Abstract:
Ornithine decarboxylase (ODC) of Crithidia fasciculata extracts shows maximal activity during exponential growth of the parasite and decreases markedly in the stationary phase. The inhibition of protein synthesis by cycloheximide evoked a rapid loss of enzyme activity with a half-life of about 30 min. Upon removal of DFMO from Crithidia cultures treated with the drug for 24 h, the ODC activity increased at the same rate as total protein synthesis. The addition of putrescine at high concentrations to parasites cultivated in a synthetic medium showed that Crithidia CDC levels were not reduced by polyamines. © 1992.
Registro:
Documento: |
Artículo
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Título: | Ornithine decarboxylase from Crithidia fasciculata is metabolically unstable and resistant to polyamine down-regulation |
Autor: | Ceriani, C.; González, N.S.; Algranati, I.D. |
Filiación: | Instituto de Investigaciones Bioquímicas 'Fundación Campomar', Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, A. Machado 151, 1405 Buenos Aires, Argentina
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Palabras clave: | Crithidia fasciculata; Enzyme turnover; Ornithine decarboxylase; Polyamine-dependent regulation; ornithine decarboxylase; polyamine; article; crithidia fasciculata; down regulation; nonhuman; priority journal; protein metabolism; Animal; Catalysis; Crithidia fasciculata; Down-Regulation; Ornithine Decarboxylase; Polyamines; Putrescine; Support, Non-U.S. Gov't |
Año: | 1992
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Volumen: | 301
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Número: | 3
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Página de inicio: | 261
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Página de fin: | 264
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DOI: |
http://dx.doi.org/10.1016/0014-5793(92)80253-D |
Título revista: | FEBS Letters
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Título revista abreviado: | FEBS Lett.
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ISSN: | 00145793
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CODEN: | FEBLA
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CAS: | ornithine decarboxylase, 9024-60-6; Ornithine Decarboxylase, EC 4.1.1.17; Polyamines; Putrescine, 110-60-1
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PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00145793_v301_n3_p261_Ceriani.pdf |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v301_n3_p261_Ceriani |
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Citas:
---------- APA ----------
Ceriani, C., González, N.S. & Algranati, I.D.
(1992)
. Ornithine decarboxylase from Crithidia fasciculata is metabolically unstable and resistant to polyamine down-regulation. FEBS Letters, 301(3), 261-264.
http://dx.doi.org/10.1016/0014-5793(92)80253-D---------- CHICAGO ----------
Ceriani, C., González, N.S., Algranati, I.D.
"Ornithine decarboxylase from Crithidia fasciculata is metabolically unstable and resistant to polyamine down-regulation"
. FEBS Letters 301, no. 3
(1992) : 261-264.
http://dx.doi.org/10.1016/0014-5793(92)80253-D---------- MLA ----------
Ceriani, C., González, N.S., Algranati, I.D.
"Ornithine decarboxylase from Crithidia fasciculata is metabolically unstable and resistant to polyamine down-regulation"
. FEBS Letters, vol. 301, no. 3, 1992, pp. 261-264.
http://dx.doi.org/10.1016/0014-5793(92)80253-D---------- VANCOUVER ----------
Ceriani, C., González, N.S., Algranati, I.D. Ornithine decarboxylase from Crithidia fasciculata is metabolically unstable and resistant to polyamine down-regulation. FEBS Lett. 1992;301(3):261-264.
http://dx.doi.org/10.1016/0014-5793(92)80253-D