  • Voegel, J.J., Heine, M.J.S., Tini, M., Vivat, V., Chambon, P., Gronemeyer, H., (1998) EMBO J., 17, pp. 507-519
  • Costas, M., Trapp, T., Paez Pereda, M., Sauer, J., Rupprecht, R., Nahmod, V., Reul, J.M.H.M., Arzt, E., (1996) J. Clin. Invest., 98, pp. 1409-1416
  • Liden, J., Rafter, I., Truss, M., Gustafsson, J.-A., Okret, S., (2000) Biochem. Biophys. Res. Commun., 273, pp. 1008-1014

Citas:

---------- APA ----------
Werbajh, S., Nojek, I., Lanz, R. & Costas, M.A. (2000) . RAC-3 is a NF-κB coactivator. FEBS Letters, 485(2-3), 195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7
---------- CHICAGO ----------
Werbajh, S., Nojek, I., Lanz, R., Costas, M.A. "RAC-3 is a NF-κB coactivator" . FEBS Letters 485, no. 2-3 (2000) : 195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7
---------- MLA ----------
Werbajh, S., Nojek, I., Lanz, R., Costas, M.A. "RAC-3 is a NF-κB coactivator" . FEBS Letters, vol. 485, no. 2-3, 2000, pp. 195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7
---------- VANCOUVER ----------
Werbajh, S., Nojek, I., Lanz, R., Costas, M.A. RAC-3 is a NF-κB coactivator. FEBS Lett. 2000;485(2-3):195-199.
http://dx.doi.org/10.1016/S0014-5793(00)02223-7