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Abstract:

The cAMP response element (CRE) and the CCAAT box of the fibronectin gene promoter are separated by only twenty base pairs. A specific factor that binds the CRE interacts cooperatively with the protein which binds to the adjacent CCAAT box, stimulating transcription [1992, J. Biol. Chem. 267, 12767-12774]. Here we show that the CRE factor is an heterodimer between a 43 kDa and the '73 kDa' CRE-binding proteins and we identify the latter as ATF-2 (also named CRE-BPI), a protein implicated in recruiting transcriptional activators to promoters, able to form heterodimers with Jun and for which a sequence-deduced MW of 55 kDa had been previously reported. © 1993.

Registro:

Documento: Artículo
Título:The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
Autor:Srebrow, A.; Muro, A.F.; Werbajh, S.; Sharp, P.A.; Kornblihtt, A.R.
Filiación:Instituto de Investigaciones en Ingeniería Genètica y Biología, Molecular (INGEBI) CONICET and Facultad de Ciencias, Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, 2 piso, 1428 Buenos Aires, Argentina
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Palabras clave:ATF-2; CAAT box; CRE; Fibronectin gene promoter; binding protein; endogenous compound; fibronectin; article; cyclic amp responsive element; gene expression; nonhuman; priority journal; promoter region; rat; transcription initiation; Animal; Base Sequence; Blood Proteins; DNA-Binding Protein, Cyclic AMP-Responsive; Fibronectins; Male; Molecular Sequence Data; Nuclear Proteins; Promoter Regions (Genetics); Rats; Rats, Sprague-Dawley; Support, Non-U.S. Gov't; Transcription Factors; Transcription, Genetic
Año:1993
Volumen:327
Número:1
Página de inicio:25
Página de fin:28
DOI: http://dx.doi.org/10.1016/0014-5793(93)81031-T
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:fibronectin, 86088-83-7; Blood Proteins; common cellular transcription factor ATF; DNA-Binding Protein, Cyclic AMP-Responsive; Fibronectins; Nuclear Proteins; Transcription Factors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v327_n1_p25_Srebrow

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Citas:

---------- APA ----------
Srebrow, A., Muro, A.F., Werbajh, S., Sharp, P.A. & Kornblihtt, A.R. (1993) . The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter. FEBS Letters, 327(1), 25-28.
http://dx.doi.org/10.1016/0014-5793(93)81031-T
---------- CHICAGO ----------
Srebrow, A., Muro, A.F., Werbajh, S., Sharp, P.A., Kornblihtt, A.R. "The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter" . FEBS Letters 327, no. 1 (1993) : 25-28.
http://dx.doi.org/10.1016/0014-5793(93)81031-T
---------- MLA ----------
Srebrow, A., Muro, A.F., Werbajh, S., Sharp, P.A., Kornblihtt, A.R. "The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter" . FEBS Letters, vol. 327, no. 1, 1993, pp. 25-28.
http://dx.doi.org/10.1016/0014-5793(93)81031-T
---------- VANCOUVER ----------
Srebrow, A., Muro, A.F., Werbajh, S., Sharp, P.A., Kornblihtt, A.R. The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter. FEBS Lett. 1993;327(1):25-28.
http://dx.doi.org/10.1016/0014-5793(93)81031-T