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Abstract:

Prostaglandin F2α (PGF2α), a mitogen for resting Swiss 3T3 cells, rapidly stimulates phosphorylation of an 80 kDa protein (80 K). 1-Oleoyl-2-acetylglycerol (OAG) and 12-O-tetradecanoyl phorbol-13-acetate (TPA) both protein kinase C (PKC) activators, also elicit 80 K phosphorylation. In contrast PGE1, PGE2 or PGF2β, which are non-mitogenic in these cells, had tittle or no action on this event. However PGE1 and PGE2 potentiate the PGF2α proliferative effect but do not enhance its action on 80 K phosphorylation. These results suggest that PGF2α mitogenic induction involves PKC signalling pathway activation while its enhancement by PGE1 or PGE2 occurs through a different mechanism(s). © 1992.

Registro:

Documento: Artículo
Título:Stimulation of protein kinase C (PKC) activity in resting Swiss 3T3 cells by prostaglandin F2α
Autor:Goin, M.; de Asua, L.J.
Filiación:Instituto de Investigaciones en Ingenieria Genética y Biologia Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:80 K phosphorylation; DNA synthesis; Prostaglandin F2α; Protein kinase C; Swiss 3T3 cell; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; protein kinase c; animal cell; article; enzyme activation; mouse; nonhuman; priority journal; 3T3 Cells; Alprostadil; Animal; Cell Division; Diglycerides; Dinoprost; Dinoprostone; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Mice; Phosphorylation; Protein Kinase C; Support, Non-U.S. Gov't; Tetradecanoylphorbol Acetate
Año:1992
Volumen:297
Número:1-2
Página de inicio:175
Página de fin:178
DOI: http://dx.doi.org/10.1016/0014-5793(92)80354-J
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; protein kinase C, 141436-78-4; 1-oleoyl-2-acetylglycerol, 86390-77-4; Alprostadil, 745-65-3; Diglycerides; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; DNA, 9007-49-2; Protein Kinase C, EC 2.7.1.37; Tetradecanoylphorbol Acetate, 16561-29-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v297_n1-2_p175_Goin

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Citas:

---------- APA ----------
Goin, M. & de Asua, L.J. (1992) . Stimulation of protein kinase C (PKC) activity in resting Swiss 3T3 cells by prostaglandin F2α. FEBS Letters, 297(1-2), 175-178.
http://dx.doi.org/10.1016/0014-5793(92)80354-J
---------- CHICAGO ----------
Goin, M., de Asua, L.J. "Stimulation of protein kinase C (PKC) activity in resting Swiss 3T3 cells by prostaglandin F2α" . FEBS Letters 297, no. 1-2 (1992) : 175-178.
http://dx.doi.org/10.1016/0014-5793(92)80354-J
---------- MLA ----------
Goin, M., de Asua, L.J. "Stimulation of protein kinase C (PKC) activity in resting Swiss 3T3 cells by prostaglandin F2α" . FEBS Letters, vol. 297, no. 1-2, 1992, pp. 175-178.
http://dx.doi.org/10.1016/0014-5793(92)80354-J
---------- VANCOUVER ----------
Goin, M., de Asua, L.J. Stimulation of protein kinase C (PKC) activity in resting Swiss 3T3 cells by prostaglandin F2α. FEBS Lett. 1992;297(1-2):175-178.
http://dx.doi.org/10.1016/0014-5793(92)80354-J