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Abstract:

Epidermal growth factor (EGF) induces fibronectin (FN) and FN mRNA in rat liver epithelial cells, under conditions where the factor also induces the cells to migrate. Newly synthesized protein is secreted into the medium and deposited as substratum-bound extracellular matrix. The levels of mRNA and the amount of protein synthesized are not influenced by cyclic AMP or dexamethasone, factors that have been found to modulate FN expression in other cells. However, the cells are sensitive to the factors, suggesting a cell-specific regulation. The EGF-induced RNA contains the sequences EIIIA and EIIIB characteristic of cellular fibronectin. © 1988.

Registro:

Documento: Artículo
Título:Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
Autor:Seebacher, T.; Manske, M.; Kornblihtt, A.R.; Bade, E.G.
Filiación:Fakultät für Biologie, Universität Konstanz, Postfach 5560, D-7750 Konstanz, Germany
Instituto de Ingeniería Genética y Biología Molecular, Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:(Rat liver epithelial cell); Cell migration; Cellular fibronectin; Epidermal growth factor; Extracellular matrix; Gene expression; mRNA splicing variant; cyclic amp; dexamethasone; epidermal growth factor; fibronectin; animal cell; cell culture; cell migration; epithelium cell; extracellular matrix; gene expression; liver epithelium; nonhuman; priority journal; rat; rna splicing; Animal; Cells, Cultured; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; Epithelium; Fibronectins; Insulin; Liver; Rats; Reference Values; RNA Splicing; RNA, Messenger
Año:1988
Volumen:239
Número:1
Página de inicio:113
Página de fin:116
DOI: http://dx.doi.org/10.1016/0014-5793(88)80556-8
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:cyclic AMP, 60-92-4; dexamethasone, 50-02-2; epidermal growth factor, 62229-50-9; fibronectin, 86088-83-7; Cyclic AMP, 60-92-4; Dexamethasone, 50-02-2; Epidermal Growth Factor, 62229-50-9; Fibronectins; Insulin, 11061-68-0; RNA, Messenger
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v239_n1_p113_Seebacher

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Citas:

---------- APA ----------
Seebacher, T., Manske, M., Kornblihtt, A.R. & Bade, E.G. (1988) . Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells. FEBS Letters, 239(1), 113-116.
http://dx.doi.org/10.1016/0014-5793(88)80556-8
---------- CHICAGO ----------
Seebacher, T., Manske, M., Kornblihtt, A.R., Bade, E.G. "Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells" . FEBS Letters 239, no. 1 (1988) : 113-116.
http://dx.doi.org/10.1016/0014-5793(88)80556-8
---------- MLA ----------
Seebacher, T., Manske, M., Kornblihtt, A.R., Bade, E.G. "Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells" . FEBS Letters, vol. 239, no. 1, 1988, pp. 113-116.
http://dx.doi.org/10.1016/0014-5793(88)80556-8
---------- VANCOUVER ----------
Seebacher, T., Manske, M., Kornblihtt, A.R., Bade, E.G. Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells. FEBS Lett. 1988;239(1):113-116.
http://dx.doi.org/10.1016/0014-5793(88)80556-8