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Abstract:

Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was measured. Anti-class I, but not anti-class II products specifically increased phosphoinositide turnover. This increment was partially blocked by muscarinic cholinergic and α-adrenergic blockers and even more so by the phospholipase C inhibitor NCDC. Alloantibodies specifically directed against class I antigens could then exert stimulation of phospholipase C-mediated phosphoinositide hydrolysis through the interaction with muscarinic cholinergic and/or α-adrenergic receptors. The induction of intracellular second messengers by class I antigens and hormone-receptor interactions is discussed. © 1989.

Registro:

Documento: Artículo
Título:Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
Autor:Cremaschi, G.A.; Sterin-Borda, L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales, CONICET, Serrano 665, 1414 Buenos Aires, Argentina
Palabras clave:Adrenergic receptor, α-; Alloantibody; Histocompatibility antigen; Muscarinic cholinergic receptor; Phosphoinositide turnover; Phospholipase C; adrenergic receptor; alloantibody; muscarinic receptor; phosphatidylinositide; phospholipase c; radioisotope; animal cell; histocompatibility; mouse; nonhuman; priority journal; Animal; Heart Atrium; Histocompatibility Antigens Class I; Hydrolysis; Immunoglobulin G; In Vitro; Isoantibodies; Mice; Mice, Inbred C3H; Myocardium; Phosphatidylinositols; Receptors, Adrenergic, alpha; Receptors, Cholinergic; Support, Non-U.S. Gov't
Año:1989
Volumen:249
Número:2
Página de inicio:302
Página de fin:306
DOI: http://dx.doi.org/10.1016/0014-5793(89)80646-5
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:phospholipase C, 9001-86-9; Histocompatibility Antigens Class I; Immunoglobulin G; Isoantibodies; Phosphatidylinositols; Receptors, Adrenergic, alpha; Receptors, Cholinergic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v249_n2_p302_Cremaschi

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Citas:

---------- APA ----------
Cremaschi, G.A. & Sterin-Borda, L. (1989) . Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue. FEBS Letters, 249(2), 302-306.
http://dx.doi.org/10.1016/0014-5793(89)80646-5
---------- CHICAGO ----------
Cremaschi, G.A., Sterin-Borda, L. "Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue" . FEBS Letters 249, no. 2 (1989) : 302-306.
http://dx.doi.org/10.1016/0014-5793(89)80646-5
---------- MLA ----------
Cremaschi, G.A., Sterin-Borda, L. "Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue" . FEBS Letters, vol. 249, no. 2, 1989, pp. 302-306.
http://dx.doi.org/10.1016/0014-5793(89)80646-5
---------- VANCOUVER ----------
Cremaschi, G.A., Sterin-Borda, L. Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue. FEBS Lett. 1989;249(2):302-306.
http://dx.doi.org/10.1016/0014-5793(89)80646-5