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Abstract:

Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 108 M-1, only 10 times lower than the association constant for estradiol. © 1986 Birkhäuser Verlag Basel.

Registro:

Documento: Artículo
Título:Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland
Autor:Lüthy, I.A.; Calandra, R.S.
Filiación:Instituto de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:adrenal; bromocriptine; Estrogen receptors; sulpiride; bromocriptine; corticotropin; estradiol; radioisotope; sulpiride; adrenal gland; animal cell; drug administration; drug efficacy; drug interaction; drug receptor binding; endocrine system; estradiol h 3; estrogen binding; etiology; methodology; nonhuman; pharmacokinetics; priority journal; rat; Adrenal Glands; Animal; Binding, Competitive; Bromocriptine; Cytosol; Estradiol; Male; Rats; Rats, Inbred Strains; Receptors, Estradiol; Receptors, Estrogen; Sulpiride
Año:1986
Volumen:42
Número:2
Página de inicio:136
Página de fin:138
DOI: http://dx.doi.org/10.1007/BF01952433
Título revista:Experientia
Título revista abreviado:Experientia
ISSN:00144754
CODEN:EXPEA
CAS:bromocriptine, 25614-03-3; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; estradiol, 50-28-2; sulpiride, 15676-16-1; Bromocriptine, 25614-03-3; Estradiol, 50-28-2; Receptors, Estradiol; Receptors, Estrogen; Sulpiride, 15676-16-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v42_n2_p136_Luthy

Referencias:

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  • Kitay, J.I., Coyne, M.D., Newsom, W., Nelson, R., (1965) Endocrinology, 77, p. 902
  • van Beurden-Lamers, W.M.O., Brinkmann, A.O., Mulder, E., van der Molen, H.J., (1974) Biochem. J., 140, p. 495
  • Calandra, R.S., Naess, O., Purvis, K., Attramadal, A., Djøseland, O., Hansson, V., (1978) J. Ster. Biochem., 9, p. 957
  • Calandra, R.S., Finocchiaro, L.M.E., Lüthy, I.A., Cheb-Terrab, R., (1979) Acta physiol. latinoam., 29, p. 333
  • Müller, R., Wotiz, H.H., (1978) J. biol. Chem., 253, p. 740
  • Cutler, G.B., Barnes, K.M., Sauer, M.A., Loriaux, D.E., (1978) Endocrinology, 102, p. 252
  • Lüthy, I.A., Chiauzzi, V.A., Charreau, E.H., Calandra, R.S., (1984) Acta physiol. pharmac. latinoam., 34, p. 15
  • Calandra, R.S., Lüthy, I.A., Finocchiaro, L., Cheb-Terrab, R., (1980) J. Ster. Biochem., 13, p. 1331
  • Best-Belpomme, M., Dessen, P., (1973) Biochimie, 55, p. 11
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  • Weinstein, D., Schenker, J.G., Gloger, I., Slonin, J.H., De Groot, N., Hochberg, A.A., Folman, R., (1981) FEBS Lett., 126, p. 29
  • MacLeod, R.M., Robyn, C.J., (1977) Endocrinology, 72, p. 273
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  • Bartke, A., Lackritz, R.M., (1981) Fert. Steril., 35, p. 473
  • Suescun, M. O., Gonzalez, S. I., and Calandra, R. S., manuscript in preparation; Thorner, M.O., Schran, H.F., Evans, W.S., Rogol, A.D., Morris, J.L., MacLeod, R.J., (1980) J. clin. Endocr. Metab., 50, p. 1026
  • Di Carlo, F., Reboani, C., Conti, G., Portaleone, P., Viano, I., Genazzani, E., (1980) Pharmacological Modulation of Steroid Action, p. 61. , E., Genazzani, F., Di Carlo, W. I. P., Mainwaring, Raven Press, New York
  • Levy, J., Aflalo, L., and Glick, S. M., Second Innsbruck Winter Conference on Biochemistry in Clinical Medicine (1981), Abstr. 17

Citas:

---------- APA ----------
Lüthy, I.A. & Calandra, R.S. (1986) . Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland. Experientia, 42(2), 136-138.
http://dx.doi.org/10.1007/BF01952433
---------- CHICAGO ----------
Lüthy, I.A., Calandra, R.S. "Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland" . Experientia 42, no. 2 (1986) : 136-138.
http://dx.doi.org/10.1007/BF01952433
---------- MLA ----------
Lüthy, I.A., Calandra, R.S. "Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland" . Experientia, vol. 42, no. 2, 1986, pp. 136-138.
http://dx.doi.org/10.1007/BF01952433
---------- VANCOUVER ----------
Lüthy, I.A., Calandra, R.S. Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland. Experientia. 1986;42(2):136-138.
http://dx.doi.org/10.1007/BF01952433