Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azederach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures. © 1986 Birkhäuser Verlag Basel.
Documento: | Artículo |
Título: | An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice |
Autor: | Andrei, G.M.; Lampuri, J.S.; Coto, C.E.; de Torres, R.A. |
Filiación: | Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, piso 4, Ciudad Universitaria, Buenos Aires, 1428, Argentina Departamento de Microbiología e Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, 1113, Argentina |
Palabras clave: | Antiviral activity; arenavirus; Melia azedarach L; Tacaribe virus; viral encephalitis; antivirus agent; central nervous system; experimental infection; higher plant; mouse; nonhuman; priority journal; tacaribe arenavirus; therapy; virus encephalitis; Animal; Animals, Newborn; Antiviral Agents; Arenaviruses, New World; Encephalitis; Female; Hemorrhagic Fever, American; Lactation; Mice; Plant Extracts; Pregnancy; Support, Non-U.S. Gov't; Virus Replication |
Año: | 1986 |
Volumen: | 42 |
Número: | 7 |
Página de inicio: | 843 |
Página de fin: | 845 |
DOI: | http://dx.doi.org/10.1007/BF01941548 |
Título revista: | Experientia |
Título revista abreviado: | Experientia |
ISSN: | 00144754 |
CODEN: | EXPEA |
CAS: | Antiviral Agents; Plant Extracts |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v42_n7_p843_Andrei |