Abstract:
Tunicamycin, an inhibitor of the asparagine-linked protein N-glycosylation, blocks the initiation of DNA synthesis in Swiss 3T3 cells stimulated by prostaglandin F2α alone or with insulin. This effect is exerted only when tunicamycin is added from 0 to 8 h after stimulation and it decreases the rate of entry into S phase. Blocking of labeled sugar incorporation to proteins occurs regardless of the time of PGF2α stimulation. In contrast tunicamicin does not inhibit protein synthesis. These results suggest that N-glycoprotein synthesis early during the prereplicative phase is an important event controlling the mitogenic action of PGF2α. © 1991.
Registro:
Documento: |
Artículo
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Título: | Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells |
Autor: | Estevez, A.G.; Calamante, G.; Goin, M.; de Asua, L.J. |
Filiación: | Instituto de Investigaciones en Ingenieria Genética y Biologia Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | DNA synthesis; Lag phase; Prostaglandin F2α; Swiss 3T3 cell; Tunicamycin; insulin; prostaglandin f2 alpha; tunicamycin; animal cell; article; cell growth; dna synthesis; mouse; nonhuman; priority journal; 3T3 Cells; Animal; Cell Division; Dinoprost; DNA; Glucosamine; Glycoproteins; In Vitro; Insulin; Mannose; Mice; Support, Non-U.S. Gov't; Time Factors; Tunicamycin; Animalia |
Año: | 1991
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Volumen: | 290
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Número: | 1-2
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Página de inicio: | 239
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Página de fin: | 242
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DOI: |
http://dx.doi.org/10.1016/0014-5793(91)81269-E |
Título revista: | FEBS Letters
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Título revista abreviado: | FEBS Lett.
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ISSN: | 00145793
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CODEN: | FEBLA
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CAS: | Dinoprost, 551-11-1; DNA, 9007-49-2; Glucosamine, 3416-24-8; Glycoproteins; Insulin, 11061-68-0; Mannose, 31103-86-3; Tunicamycin, 11089-65-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v290_n1-2_p239_Estevez |
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Citas:
---------- APA ----------
Estevez, A.G., Calamante, G., Goin, M. & de Asua, L.J.
(1991)
. Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells. FEBS Letters, 290(1-2), 239-242.
http://dx.doi.org/10.1016/0014-5793(91)81269-E---------- CHICAGO ----------
Estevez, A.G., Calamante, G., Goin, M., de Asua, L.J.
"Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells"
. FEBS Letters 290, no. 1-2
(1991) : 239-242.
http://dx.doi.org/10.1016/0014-5793(91)81269-E---------- MLA ----------
Estevez, A.G., Calamante, G., Goin, M., de Asua, L.J.
"Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells"
. FEBS Letters, vol. 290, no. 1-2, 1991, pp. 239-242.
http://dx.doi.org/10.1016/0014-5793(91)81269-E---------- VANCOUVER ----------
Estevez, A.G., Calamante, G., Goin, M., de Asua, L.J. Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells. FEBS Lett. 1991;290(1-2):239-242.
http://dx.doi.org/10.1016/0014-5793(91)81269-E