Abstract:
Anandamide (0.01 to 10 μM) caused greater concentration-dependent reductions of the contractile-induced responses to noradrenaline in female than in male mesenteric vascular beds isolated from adult Sprague-Dawley rats. Greater relaxant responses in females were also induced by the vanilloid TRPV1 receptor agonist capsaicin (0.01 to 10 μM), whereas no sex differences were observed for the relaxations caused by either acetylcholine or sodium nitroprusside. The effect of anandamide in either sex was reduced by the vanilloid TRPV1 receptor antagonist capsazepine but not by the cannabinoid CB1 receptor antagonist N-piperidino-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-3-pyrazole-carboxamide (SR141716A). In males, the anandamide-induced relaxations were potentiated by in vitro exposure during 5 min to 0.5 μM 17β-oestradiol and unmodified by the protein synthesis inhibitor cycloheximide. The vasorelaxant effects of anandamide in female rats were decreased by ovariectomy. This decrease was prevented by in vivo treatment with 17β-oestradiol-3-benzoate (450 μg/kg i.m., once a week during 3 weeks) and counteracted by in vitro exposure to oestrogen. In vivo treatment with 17β-oestradiol also potentiated anandamide-induced responses in males. In conclusion, this study shows an oestrogen-dependent sensitivity to the vanilloid TRPV1 receptor-mediated vasorelaxant effects of anandamide in the mesenteric vasculature of Sprague-Dawley rats, that could be mediated by both genomic and non-genomic mechanisms. © 2004 Elsevier B.V. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: Role of oestrogens |
Autor: | Peroni, R.N.; Orliac, M.L.; Becu-Villalobos, D.; Huidobro-Toro, J.P.; Adler-Graschinsky, E.; Celuch, S.M. |
Filiación: | Inst. de Invest. Farmacologicas, Junín 956, 1113 Buenos Aires, Argentina Inst. de Biol. Y Med. Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina U. de Regulación Neurohumoral, Depto. de Cie. Fisiológicas, Pont. Univ. Católica de Chile, Santiago de Chile, Chile
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Palabras clave: | (Sprague-Dawley rat); 17β-Oestradiol; Anandamide; Sex difference; Vasorelaxation; acetylcholine; anandamide; cannabinoid 1 receptor; cannabinoid receptor antagonist; capsaicin; capsazepine; cycloheximide; estradiol; estradiol benzoate; estrogen; nitroprusside sodium; noradrenalin; protein synthesis inhibitor; rimonabant; vanilloid receptor; animal experiment; animal tissue; article; blood vessel; concentration response; controlled study; dose response; drug effect; estrogen activity; exposure; female; in vitro study; isolated organ; male; muscle contractility; nonhuman; ovariectomy; priority journal; rat; sex difference; vasodilatation; Acetylcholine; Animals; Arachidonic Acids; Argentina; Capsaicin; Chile; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Estrogens; Female; Male; Mesentery; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Ovariectomy; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Sex Characteristics; Time Factors; Vasodilation |
Año: | 2004
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Volumen: | 493
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Número: | 1-3
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Página de inicio: | 151
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Página de fin: | 160
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DOI: |
http://dx.doi.org/10.1016/j.ejphar.2004.04.031 |
Título revista: | European Journal of Pharmacology
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Título revista abreviado: | Eur. J. Pharmacol.
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ISSN: | 00142999
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CODEN: | EJPHA
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CAS: | acetylcholine, 51-84-3, 60-31-1, 66-23-9; anandamide, 94421-68-8; capsaicin, 404-86-4; capsazepine, 138977-28-3; cycloheximide, 642-81-9, 66-81-9; estradiol benzoate, 50-50-0; estradiol, 50-28-2; nitroprusside sodium, 14402-89-2, 15078-28-1; noradrenalin, 1407-84-7, 51-41-2; rimonabant, 158681-13-1, 168273-06-1; Acetylcholine, 51-84-3; anandamide, 94421-68-8; Arachidonic Acids; Capsaicin, 404-86-4; capsazepine; Cycloheximide, 66-81-9; estradiol 3-benzoate, 50-50-0; Estradiol, 50-28-2; Estrogens; Nitroprusside, 15078-28-1; Norepinephrine, 51-41-2; Phenylmethylsulfonyl Fluoride, 329-98-6; Piperidines; Polyunsaturated Alkamides; Pyrazoles; SR 141716A, 158681-13-1
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v493_n1-3_p151_Peroni |
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Citas:
---------- APA ----------
Peroni, R.N., Orliac, M.L., Becu-Villalobos, D., Huidobro-Toro, J.P., Adler-Graschinsky, E. & Celuch, S.M.
(2004)
. Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: Role of oestrogens. European Journal of Pharmacology, 493(1-3), 151-160.
http://dx.doi.org/10.1016/j.ejphar.2004.04.031---------- CHICAGO ----------
Peroni, R.N., Orliac, M.L., Becu-Villalobos, D., Huidobro-Toro, J.P., Adler-Graschinsky, E., Celuch, S.M.
"Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: Role of oestrogens"
. European Journal of Pharmacology 493, no. 1-3
(2004) : 151-160.
http://dx.doi.org/10.1016/j.ejphar.2004.04.031---------- MLA ----------
Peroni, R.N., Orliac, M.L., Becu-Villalobos, D., Huidobro-Toro, J.P., Adler-Graschinsky, E., Celuch, S.M.
"Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: Role of oestrogens"
. European Journal of Pharmacology, vol. 493, no. 1-3, 2004, pp. 151-160.
http://dx.doi.org/10.1016/j.ejphar.2004.04.031---------- VANCOUVER ----------
Peroni, R.N., Orliac, M.L., Becu-Villalobos, D., Huidobro-Toro, J.P., Adler-Graschinsky, E., Celuch, S.M. Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: Role of oestrogens. Eur. J. Pharmacol. 2004;493(1-3):151-160.
http://dx.doi.org/10.1016/j.ejphar.2004.04.031