In the brain of rats injected with pentoxifylline [3,7-dimethyl-1(5-oxo-hexyl)-xanthine] or aminophylline the following was observed: (i) dose-dependent increases of tryptophan and 5-droxyindoleacetic acid levels and of 5-hydroxytryptophan and dihydroxyphenylalanine accumulation after treatment with the decarboxylase inhibitor benserazide HCl; (ii) acceleration of norepinephrine turnover following α-methyl-p-tyrosine; (iii) increase of 3-methoxytyramine accumulation following pargyline. On a molar basis pentoxifylline was more potent than aminophylline in affecting brain biogenic amine metabolism. © 1978.
Documento: | Artículo |
Título: | Effect of pentoxifylline and aminophylline on biogenic amine metabolism of the rat brain |
Autor: | Cardinali, D.P. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (Cefaprin), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina, Obligado 2490, 1428 Buenos Aires, Argentina |
Palabras clave: | 5-Hydroxyindoleacetic acid; Aminophylline; Catecholamine turnover; Methylxanthines; Tryptophan and tyrosine hydroxylation; 5 hydroxyindoleacetic acid; 5 hydroxytryptophan; amine; aminophylline; benserazide; catecholamine; dopa; metirosine; pargyline; pentoxifylline; serotonin; tryptophan; tryptophan hydroxylase; tyrosine 3 monooxygenase; animal experiment; brain; catecholamine brain level; catecholamine metabolism; central nervous system; column chromatography; controlled study; dose response; dose time effect relation; double blind procedure; drug analysis; drug comparison; drug efficacy; drug response; in vitro study; intraperitoneal drug administration; methodology; rat; Aminophylline; Animal; Biogenic Amines; Brain; Dopamine; Male; Norepinephrine; Pentoxifylline; Rats; Serotonin; Theobromine |
Año: | 1978 |
Volumen: | 47 |
Número: | 2 |
Página de inicio: | 239 |
Página de fin: | 243 |
DOI: | http://dx.doi.org/10.1016/0014-2999(78)90397-7 |
Título revista: | European Journal of Pharmacology |
Título revista abreviado: | Eur. J. Pharmacol. |
ISSN: | 00142999 |
CODEN: | EJPHA |
CAS: | 5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; 5 hydroxytryptophan, 4350-09-8, 56-69-9; aminophylline, 317-34-0; benserazide, 14919-77-8, 322-35-0; DOPA, 587-45-1; metirosine, 672-87-7; pargyline, 306-07-0, 555-57-7; pentoxifylline, 6493-05-6; serotonin, 50-67-9; tryptophan hydroxylase, 9037-21-2; tryptophan, 6912-86-3, 73-22-3; tyrosine 3 monooxygenase, 9036-22-0; Aminophylline, 317-34-0; Biogenic Amines; Dopamine, 51-61-6; Norepinephrine, 51-41-2; Pentoxifylline, 6493-05-6; Serotonin, 50-67-9; Theobromine, 83-67-0 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v47_n2_p239_Cardinali |