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Abstract:

Trypanosoma cruzi, a protozoan responsible for the American trypanosomiasis (Chagas disease), multiplies and differentiates in the gut of triatomine insect vectors. The effects of hemoglobin and synthetic peptides carrying αD-globin fragments on both the growth and the transformation of T. cruzi epimastigotes (noninfective) into metacyclic trypomastigotes (infective forms) were studied. This differentiation in the insect′s gut is expressed when hemoglobin and synthetic peptides corresponding to residues 30-49 and 35-73 of the αD-globin were added to the plasma diet. However, synthetic peptide 41-73 does not induce differentiation of epimastigotes even in the presence of the two former synthetic peptides. Thus, these data delineate an unusual molecular mechanism which modulates the dynamics of transformation of epimastigotes into metacyclic trypomastigotes in the triatomine vector′s gut. © 1995 Academic press, Inc.

Registro:

Documento: Artículo
Título:Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences
Autor:Garcia, E.S.; Gonzalez, M.S.; De Azambuja, P.; Baralle, F.E.; Fraidenraich, D.; Torres, H.N.; Flawia, M.M.
Filiación:Department of Biochemistry and Molecular Biology, Oswalde Cruz Foundation, Avenida Brasil 4365, 2/045-900, Bio de Janeiro, Brazil
Department of General Biology, Universidade Federal Fluminense, Niterói, 2400, Brazil
International Centre for Genetic Engineering and Biotechnology, Patriciano 99, 340/2 Trieste, Italy
Instituto de Investigaciones en Ingenieri Genética y Biologia Molecular, Obligado 2490, 1428, Buenos Aires, Argentina
Palabras clave:hemoglobin; peptide; synthetic peptide; amino acid sequence; article; chagas disease; epimastigote; nonhuman; priority journal; trypanosoma cruzi; trypomastigote; Amino Acid Sequence; Animals; Globins; Hemoglobins; Insect Vectors; Larva; Molecular Sequence Data; Rhodnius; Trypanosoma cruzi
Año:1995
Volumen:81
Número:3
Página de inicio:255
Página de fin:261
DOI: http://dx.doi.org/10.1006/expr.1995.1116
Título revista:Experimental Parasitology
Título revista abreviado:Exp. Parasitol.
ISSN:00144894
CAS:Globins, 9004-22-2; Hemoglobins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144894_v81_n3_p255_Garcia

Referencias:

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  • Brener, Z., Biology of Trypanosoma cruzi (1973) Annual Review of Microbiology, 27, pp. 347-383
  • Chagas, C., Nova tripanomiase humana. Estudos sobre a morfologia e o ciclo evolutivo do Schizotrypanum cruzi, n. Gen. N. Sp, Agente etiológico de nova entidade mórbida do homem (1909) Memorias Do Instituto Oswaldo Cruz, 1, pp. 159-218
  • Coso, O., Díaz A Nel, A., Martinetto, H., Muschi Etti, J., Kazanietz, M., Fraidenraich, D., Torres, H.N., Flawia, M.M., Characterization of a G,-protein from Trypanosoma cruzi epimastigote membranes (1992) Biochemical Journal, 287, pp. 443-446
  • Eisenschlos, C., Paladini, A., Molina Y Vedia, L., Torres, H.N., Flawia, M.M., Evidence for the existence of a Ns-type regulatory protein in Trypanosoma cruzi membranes (1986) Biochemical Journal, 237, pp. 913-917
  • Fraidenraich, D., Peña, C., Isola, E., Lammel, E., Coso, O., Díaz Añel, A., Pongor, S., Flawia, M.M., Stimulation of Trypanosoma cruzi adenylyl cyclase by an aD-globin fragment from Triatoma hindgut: Effect of differentiation of epimastigote to try pom asti g ote forms (1993) Proceedings of the National Academy of the Sciences, USA, 90, pp. 10140-10144
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  • Garcia, E.S., Gonzalez, M.S., Azambuja, P., Rembold, H., Chagas' disease and its insect vector. Effect of azadirachtin A on the interaction of a triatomine host {Rhodnius prolixus) and its parasite (Trypanosoma cruzi) (1989) Zeitzchrift für Naturforschung, 44c, pp. 317-322
  • Garcia, E.S., Gonzalez, M.S., Rembold, H., Chagas' disease and its insect vector. Curing effect of azadirachtin A in the triatomine host, Rhodnius prolixus, from its parasite, Trypanosoma cruzi (1989) Host Regulated Developmental Mechanisms in Vector Arthropods, pp. 263-269. , D. Borovsky and A. Spielman, Eds.), Univ. of Florida, Vero Beach
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  • Rangel-Aldo, R., Allende, O., Triana, F., Piras, R., Enrique, D., Pi Ras, M., Possible role of cAMP in the differentiation of Trypanosoma cruzi (1987) Molecular and Biochemical Parasitology, 22, pp. 39-43
  • Snhdecor, G.W., (1964) Statistical Methods Applied to Experiments in Agriculture and Biology, , Iowa State Univ. Press, Ames, I A
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  • Zeledon, R., Life cycle of Trypanosoma cruzi in the insect vector (1987) Chagas Disease Vectors: Anatomical and Physiological Aspects, Vol. 11, pp. 59-75. , R. R. Brenner and A. M. Stoka, Eds.), CRC Press, Boca Raton, FL

Citas:

---------- APA ----------
Garcia, E.S., Gonzalez, M.S., De Azambuja, P., Baralle, F.E., Fraidenraich, D., Torres, H.N. & Flawia, M.M. (1995) . Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences. Experimental Parasitology, 81(3), 255-261.
http://dx.doi.org/10.1006/expr.1995.1116
---------- CHICAGO ----------
Garcia, E.S., Gonzalez, M.S., De Azambuja, P., Baralle, F.E., Fraidenraich, D., Torres, H.N., et al. "Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences" . Experimental Parasitology 81, no. 3 (1995) : 255-261.
http://dx.doi.org/10.1006/expr.1995.1116
---------- MLA ----------
Garcia, E.S., Gonzalez, M.S., De Azambuja, P., Baralle, F.E., Fraidenraich, D., Torres, H.N., et al. "Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences" . Experimental Parasitology, vol. 81, no. 3, 1995, pp. 255-261.
http://dx.doi.org/10.1006/expr.1995.1116
---------- VANCOUVER ----------
Garcia, E.S., Gonzalez, M.S., De Azambuja, P., Baralle, F.E., Fraidenraich, D., Torres, H.N., et al. Induction of trypanosoma cruzi metacyclogenesis in the gut of the hematophagous insect vector, rhodnius prolixus, by hemoglobin and peptides carrying αD-globin sequences. Exp. Parasitol. 1995;81(3):255-261.
http://dx.doi.org/10.1006/expr.1995.1116