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Abstract:

The effect of baclofen, β-(4-chlorophenyl)GABA, on prolactin secretion was investigated in rats under several experimental conditions. In adult male rats subjected either to immobilization, ether, swimming or cold stress there was a rapid increase of serum prolactin levels; acute pretreatment with baclofen, 10 mg/kg i.p. inhibited the hormone response to all these stresses. The same blocking effect of the drug was observed in prepubertal male and female rats and in adult gonadectomized animals. In basal conditions, i.e. in undisturbed male rats, baclofen did not change the hormone titers significantly. Taken together our results indicate that baclofen blocks prolactin release when release of the hormone is dynamically stimulated by stress and this effect is relatively independent of the endocrine status of the rat. © 1986.

Registro:

Documento: Artículo
Título:Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat
Autor:D'eramo, JosL.; Somoza, G.M.; Kertesz, E.; Libertun, C.
Filiación:Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Baclofen; Prolactin; Stress; baclofen; animal experiment; central nervous system; drug efficacy; endocrine system; hypophysis; intraperitoneal drug administration; nonhuman; priority journal; prolactin release; rat; stress; Animal; Baclofen; Bicuculline; Cold; Female; Male; Ovariectomy; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Restraint, Physical; Stress; Support, Non-U.S. Gov't; Swimming
Año:1986
Volumen:120
Número:1
Página de inicio:81
Página de fin:85
DOI: http://dx.doi.org/10.1016/0014-2999(86)90643-6
Título revista:European Journal of Pharmacology
Título revista abreviado:Eur. J. Pharmacol.
ISSN:00142999
CODEN:EJPHA
CAS:baclofen, 1134-47-0; Baclofen, 1134-47-0; Bicuculline, 485-49-4; Prolactin, 9002-62-4; Receptors, GABA-A
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v120_n1_p81_Deramo

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Citas:

---------- APA ----------
D'eramo, JosL., Somoza, G.M., Kertesz, E. & Libertun, C. (1986) . Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat. European Journal of Pharmacology, 120(1), 81-85.
http://dx.doi.org/10.1016/0014-2999(86)90643-6
---------- CHICAGO ----------
D'eramo, JosL., Somoza, G.M., Kertesz, E., Libertun, C. "Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat" . European Journal of Pharmacology 120, no. 1 (1986) : 81-85.
http://dx.doi.org/10.1016/0014-2999(86)90643-6
---------- MLA ----------
D'eramo, JosL., Somoza, G.M., Kertesz, E., Libertun, C. "Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat" . European Journal of Pharmacology, vol. 120, no. 1, 1986, pp. 81-85.
http://dx.doi.org/10.1016/0014-2999(86)90643-6
---------- VANCOUVER ----------
D'eramo, JosL., Somoza, G.M., Kertesz, E., Libertun, C. Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat. Eur. J. Pharmacol. 1986;120(1):81-85.
http://dx.doi.org/10.1016/0014-2999(86)90643-6