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Abstract:

Prostaglandin F2α (PGF2α) selectively decreases the binding of 125I-labelled epidermal growth factor ([125I]EGF) to intact Swiss 3T3 cells. Scatchard analysis reveals that PGF2α decreases the number of high-affinity EGF binding sites without changing the total number of receptors. Prostaglandins E1 (PGE1), E2 (PGE2 or F2β (PGF2β) do not alter the EGF binding to these cells and do not enhance the PGF2α effect. R-59022 and R-59949, two diacylglycerol kinase inhibitors, enhance the inhibitory effect of PGF2α, whereas down-modulation of protein kinase C (PKC) abolishes the effect. These results indicate that PGF2α, decreases EGF binding in Swiss 3T3 cells via PKC activation. © 1992.

Registro:

Documento: Artículo
Título:Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation
Autor:de Asua, L.J.; Goin, M.
Filiación:Department of Biochemistry, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT, United Kingdom
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Diacylglycerol; DNA synthesis; Epidermal growth factor receptor; Prostaglandin F2α; Protein kinase C; Swiss 3T3 cells; 3 [2 [4 (4,4' difluorobenzhydrylidene)piperidino]ethyl] 2,3 dihydro 2 thioxo 4(1h) quinazolinone; 6 [2 [4 [(4 fluorophenyl)phenylmethylene] 1 piperidyl]ethyl] 7 methyl 5h thiazolo[3,2 a]pyrimidin 5 one; enzyme inhibitor; epidermal growth factor; epidermal growth factor receptor; prostaglandin derivative; prostaglandin f2 alpha; protein kinase c; diacylglycerol kinase; epidermal growth factor; epidermal growth factor receptor; phosphotransferase; prostaglandin E; prostaglandin F2 alpha; protein kinase C; animal cell; article; binding affinity; enzyme activation; mouse; nonhuman; priority journal; receptor binding; animal; cell strain 3T3; dose response; drug effect; enzyme activation; metabolism; sensitivity and specificity; 3T3 Cells; Animal; Diacylglycerol Kinase; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphotransferases; Prostaglandins E; Protein Kinase C; Receptor, Epidermal Growth Factor; Sensitivity and Specificity; Support, Non-U.S. Gov't
Año:1992
Volumen:299
Número:3
Página de inicio:235
Página de fin:238
DOI: http://dx.doi.org/10.1016/0014-5793(92)80122-W
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:3 [2 [4 (4,4' difluorobenzhydrylidene)piperidino]ethyl] 2,3 dihydro 2 thioxo 4(1h) quinazolinone, 120166-69-0; 6 [2 [4 [(4 fluorophenyl)phenylmethylene] 1 piperidyl]ethyl] 7 methyl 5h thiazolo[3,2 a]pyrimidin 5 one, 93076-89-2; epidermal growth factor, 62229-50-9; prostaglandin F2 alpha, 551-11-1; protein kinase C, 141436-78-4; Diacylglycerol Kinase, EC 2.7.1.107; Dinoprost, 551-11-1; Epidermal Growth Factor, 62229-50-9; Phosphotransferases, EC 2.7; Prostaglandins E; Protein Kinase C, EC 2.7.1.37; Receptor, Epidermal Growth Factor, EC 2.7.1.112
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v299_n3_p235_deAsua

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Citas:

---------- APA ----------
de Asua, L.J. & Goin, M. (1992) . Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation. FEBS Letters, 299(3), 235-238.
http://dx.doi.org/10.1016/0014-5793(92)80122-W
---------- CHICAGO ----------
de Asua, L.J., Goin, M. "Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation" . FEBS Letters 299, no. 3 (1992) : 235-238.
http://dx.doi.org/10.1016/0014-5793(92)80122-W
---------- MLA ----------
de Asua, L.J., Goin, M. "Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation" . FEBS Letters, vol. 299, no. 3, 1992, pp. 235-238.
http://dx.doi.org/10.1016/0014-5793(92)80122-W
---------- VANCOUVER ----------
de Asua, L.J., Goin, M. Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation. FEBS Lett. 1992;299(3):235-238.
http://dx.doi.org/10.1016/0014-5793(92)80122-W