Artículo
Cardinali, D.P. "Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain" (1978) European Journal of Pharmacology. 47(2):239-243
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Abstract:
In the brain of rats injected with pentoxifylline [3,7-dimethyl-1(5-oxo-hexyl)-xanthine] or aminophylline the following was observed: (i) dose-dependent increases of tryptophan and 5-droxyindoleacetic acid levels and of 5-hydroxytryptophan and dihydroxyphenylalanine accumulation after treatment with the decarboxylase inhibitor benserazide HCl; (ii) acceleration of norepinephrine turnover following α-methyl-p-tyrosine; (iii) increase of 3-methoxytyramine accumulation following pargyline. On a molar basis pentoxifylline was more potent than aminophylline in affecting brain biogenic amine metabolism. © 1978.
Registro:
| Documento: | Artículo |
| Título: | Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
| Autor: | Cardinali, D.P. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (Cefaprin), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina, Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | 5-Hydroxyindoleacetic acid; Aminophylline; Catecholamine turnover; Methylxanthines; Tryptophan and tyrosine hydroxylation; 5 hydroxyindoleacetic acid; 5 hydroxytryptophan; amine; aminophylline; benserazide; catecholamine; dopa; metirosine; pargyline; pentoxifylline; serotonin; tryptophan; tryptophan hydroxylase; tyrosine 3 monooxygenase; animal experiment; brain; catecholamine brain level; catecholamine metabolism; central nervous system; column chromatography; controlled study; dose response; dose time effect relation; double blind procedure; drug analysis; drug comparison; drug efficacy; drug response; in vitro study; intraperitoneal drug administration; methodology; rat; Aminophylline; Animal; Biogenic Amines; Brain; Dopamine; Male; Norepinephrine; Pentoxifylline; Rats; Serotonin; Theobromine |
| Año: | 1978 |
| Volumen: | 47 |
| Número: | 2 |
| Página de inicio: | 239 |
| Página de fin: | 243 |
| DOI: | http://dx.doi.org/10.1016/0014-2999(78)90397-7 |
| Título revista: | European Journal of Pharmacology |
| Título revista abreviado: | Eur. J. Pharmacol. |
| ISSN: | 00142999 |
| CODEN: | EJPHA |
| CAS: | 5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; 5 hydroxytryptophan, 4350-09-8, 56-69-9; aminophylline, 317-34-0; benserazide, 14919-77-8, 322-35-0; DOPA, 587-45-1; metirosine, 672-87-7; pargyline, 306-07-0, 555-57-7; pentoxifylline, 6493-05-6; serotonin, 50-67-9; tryptophan hydroxylase, 9037-21-2; tryptophan, 6912-86-3, 73-22-3; tyrosine 3 monooxygenase, 9036-22-0; Aminophylline, 317-34-0; Biogenic Amines; Dopamine, 51-61-6; Norepinephrine, 51-41-2; Pentoxifylline, 6493-05-6; Serotonin, 50-67-9; Theobromine, 83-67-0 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v47_n2_p239_Cardinali |
Referencias:
- Berkowitz, Tarver, Spector, Release of norepinephrine in the central nervous system by theophylline and caffeine (1970) European J. Pharmacol., 10, p. 64
- Cardinali, Effects of pentoxifylline and theophylline on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus (1977) Neuropharmacol., , (in press)
- Carlsson, Davis, Kehr, Lindqvist, Atack, Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase (1972) Naunyn-Schmiedeb. Arch. Pharmacol., 275, p. 153
- Corrodi, Fuxe, Jonsson, Effects of caffeine on central monoamine neurons (1972) J. Pharm. Pharmacol., 24, p. 155
- Curzon, Fernando, Effect of aminophylline on tryptophan and other aromatic amino acids in plasma, brain and other tissues and on brain 5-hydroxytryptamine metabolism (1976) Brit. J. Pharmacol., 58, p. 533
- Hyyppä M.T.,D.P. Cardinali,H.G. Baumgarten and R.J. Wurtman, Rapid accumulation of 3H-serotonin in brain of rats receiving intraperitoneal 3H-tryptophan: effects of 5,6-dihydroxytryptamine or female sex hormones, J. Neural Transm. 34, 111; Karasawa, Furukawa, Yoshida, Shimizu, Effect of theophylline on monoamine metabolism in the rat brain (1976) European J. Pharmacol., 37, p. 97
- Laverty, Taylor, The flurometric assay of catecholamines and related compounds: Improvements and extensions to the hydroxy-indole technique (1968) Anal. Biochem., 22, p. 269
- Waalkes, Udenfriend, A fluorometric method for the estimation of tyrosine in plasma and tissues (1957) J. Lab. Clin. Med., 50, p. 733
- Waldeck, Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain (1971) J. Pharm. Pharmacol., 23, p. 824
Citas:
---------- APA ----------
(1978) . Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain. European Journal of Pharmacology, 47(2), 239-243.http://dx.doi.org/10.1016/0014-2999(78)90397-7
---------- CHICAGO ----------
Cardinali, D.P. "Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain" . European Journal of Pharmacology 47, no. 2 (1978) : 239-243.http://dx.doi.org/10.1016/0014-2999(78)90397-7
---------- MLA ----------
Cardinali, D.P. "Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain" . European Journal of Pharmacology, vol. 47, no. 2, 1978, pp. 239-243.http://dx.doi.org/10.1016/0014-2999(78)90397-7
---------- VANCOUVER ----------
Cardinali, D.P. Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain. Eur. J. Pharmacol. 1978;47(2):239-243.http://dx.doi.org/10.1016/0014-2999(78)90397-7
