Arsenite but not oxamate produce in vitro a distinct depression of estrogen-dominated uterine motility, both in the absence of substrate as well as in the presence of exogenous glucose or lactate. The addition of oxamate to preparations suspended in a medium with lactate as the sole external substrate ameliorates the depression of uterine motility elicited by arsenite. © 1979 Birkhäuser Verlag.
Documento: | Artículo |
Título: | Effects of arsenite and oxamate on the in vitro functional activity of estrogen-dominated rat uterine horns |
Autor: | Gimeno, A.L.; Goldraij, A.; Gimeno, M.F. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas, Obligado 2490, Buenos Aires, 1428, Argentina Departamento de Fisiología, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina |
Palabras clave: | arsenic trioxide; arsenite sodium; estrogen; oxamic acid; oxytocin; amino acid; arsenic; estrogen; glucose; lactate dehydrogenase; lactic acid derivative; oxamic acid; oxytocin; animal experiment; female genital system; in vitro study; oxamate sodium; rat; uterus contractility; uterus contraction; uterus horn; animal; article; chemical phenomena; citric acid cycle; drug effect; female; metabolism; uterus; uterus contraction; Amino Acids; Animal; Arsenic; Citric Acid Cycle; Depression, Chemical; Estrogens; Female; Glucose; Lactate Dehydrogenase; Lactates; Oxamic Acid; Oxytocin; Rats; Uterine Contraction; Uterus |
Año: | 1979 |
Volumen: | 35 |
Número: | 2 |
Página de inicio: | 221 |
Página de fin: | 222 |
DOI: | http://dx.doi.org/10.1007/BF01920628 |
Título revista: | Experientia |
Título revista abreviado: | Experientia |
ISSN: | 00144754 |
CODEN: | EXPEA |
CAS: | arsenic trioxide, 1303-24-8, 1327-53-3, 13464-58-9, 15502-74-6; arsenite sodium, 13464-37-4; oxamic acid, 471-47-6; oxytocin, 50-56-6, 54577-94-5; amino acid, 65072-01-7; arsenic, 7440-38-2; glucose, 50-99-7, 84778-64-3; lactate dehydrogenase, 9001-60-9; Amino Acids; Arsenic, 7440-38-2; Estrogens; Glucose, 50-99-7; Lactate Dehydrogenase, EC 1.1.1.27; Lactates; Oxamic Acid, 471-47-6; Oxytocin, 50-56-6 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v35_n2_p221_Gimeno |