Garcia-Rill, E.; Kezunovic, N.; D'Onofrio, S.; Luster, B.; Hyde, J.; Bisagno, V.; Urbano, F.J. "Gamma band activity in the RAS-intracellular mechanisms" (2014) Experimental Brain Research. 232(5):1509-1522
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Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane properties behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus, intralaminar parafascicular nucleus, and pontine SubCoeruleus nucleus dorsalis all fire in the gamma band range when maximally activated, but no higher. The mechanisms involve high-threshold, voltage-dependent P/Q-type calcium channels, or sodium-dependent subthreshold oscillations. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness and provide the essential stream of information for the formulation of many of our actions. We address three necessary next steps resulting from these discoveries: an intracellular mechanism responsible for maintaining gamma band activity based on persistent G-protein activation, separate intracellular pathways that differentiate between gamma band activity during waking versus during REM sleep, and an intracellular mechanism responsible for the dysregulation in gamma band activity in schizophrenia. These findings open several promising research avenues that have not been thoroughly explored. What are the effects of sleep or REM sleep deprivation on these RAS mechanisms? Are these mechanisms involved in memory processing during waking and/or during REM sleep? Does gamma band processing differ during waking versus REM sleep after sleep or REM sleep deprivation? © 2013 Springer-Verlag.


Documento: Artículo
Título:Gamma band activity in the RAS-intracellular mechanisms
Autor:Garcia-Rill, E.; Kezunovic, N.; D'Onofrio, S.; Luster, B.; Hyde, J.; Bisagno, V.; Urbano, F.J.
Filiación:Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Slot 847, 4301 West Markham St., Little Rock, AR 72205, United States
IFIBYNE, CONICET-UBA, Buenos Aires, Argentina
ININFA, CONICET-UBA, Buenos Aires, Argentina
Palabras clave:Arousal; Calcium/calmodulin-dependent protein kinase II; Cyclic adenosine monophosphate; G-proteins; Neuronal calcium sensor; Schizophrenia; calcium; calcium channel P type; calcium channel Q type; guanine nucleotide binding protein; calcium channel N type; voltage-dependent calcium channel (P-Q type); ascending reticular activating system; awareness; brain function; calcium cell level; consciousness; gamma band activity; high frequency oscillation; human; memory consolidation; pedunculopontine tegmental nucleus; priority journal; REM sleep; REM sleep deprivation; review; schizophrenia; thalamus parafascicular nucleus; wakefulness; animal; biological model; brain cortex; cytology; gamma rhythm; mesencephalon reticular formation; nerve cell; physiology; Animals; Calcium Channels, N-Type; Cerebral Cortex; Gamma Rhythm; Humans; Midbrain Reticular Formation; Models, Biological; Neurons; Sleep, REM
Página de inicio:1509
Página de fin:1522
Título revista:Experimental Brain Research
Título revista abreviado:Exp. Brain Res.
CAS:calcium, 7440-70-2, 14092-94-5; Calcium Channels, N-Type; voltage-dependent calcium channel (P-Q type)


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---------- APA ----------
Garcia-Rill, E., Kezunovic, N., D'Onofrio, S., Luster, B., Hyde, J., Bisagno, V. & Urbano, F.J. (2014) . Gamma band activity in the RAS-intracellular mechanisms. Experimental Brain Research, 232(5), 1509-1522.
---------- CHICAGO ----------
Garcia-Rill, E., Kezunovic, N., D'Onofrio, S., Luster, B., Hyde, J., Bisagno, V., et al. "Gamma band activity in the RAS-intracellular mechanisms" . Experimental Brain Research 232, no. 5 (2014) : 1509-1522.
---------- MLA ----------
Garcia-Rill, E., Kezunovic, N., D'Onofrio, S., Luster, B., Hyde, J., Bisagno, V., et al. "Gamma band activity in the RAS-intracellular mechanisms" . Experimental Brain Research, vol. 232, no. 5, 2014, pp. 1509-1522.
---------- VANCOUVER ----------
Garcia-Rill, E., Kezunovic, N., D'Onofrio, S., Luster, B., Hyde, J., Bisagno, V., et al. Gamma band activity in the RAS-intracellular mechanisms. Exp. Brain Res. 2014;232(5):1509-1522.