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Abstract:

In isolated skeletal, heart, and smooth muscle cells from BALB/c and C3H/HeJ mice infected with different strains of Trypanosoma cruzi the presence of class II MHC molecules was investigated by immunocytochemical techniques. We employed single muscle fibers instead of conventional cryostat sections to obtain a more accurate antigen localization. Approximately half of the skeletal muscle cells isolated from the reclus femoris expressed Ia antigens on their surface, irrespective of the mouse or parasite strain combination. Ia expression was apparent only at 30 days postinfection and thereafter. The heart muscle cells expressed class II molecules only at 1 and 3 months postinfection. In no case did the smooth muscle cells from infected mice express Ia antigens. Studies of the same molecules in the noninfected animals gave constantly negative results. We conclude that in the course of the chronic infection of mice with T. cruzi, ectopic expression of class II MHC molecules occurs at the surface of skeletal and heart muscle cells, providing a possible mechanism for explaining the anti-striped muscle autoreactivity present in Chagas' disease. © 1991.

Registro:

Documento: Artículo
Título:Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice
Autor:Meckert, P.C.; Hontebeyrie-Joskowicz, M.; Chambo, J.; Levin, M.; Laguens, R.P.
Filiación:Cátedra de Patología II, Facultad de Ciencias Médicas, Universidad de La Plata, Calle 60 y 120, 1900 La Plata, Argentina
Unité d' Immunoparasitologie, Institut Pasteur, 25, Rue du Dr. Roux, 75724 Paris Cedex 15, France
Laboratorio de Biología Molecular de la Enfermedad de Chagas, I.N.G.E.B.I., Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Autoimmunity; Chagas' disease; Heart muscle cells; Ia antigens; Skeletal muscle cells; Trypanosoma cruzi; antigen; animal experiment; antigen expression; article; female; major histocompatibility complex; mouse; nonhuman; trypanosoma cruzi; Animal; Cells, Cultured; Chagas Disease; Female; Heart; Histocompatibility Antigens Class II; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Muscle, Smooth; Muscles; Support, Non-U.S. Gov't; Trypanosoma cruzi; Animalia; Trypanosoma; Trypanosoma cruzi
Año:1991
Volumen:72
Número:1
Página de inicio:8
Página de fin:14
DOI: http://dx.doi.org/10.1016/0014-4894(91)90115-D
Título revista:Experimental Parasitology
Título revista abreviado:Exp. Parasitol.
ISSN:00144894
CODEN:EXPAA
CAS:Histocompatibility Antigens Class II
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144894_v72_n1_p8_Meckert

Referencias:

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  • Ben Younes-Chennoufi, Said, Eisen, Durand, Hontebeyrie-Joskowicz, Cellular immunity to Trypanosoma cruzi is mediated by helper T cells (CD4+) (1988) Transactions of the Royal Society of Tropical Medicine and Hygiene, 82, pp. 84-89
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Citas:

---------- APA ----------
Meckert, P.C., Hontebeyrie-Joskowicz, M., Chambo, J., Levin, M. & Laguens, R.P. (1991) . Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice. Experimental Parasitology, 72(1), 8-14.
http://dx.doi.org/10.1016/0014-4894(91)90115-D
---------- CHICAGO ----------
Meckert, P.C., Hontebeyrie-Joskowicz, M., Chambo, J., Levin, M., Laguens, R.P. "Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice" . Experimental Parasitology 72, no. 1 (1991) : 8-14.
http://dx.doi.org/10.1016/0014-4894(91)90115-D
---------- MLA ----------
Meckert, P.C., Hontebeyrie-Joskowicz, M., Chambo, J., Levin, M., Laguens, R.P. "Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice" . Experimental Parasitology, vol. 72, no. 1, 1991, pp. 8-14.
http://dx.doi.org/10.1016/0014-4894(91)90115-D
---------- VANCOUVER ----------
Meckert, P.C., Hontebeyrie-Joskowicz, M., Chambo, J., Levin, M., Laguens, R.P. Trypanosoma cruzi: Aberrant expression of class II major histocompatibility complex molecules in skeletal and heart muscle cells of chronically infected mice. Exp. Parasitol. 1991;72(1):8-14.
http://dx.doi.org/10.1016/0014-4894(91)90115-D