The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as well as by inhibitiors of cyclo-oxygenase and prostacyclinsynthetase. © 1983 Birkhäuser Verlag.
Documento: | Artículo |
Título: | Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors? |
Autor: | Borda, E.; Sterin-Borda, L.; Gimeno, M.F.; Lazzari, M.; Gimeno, A.L. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas, de la República Argentina (CONICET), Serrano 665/69, Buenos Aires, 1414, Argentina Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Serrano 665/69, Buenos Aires, 1414, Argentina |
Palabras clave: | 4 aminophenol; acetylsalicylic acid; alpha adrenergic receptor; indometacin; methoxamine; phentolamine; propranolol; prostacyclin; prostacyclin synthase; tranylcypromine; animal cell; ant; aorta; drug efficacy; great blood vessel; nonhuman; rat; Animals; Aorta, Abdominal; Epoprostenol; Indomethacin; Male; Methoxamine; Muscle Contraction; Platelet Aggregation; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Vasodilator Agents; Animalia; Formicidae |
Año: | 1983 |
Volumen: | 39 |
Número: | 8 |
Página de inicio: | 894 |
Página de fin: | 896 |
DOI: | http://dx.doi.org/10.1007/BF01990425 |
Título revista: | Experientia |
Título revista abreviado: | Experientia |
ISSN: | 00144754 |
CODEN: | EXPEA |
CAS: | 4 aminophenol, 123-30-8; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; methoxamine, 390-28-3, 61-16-5; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostacyclin, 35121-78-9, 61849-14-7; prostacyclin synthase, 65802-86-0; tranylcypromine, 13492-01-8, 155-09-9, 54-97-7; Epoprostenol, 35121-78-9; Indomethacin, 53-86-1; Methoxamine, 390-28-3; Prostaglandins; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Vasodilator Agents |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v39_n8_p894_Borda |