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Abstract:

Fibronectins (FNs) are extracellular glycoproteins consisting of dimers or multimers of similar but not identical subunits. The subunit differences result from variations in internal primary sequence due to alternative splicing in at least 2 regions of the pre-mRNA. The complete amino acid sequence of mature human cellular FN has been reported recently from cDNA cloning and sequencing. The same approach has now enabled us to deduce, for the first time, that FN has a 26 amino acid signal peptide and that it undergoes proteolytic processing at its N-terminus to eliminate a 5 amino acid pro-sequence (Ser-Lys-Ser-Lys-Arg). The signal sequence matches the consensus format, while this pro-sequence is a distinctive, very hydrophilic and basic peptide. © 1986.

Registro:

Documento: Artículo
Título:Human fibronectin is synthesized as a pre-propolypeptide
Autor:Gutman, A.; Yamada, K.M.; Kornblihtt, A.
Filiación:>Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI-CONICET), Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, United States
Palabras clave:(Human); cDNA; Fibronectin; Pro-peptide; Signal peptide; complementary dna; fibronectin; protein precursor; radioisotope; signal peptide; amino acid sequence; cell culture; genetic engineering; heredity; human; human cell; in vitro study; priority journal; protein processing; protein structure; protein synthesis; Amino Acid Sequence; DNA; Fibronectins; Human; Peptides; Protein Precursors; RNA, Messenger
Año:1986
Volumen:207
Número:1
Página de inicio:145
Página de fin:148
DOI: http://dx.doi.org/10.1016/0014-5793(86)80029-1
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:fibronectin, 86088-83-7; DNA, 9007-49-2; Fibronectins; Peptides; Protein Precursors; RNA, Messenger
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v207_n1_p145_Gutman

Referencias:

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Citas:

---------- APA ----------
Gutman, A., Yamada, K.M. & Kornblihtt, A. (1986) . Human fibronectin is synthesized as a pre-propolypeptide. FEBS Letters, 207(1), 145-148.
http://dx.doi.org/10.1016/0014-5793(86)80029-1
---------- CHICAGO ----------
Gutman, A., Yamada, K.M., Kornblihtt, A. "Human fibronectin is synthesized as a pre-propolypeptide" . FEBS Letters 207, no. 1 (1986) : 145-148.
http://dx.doi.org/10.1016/0014-5793(86)80029-1
---------- MLA ----------
Gutman, A., Yamada, K.M., Kornblihtt, A. "Human fibronectin is synthesized as a pre-propolypeptide" . FEBS Letters, vol. 207, no. 1, 1986, pp. 145-148.
http://dx.doi.org/10.1016/0014-5793(86)80029-1
---------- VANCOUVER ----------
Gutman, A., Yamada, K.M., Kornblihtt, A. Human fibronectin is synthesized as a pre-propolypeptide. FEBS Lett. 1986;207(1):145-148.
http://dx.doi.org/10.1016/0014-5793(86)80029-1