Artículo
Abstract:
Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we evaluated 37 consecutive patients with complex partial seizures exposed to monotherapy with phenytoin (PHT, carbamazepine (CBZ) or valproic acid (VPA). All had normal IQ and no congenital disturbances in colour vision or ocular diseases. Twenty normal controls were used for statistical analysis. Thirteen patients were exposed to PHT, 12 to CBZ and 12 to VPA. Visual colour perception was impaired in 30/37 (82%) of the study group. The most significant abnormality was detected in the blue-yellow axis in 10/13 patients exposed to PHT (p < 0.02) and in 8/12 treated with CBZ (p < 0.009). In 8/12 patients taking VPA, no significant abnormality was observed (p < 0.06). None of the studied patients complained of colour vision disturbances. Our findings strongly support the negative effect of AEDs upon colour vision discrimination, most likely due to changes at the retinal processing level. F-100 proved to be very useful to assess early toxicity due to AEDs.
Registro:
| Documento: | Artículo |
| Título: | Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| Autor: | López, L.; Thomson, A.; Rabinowicz, A.L. |
| Filiación: | Neurology Department, Raul Carrea Inst. for Neurol. Res., Buenos Aires, Argentina Neurology Service, British Hospital, Buenos Aires, Argentina Secc. Neuro-oftalmología, Inst. Invest. Neurologicas Raul C., Montañeses 2325, 1428 Buenos Aires, Argentina |
| Palabras clave: | Colour discrimination; Epileptic patients; Farnsworth-Munsell 100-hue test; anticonvulsive agent; carbamazepine; phenytoin; valproic acid; adolescent; adult; aged; article; clinical article; color vision defect; controlled study; epilepsy; female; filter; human; male; priority journal; vision test; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Color Perception; Color Vision Defects; Diplopia; Epilepsy, Complex Partial; Female; Humans; Male; Middle Aged; Phenytoin; Severity of Illness Index; Single-Blind Method; Valproic Acid |
| Año: | 1999 |
| Volumen: | 41 |
| Número: | 4 |
| Página de inicio: | 201 |
| Página de fin: | 205 |
| DOI: | http://dx.doi.org/10.1159/000008051 |
| Título revista: | European Neurology |
| Título revista abreviado: | Eur. Neurol. |
| ISSN: | 00143022 |
| CODEN: | EUNEA |
| CAS: | Anticonvulsants; Carbamazepine, 298-46-4; Phenytoin, 57-41-0; Valproic Acid, 99-66-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00143022_v41_n4_p201_Lopez |
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Citas:
---------- APA ----------
López, L., Thomson, A. & Rabinowicz, A.L. (1999) . Assessment of colour vision in epileptic patients exposed to single-drug therapy. European Neurology, 41(4), 201-205.http://dx.doi.org/10.1159/000008051
---------- CHICAGO ----------
López, L., Thomson, A., Rabinowicz, A.L. "Assessment of colour vision in epileptic patients exposed to single-drug therapy" . European Neurology 41, no. 4 (1999) : 201-205.http://dx.doi.org/10.1159/000008051
---------- MLA ----------
López, L., Thomson, A., Rabinowicz, A.L. "Assessment of colour vision in epileptic patients exposed to single-drug therapy" . European Neurology, vol. 41, no. 4, 1999, pp. 201-205.http://dx.doi.org/10.1159/000008051
---------- VANCOUVER ----------
López, L., Thomson, A., Rabinowicz, A.L. Assessment of colour vision in epileptic patients exposed to single-drug therapy. Eur. Neurol. 1999;41(4):201-205.http://dx.doi.org/10.1159/000008051
