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Abstract:

59Fe was incorporated in vivo into intestinal sacs prepared in iron deficient rats and 59Fe counts were detected in blood, spleen, liver, femur and intestine. The i.v. injection of isoproterenol (i.v. 2 μg/rat) or N′,O′-dibutyryladenosine 3′,5′-cyclic monophosphate (10 μM/100 g b.w.) enhanced significantly the iron counts in blood, spleen, liver and femur but not in intestine. (-)-Propranolol (2 mg · kg-1 b.w.i.v.) antagonized the stimulatory effect of isoproterenol. It is suggested that isoproterenol increases iron absorption via the stimulation of β-adrenoreceptors of the intestinal mucosa. © 1984.

Registro:

Documento: Artículo
Título:Are β-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?
Autor:Gutnisky, A.; Borda, E.S.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Serrano 665/669, 1414 Buenos Aires, Argentina
Palabras clave:5′-cyclic monophosphate; Adrenoreceptors; Iron absorption; Iron distribution; Isoproterenol; N′; O′-Dibutyryladenosine 3′; Propranolol; beta adrenergic receptor; bucladesine; iron; iron 59; isoprenaline; propranolol; radioisotope; animal experiment; digestive system; drug absorption; drug distribution; intestine absorption; intestine mucosa; nonhuman; oral drug administration; rat; small intestine; tissue distribution; Animal; Bucladesine; Intestinal Absorption; Iron; Iron Radioisotopes; Isoproterenol; Male; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't; Tissue Distribution
Año:1984
Volumen:100
Número:3-4
Página de inicio:369
Página de fin:372
DOI: http://dx.doi.org/10.1016/0014-2999(84)90015-3
Título revista:European Journal of Pharmacology
Título revista abreviado:Eur. J. Pharmacol.
ISSN:00142999
CODEN:EJPHA
CAS:bucladesine, 16980-89-5, 362-74-3; iron 59, 14596-12-4; iron, 14093-02-8, 53858-86-9, 7439-89-6; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Bucladesine, 362-74-3; Iron Radioisotopes; Iron, 7439-89-6; Isoproterenol, 7683-59-2; Propranolol, 525-66-6; Receptors, Adrenergic, beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v100_n3-4_p369_Gutnisky

Referencias:

  • Borda, del C. Agostini, Gimeno, Gimeno, Selective stimulation of PGE1 synthesis by soterenol in the isolated rat vas deferens is mediated by alpha adrenoreceptors (1982) Prost. Leukotr. Med., 8, p. 531
  • Borda, Sterin-Borda, Gimeno, Lazzari, Gimeno, Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors? (1983) Experientia, 39, p. 894
  • Chaud, Borda, Franchi, Sterin-Borda, Gimeno, Gimeno, Prostaglandin F2-alpha modifies the action of norepinephrine on alpha and beta adrenoreceptors of isolated rat uterus (1982) European J. Pharmacol., 78, p. 449
  • Fernandez Pardal, Gimeno, Gimeno, Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectomized animals (1982) Prostaglandins, Leukotrienes and Medicine, 9, p. 341
  • Floss, Armario, Stress stimulation and iron metabolism: adrenaline administration (1976) Rev. Esp. Fisiol., 34, p. 167
  • Glickman, Gutnisky, Gimeno, Gimeno, Effect of acetylsalicylic acid on iron absorption in the rat (1981) Experientia, 37, p. 589
  • Gutnisky, Speziale, Gimeno, Gimeno, Direct evidence favouring the notion that erythropoietin alters iron transport across the isolated intestinal tract of the rat (1979) Experientia, 35, p. 623
  • Gutnisky, Glickman, Gimeno, Gimeno, Effect of 15 (R)-15-methyl-prostaglandin E2 on iron absorption in the rat (1982) Experientia, 38, p. 116
  • Thomson, Valberg, Passage of iron out of the intestinal mucosa of the rat (1980) Can. J. Physiol. Pharmacol., 58, p. 129
  • Wagner, Fortier, Giroux, Lukes, Snyder, Catecholamines in adult iron deficiency patients (1979) Experientia, 35, p. 681

Citas:

---------- APA ----------
Gutnisky, A., Borda, E.S. & Gimeno, A.L. (1984) . Are β-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?. European Journal of Pharmacology, 100(3-4), 369-372.
http://dx.doi.org/10.1016/0014-2999(84)90015-3
---------- CHICAGO ----------
Gutnisky, A., Borda, E.S., Gimeno, A.L. "Are β-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?" . European Journal of Pharmacology 100, no. 3-4 (1984) : 369-372.
http://dx.doi.org/10.1016/0014-2999(84)90015-3
---------- MLA ----------
Gutnisky, A., Borda, E.S., Gimeno, A.L. "Are β-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?" . European Journal of Pharmacology, vol. 100, no. 3-4, 1984, pp. 369-372.
http://dx.doi.org/10.1016/0014-2999(84)90015-3
---------- VANCOUVER ----------
Gutnisky, A., Borda, E.S., Gimeno, A.L. Are β-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?. Eur. J. Pharmacol. 1984;100(3-4):369-372.
http://dx.doi.org/10.1016/0014-2999(84)90015-3