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Abstract:

R59022, a diacylglycerol kinase inhibitor, enhances the prostaglandin F2α (PGF2α)-induced diacylglycerol (DAG) synthesis in Swiss 3T3 cells. It also potentiates the PGF2α-mediated protein kinase C (PKC)-dependent 80 kDa protein (80K) phosphorylation and initiation of DNA replication. R 59022 enhances the PGF2α mitogenic response by increasing the rate of entry into the S phase. Insulin does not cause 80K phosphorylation, and does not enhance its induction but it potentiates the PGF2α mitogenic response. These results suggest that mitogenically triggered fluctuations in DAG content and PKC activity play a pivotal role in controlling the PGF2α-induced DNA synthesis while insulin acts via a different mechanism. © 1993.

Registro:

Documento: Artículo
Título:Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2α (PGF2α) induced mitogenesis in Swiss 3T3 cells
Autor:Goin, M.; Pignataro, O.; de Asua, L.J.
Filiación:Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina
Instituto de Biologia y Medicina Experimental (IBYME), Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Diacylglycerol kinase; DNA synthesis; Prostaglandin F2α; Protein kinase C; R 59022; 6 [2 [4 [(4 fluorophenyl)phenylmethylene] 1 piperidyl]ethyl] 7 methyl 5h thiazolo[3,2 a]pyrimidin 5 one; diacylglycerol; insulin; prostaglandin f2 alpha; protein kinase c; animal cell; article; cell cycle; mitogenesis; mouse; nonhuman; priority journal; 3T3 Cells; Animal; Cell Cycle; Cell Division; Diacylglycerol Kinase; Diglycerides; Dinoprost; DNA Replication; Insulin; Mice; Phosphorylation; Phosphotransferases; Protein Kinase C; Pyrimidinones; Support, Non-U.S. Gov't; Thiazoles
Año:1993
Volumen:316
Número:1
Página de inicio:68
Página de fin:72
DOI: http://dx.doi.org/10.1016/0014-5793(93)81738-L
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:6 [2 [4 [(4 fluorophenyl)phenylmethylene] 1 piperidyl]ethyl] 7 methyl 5h thiazolo[3,2 a]pyrimidin 5 one, 93076-89-2; insulin, 9004-10-8; prostaglandin F2 alpha, 551-11-1; protein kinase C, 141436-78-4; Diacylglycerol Kinase, EC 2.7.1.107; Diglycerides; Dinoprost, 551-11-1; Insulin, 11061-68-0; Phosphotransferases, EC 2.7; Protein Kinase C, EC 2.7.1.37; Pyrimidinones; R 59022, 93076-89-2; Thiazoles
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v316_n1_p68_Goin

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Citas:

---------- APA ----------
Goin, M., Pignataro, O. & de Asua, L.J. (1993) . Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2α (PGF2α) induced mitogenesis in Swiss 3T3 cells. FEBS Letters, 316(1), 68-72.
http://dx.doi.org/10.1016/0014-5793(93)81738-L
---------- CHICAGO ----------
Goin, M., Pignataro, O., de Asua, L.J. "Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2α (PGF2α) induced mitogenesis in Swiss 3T3 cells" . FEBS Letters 316, no. 1 (1993) : 68-72.
http://dx.doi.org/10.1016/0014-5793(93)81738-L
---------- MLA ----------
Goin, M., Pignataro, O., de Asua, L.J. "Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2α (PGF2α) induced mitogenesis in Swiss 3T3 cells" . FEBS Letters, vol. 316, no. 1, 1993, pp. 68-72.
http://dx.doi.org/10.1016/0014-5793(93)81738-L
---------- VANCOUVER ----------
Goin, M., Pignataro, O., de Asua, L.J. Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2α (PGF2α) induced mitogenesis in Swiss 3T3 cells. FEBS Lett. 1993;316(1):68-72.
http://dx.doi.org/10.1016/0014-5793(93)81738-L