Abstract:
Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events. © 1994.
Registro:
Documento: |
Artículo
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Título: | Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
Autor: | de Alzaga, M.G.; Goin, M.; Ortiz, M.; de Asua, L.J. |
Filiación: | Instituto de Investigaciones en Ingenieria Genética y Biología Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | DNA synthesis; Insulin; Protein kinase C; TGFβ1; glycerol 2 acetate 1 oleate; insulin; prostaglandin e1; prostaglandin f2 alpha; protein kinase c; transforming growth factor beta1; animal cell; article; controlled study; dna synthesis; mitogenesis; mouse; nonhuman; priority journal; signal transduction; 3T3 Cells; Alprostadil; Animal; Cell Division; Dinoprost; DNA; Insulin; Mice; Mitogens; Signal Transduction; Support, Non-U.S. Gov't; Transforming Growth Factor beta |
Año: | 1994
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Volumen: | 356
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Número: | 1
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Página de inicio: | 21
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Página de fin: | 24
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DOI: |
http://dx.doi.org/10.1016/0014-5793(94)01223-7 |
Título revista: | FEBS Letters
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Título revista abreviado: | FEBS Lett.
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ISSN: | 00145793
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CODEN: | FEBLA
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CAS: | glycerol 2 acetate 1 oleate, 84746-00-9; insulin, 9004-10-8; prostaglandin E1, 745-65-3; prostaglandin F2 alpha, 551-11-1; protein kinase C, 141436-78-4; Alprostadil, 745-65-3; Dinoprost, 551-11-1; DNA, 9007-49-2; Insulin, 11061-68-0; Mitogens; Transforming Growth Factor beta
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v356_n1_p21_deAlzaga |
Referencias:
- Jimenez, Richmond, Otto, Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events. (1981) Proceedings of the National Academy of Sciences, 78, pp. 1004-1008
- Rozengurt, (1986) Science, 234, pp. 161-166
- Pardee, (1989) Science, 246, pp. 603-608
- Massague, (1990) Annu. Rev. Cell Biol., 6, pp. 597-641
- Massague, Atisano, Wrana, (1994) Trends Cell Biol., 4, pp. 172-178
- Sporn, Roberts, Wakefield, Assoian, (1986) Science, 233, pp. 532-534
- Lin, Lodish, (1993) Trends Cell Biol., 3, pp. 14-19
- Brown, Holley, (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 3747-3747
- Goin, Pignataro, Jimenez, (1993) FEBS Lett., 316, pp. 68-72
- Zachary, Gil, Lehmann, Sinnett-Smith, Rozengurth, (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 4577-4581
- Jimenez, Goin, (1994) Eicosanoids and Other Bioactive Lipids in Cancer Inflammation and Radiation Injury, 3, pp. 525-532. , K.V. Hoon, L.J. Marnett, S. Nigam, Kluwer, Norwell, MA
- Todaro, Green, (1963) J. Cell Biol., 17, pp. 299-313
- Jimenez, O'Farrell, Bennet, Clingan, Rudland, (1977) Nature, 265, pp. 151-153
- Rozengurt, Rodriguez-Peña, Commbs, Sinnet-Smith, (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 5748-5752
- Jimenez, Estevez, Goin, (1992) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, 2, pp. 213-218. , S. Nigam, K.V. Honn, L.J. Marnett, T. Walden, Kluwer, Norwell, MA
- Tashjian, Voelkel, Lazzaro, Singer, Rorbets, Deryck, Mingler, Levine, (1985) Proc. Natl. Acad. Sci. USA, 82, pp. 4535-4538
- Diaz, Varga, Jimenez, J. Biol. Chem. 764 (1989) J. Biol. Chem. 764, pp. 11554-11557
- Corps, Cheek, Moreton, Berridge, Brown, (1989) Cell Reg., 1, pp. 75-86
- Roberts, Sporn, (1993) Growth Factors, 8, pp. 1-7
- Hamberg, Svenson, Sammuelson, (1974) Proc. Natl. Acad. Sci. USA, 71, pp. 3824-3828
- Karmali, Horrobin, Menezes, Patel, (1979) Pharmacol Res. Commun., 11, pp. 69-75
Citas:
---------- APA ----------
de Alzaga, M.G., Goin, M., Ortiz, M. & de Asua, L.J.
(1994)
. Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events. FEBS Letters, 356(1), 21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7---------- CHICAGO ----------
de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J.
"Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events"
. FEBS Letters 356, no. 1
(1994) : 21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7---------- MLA ----------
de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J.
"Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events"
. FEBS Letters, vol. 356, no. 1, 1994, pp. 21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7---------- VANCOUVER ----------
de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J. Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events. FEBS Lett. 1994;356(1):21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7