Artículo

Gimeno, M.F.; Landa, A.; Sterin-Speziale, N.; Cardinali, D.P.; Gimeno, A.L. "Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus" (1980) European Journal of Pharmacology. 62(4):309-317
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Abstract:

The effects of melatonin on the motility (isometric tension developed and contractile frequency) of uterine horns isolated from ovariectomized rats as well as on the mechanical responsiveness to added oxytocin or prostaglandin F2α (PGF2α) were explored. The pineal indole (10-6 or higher) depressed significantly the spontaneous motility of the uterus and reduced the responses evoked by oxytocin but not those evoked by PGF2α. Melatonin was also tested on the prostaglandin (PG) release into the suspending media from either uterine horns from spayed rats or bovine medial basal hypothalamic (MBH) explants. Melatonin (10-3 M) diminished the output from the uterus or the MNH of both PGE and PGF-'like material'. Similarities between the effects of melatonin and indomethacin as well as the possible physiological relevance of the present findings are discussed. © 1980.

Registro:

Documento: Artículo
Título:Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus
Autor:Gimeno, M.F.; Landa, A.; Sterin-Speziale, N.; Cardinali, D.P.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Contractile activity; Hypothalamus; Melatonin; Prostaglandins; Uterine motility; indometacin; melatonin; oxytocin; prostaglandin; prostaglandin f2 alpha; animal experiment; cattle; female genital system; hypothalamus; in vitro study; rat; uterus contraction; Animals; Castration; Female; Hypothalamus; Indomethacin; Luteinizing Hormone; Melatonin; Neurotransmitter Agents; Oxytocin; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Uterine Contraction; Uterus
Año:1980
Volumen:62
Número:4
Página de inicio:309
Página de fin:317
DOI: http://dx.doi.org/10.1016/0014-2999(80)90098-9
Título revista:European Journal of Pharmacology
Título revista abreviado:Eur. J. Pharmacol.
ISSN:00142999
CODEN:EJPHA
CAS:indometacin, 53-86-1, 74252-25-8, 7681-54-1; melatonin, 73-31-4; oxytocin, 50-56-6, 54577-94-5; prostaglandin F2 alpha, 551-11-1; Indomethacin, 53-86-1; Luteinizing Hormone, 9002-67-9; Melatonin, 73-31-4; Neurotransmitter Agents; Oxytocin, 50-56-6; Prostaglandins; Prostaglandins E; Prostaglandins F
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v62_n4_p309_Gimeno

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Citas:

---------- APA ----------
Gimeno, M.F., Landa, A., Sterin-Speziale, N., Cardinali, D.P. & Gimeno, A.L. (1980) . Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus. European Journal of Pharmacology, 62(4), 309-317.
http://dx.doi.org/10.1016/0014-2999(80)90098-9
---------- CHICAGO ----------
Gimeno, M.F., Landa, A., Sterin-Speziale, N., Cardinali, D.P., Gimeno, A.L. "Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus" . European Journal of Pharmacology 62, no. 4 (1980) : 309-317.
http://dx.doi.org/10.1016/0014-2999(80)90098-9
---------- MLA ----------
Gimeno, M.F., Landa, A., Sterin-Speziale, N., Cardinali, D.P., Gimeno, A.L. "Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus" . European Journal of Pharmacology, vol. 62, no. 4, 1980, pp. 309-317.
http://dx.doi.org/10.1016/0014-2999(80)90098-9
---------- VANCOUVER ----------
Gimeno, M.F., Landa, A., Sterin-Speziale, N., Cardinali, D.P., Gimeno, A.L. Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus. Eur. J. Pharmacol. 1980;62(4):309-317.
http://dx.doi.org/10.1016/0014-2999(80)90098-9