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Abstract:

A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions. © 1983 Birkhäuser Verlag.

Registro:

Documento: Artículo
Título:Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes
Autor:Castillo, M.B.; Gonzalez, M.D.; Burton, G.; Lantos, C.P.; Roldán, A.
Filiación:Laboratorio de Esteroides, Instituto de Biologia y Medicina Experimental, 1428 Buenos Aires, Argentina
Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellón 2-Ciudad Universitaria, Buenos Aires, 1428, Argentina
Laboratorio de Esteroides, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina
Palabras clave:11beta hydroxypregna 1,4 diene 3,20 dione; 11beta hydroxyprogesterone; 17 deoxyprednisolone; c 21 steroid; corticosterone; cortisone; glucocorticoid; hydrocortisone; prednisolone; radioisotope; unclassified drug; uridine h 3; article; cytolysis; dose response; drug efficacy; drug response; in vitro study; nonhuman; rat; RNA synthesis; thymocyte; thymus; Animals; Female; Glucocorticoids; Hydroxyprogesterones; Male; Rats; Rats, Inbred Strains; RNA; T-Lymphocytes; Thymus Gland; Uridine
Año:1983
Volumen:39
Número:6
Página de inicio:617
Página de fin:618
DOI: http://dx.doi.org/10.1007/BF01971126
Título revista:Experientia
Título revista abreviado:Experientia
ISSN:00144754
CODEN:EXPEA
CAS:11beta hydroxyprogesterone, 600-57-7; 17 deoxyprednisolone, 13479-38-4; corticosterone, 50-22-6; cortisone, 53-06-5; hydrocortisone, 50-23-7; prednisolone, 50-24-8; 11-hydroxyprogesterone, 312-90-3; Glucocorticoids; Hydroxyprogesterones; RNA, 63231-63-0; Uridine, 58-96-8; pregna-1,4-diene-11-ol-3,20-dione, 4224-37-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v39_n6_p617_Castillo

Referencias:

  • Baxter, J.D., Rousseau, G.G., (1979) Glucocorticoid hormone action, p. 1. , J.D., Baxter, G.G., Rousseau, Springer, Heidelberg
  • Roldán, A., Burton, G., Castillo, M.B., Damasco, M.C., Lantos, C.P., (1981) J. Steroid Biochem., 15, p. 467
  • Giddings, S.J., Young, D., (1974) J. Steroid Biochem., 5, p. 587
  • Thomas, N., Bell, P.A., (1981) Molec. cell. Endocr., 22, p. 71
  • Morita, Y., Munck, A., (1964) Biochim. biophys. Acta, 93, p. 150
  • Gelehrter, T.D., McDonald, R.A., (1981) Endocrinology, 109, p. 476
  • Dougherty, T.F., Berliner, G.L., Schneebeli, G.L., Berliner, D.L., (1964) Ann. N.Y. Acad. Sci., 113, p. 825
  • Nelson, D.H., (1980) Endocr. Rev., 1, p. 180

Citas:

---------- APA ----------
Castillo, M.B., Gonzalez, M.D., Burton, G., Lantos, C.P. & Roldán, A. (1983) . Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes. Experientia, 39(6), 617-618.
http://dx.doi.org/10.1007/BF01971126
---------- CHICAGO ----------
Castillo, M.B., Gonzalez, M.D., Burton, G., Lantos, C.P., Roldán, A. "Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes" . Experientia 39, no. 6 (1983) : 617-618.
http://dx.doi.org/10.1007/BF01971126
---------- MLA ----------
Castillo, M.B., Gonzalez, M.D., Burton, G., Lantos, C.P., Roldán, A. "Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes" . Experientia, vol. 39, no. 6, 1983, pp. 617-618.
http://dx.doi.org/10.1007/BF01971126
---------- VANCOUVER ----------
Castillo, M.B., Gonzalez, M.D., Burton, G., Lantos, C.P., Roldán, A. Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes. Experientia. 1983;39(6):617-618.
http://dx.doi.org/10.1007/BF01971126