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Abstract:

The administration of 15(R)-15-methyl prostaglandin E2 (15(R)-15-M-PGE2) in vivo significantly diminished the uptake of59Fe into blood, spleen, liver, femur and dried intestine of rats, whereas acetylsalicylic acid (ASA) increased the counts significantly. This effect of ASA was counteracted by 15(R)-15-M-PGE2. It is suggested that prostaglandins (PGs) might play an important role in inhibiting iron absorption at the intestinal level. © 1982 Birkhäuser Verlag.

Registro:

Documento: Artículo
Título:Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat
Autor:Gutnisky, A.; Glikman, P.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), de la República Argentina, Serrano 665/69, Buenos Aires, 1414, Argentina
Palabras clave:15 methylprostaglandin e2 methyl ester; acetylsalicylic acid; iron; iron 59; radioisotope; animal experiment; digestive system; drug absorption; drug interaction; drug potentiation; intestine absorption; oral drug administration; pharmacokinetics; rat; Animal; Arbaprostil; Aspirin; Femur; Intestinal Absorption; Iron; Iron Radioisotopes; Liver; Male; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Spleen; Support, Non-U.S. Gov't
Año:1982
Volumen:38
Número:1
Página de inicio:116
Página de fin:117
DOI: http://dx.doi.org/10.1007/BF01944561
Título revista:Experientia
Título revista abreviado:Experientia
ISSN:00144754
CODEN:EXPEA
CAS:15 methylprostaglandin E2 methyl ester, 36210-00-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; iron 59, 14596-12-4; iron, 14093-02-8, 53858-86-9, 7439-89-6; Arbaprostil, 55028-70-1; Aspirin, 50-78-2; Iron Radioisotopes; Iron, 7439-89-6; Prostaglandins E, Synthetic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v38_n1_p116_Gutnisky

Referencias:

  • Powell, E.L.W., Halliday, L.W., Barret, M.L., (1979) Aust. N.Z.J. Med., 9, p. 578
  • Becker, G., Korpilla-Schäfer, S., Osterloh, K., Forth, W., (1979) Blut, 38, p. 127
  • Wheby, M.S., Jones, L.G., Crosby, W.H., (1964) J. clin. Invest., 43, p. 1433
  • Gitlin, D., Cruchaud, A., (1962) J. clin. Invest., 41, p. 344
  • Hahw, P.F., Carothers, E.L., Darly, W.J., Marin, M., Sheppard, C.W., Beam, R.O., Densen, P.M., McClellan, C.S., (1951) Am. J. Obstet. Gynec., 61, p. 477
  • Heinrich, H.C., (1970) Intestinal Iron Absorption, Methods of Measurement, Dose Relationship, Diagnostic and Therapeutic Application, Iron Deficiency, p. 213. , Academic Press, London/New York
  • Gutnisky, A., Speziale, E., Gimeno, M.F., Gimeno, A.L., (1979) Experientia, 35, p. 623
  • Gutnisky, A., Speziale, E., Gimeno, M.F., Gimeno, A.L., (1980) Acta physiol. latinoam., 30, p. 217
  • Glikman, P., Gutnisky, A., Gimeno, M.F., Gimeno, A.L., (1981) Experientia, 37, p. 589
  • Flower, R.J., (1974) Pharmac. Rev., 26, p. 33

Citas:

---------- APA ----------
Gutnisky, A., Glikman, P., Gimeno, M.F. & Gimeno, A.L. (1982) . Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat. Experientia, 38(1), 116-117.
http://dx.doi.org/10.1007/BF01944561
---------- CHICAGO ----------
Gutnisky, A., Glikman, P., Gimeno, M.F., Gimeno, A.L. "Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat" . Experientia 38, no. 1 (1982) : 116-117.
http://dx.doi.org/10.1007/BF01944561
---------- MLA ----------
Gutnisky, A., Glikman, P., Gimeno, M.F., Gimeno, A.L. "Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat" . Experientia, vol. 38, no. 1, 1982, pp. 116-117.
http://dx.doi.org/10.1007/BF01944561
---------- VANCOUVER ----------
Gutnisky, A., Glikman, P., Gimeno, M.F., Gimeno, A.L. Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat. Experientia. 1982;38(1):116-117.
http://dx.doi.org/10.1007/BF01944561