Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium. © 1981 Birkhäuser Verlag.
Documento: | Artículo |
Título: | A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures |
Autor: | Cardinali, D.P.; Vacas, M.I.; Ritta, M.N. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Obligado 2490, Buenos Aires, 1428, Argentina |
Palabras clave: | 5 methoxytryptophol; estradiol; melatonin; puromycin; radioisotope; serotonin; animal experiment; drug metabolism; endocrine system; in vitro study; organ culture; pineal body; rat; Animal; Dose-Response Relationship, Drug; Estradiol; Organ Culture; Pineal Gland; Puromycin; Rats; Serotonin; Support, Non-U.S. Gov't |
Año: | 1981 |
Volumen: | 37 |
Número: | 2 |
Página de inicio: | 203 |
Página de fin: | 204 |
DOI: | http://dx.doi.org/10.1007/BF01963234 |
Título revista: | Experientia |
Título revista abreviado: | Experientia |
ISSN: | 00144754 |
CODEN: | EXPEA |
CAS: | 5 methoxytryptophol, 712-09-4; estradiol, 50-28-2; melatonin, 73-31-4; puromycin, 53-79-2, 58-58-2; serotonin, 50-67-9; Estradiol, 50-28-2; Puromycin, 53-79-2; Serotonin, 50-67-9 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v37_n2_p203_Cardinali |