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Abstract:

IIB-MEL-J is a highly heterogeneous newly established human melanoma cell line. The addition of 3 mM, l-tyrosine to the culture medium produced (1) a great decrease in the cell growth rate, (2) a loss of the anchorage-independent growth capacity, and (3) a change in the morphology of the cells to a fibroblastoid aspect. Coincident with these changes, an increase in subpopulations I and II and a decrease in subpopulations III and IV took place. In view of this evidence we consider that the cells have differentiated. The melanin production was not increased by the l-tyrosine treatment, suggesting that differentiation and melanin expression are not strictly correlated. © 1990.

Registro:

Documento: Artículo
Título:Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
Autor:Guerra, L.; Bover, L.; Mordoh, J.
Filiación:Instituto de Investigaciones Bioquimicas Luis F. Leloir Fundacion Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Patricias Argentinas 435, 1405 Buenos Aires, Argentina
Palabras clave:melanin; tyrosine; article; cell culture; cell differentiation; human; human cell; melanoma cell; priority journal; Cell Adhesion; Cell Separation; Cell Transformation, Neoplastic; Centrifugation, Density Gradient; Human; Lung Neoplasms; Melanins; Melanoma; Middle Age; Support, Non-U.S. Gov't; Tumor Cells, Cultured; Tyrosine
Año:1990
Volumen:188
Número:1
Página de inicio:61
Página de fin:65
DOI: http://dx.doi.org/10.1016/0014-4827(90)90278-I
Título revista:Experimental Cell Research
Título revista abreviado:Exp. Cell Res.
ISSN:00144827
CODEN:ECREA
CAS:Melanins; Tyrosine, 55520-40-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144827_v188_n1_p61_Guerra

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Citas:

---------- APA ----------
Guerra, L., Bover, L. & Mordoh, J. (1990) . Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J. Experimental Cell Research, 188(1), 61-65.
http://dx.doi.org/10.1016/0014-4827(90)90278-I
---------- CHICAGO ----------
Guerra, L., Bover, L., Mordoh, J. "Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J" . Experimental Cell Research 188, no. 1 (1990) : 61-65.
http://dx.doi.org/10.1016/0014-4827(90)90278-I
---------- MLA ----------
Guerra, L., Bover, L., Mordoh, J. "Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J" . Experimental Cell Research, vol. 188, no. 1, 1990, pp. 61-65.
http://dx.doi.org/10.1016/0014-4827(90)90278-I
---------- VANCOUVER ----------
Guerra, L., Bover, L., Mordoh, J. Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J. Exp. Cell Res. 1990;188(1):61-65.
http://dx.doi.org/10.1016/0014-4827(90)90278-I