Artículo
Tomio, J.M.; Grinstein, M. "Porphyrin Biosynthesis: 5. Biosynthesis of Protoporphyrin IX in Harderian Glands" (1968) European Journal of Biochemistry. 6(1):80-83
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Abstract:
The enzymic system that catalyzes the total synthesis of protoporphyrin IX has been found in the Harderian gland of the rat. The presence of the enzyme δ‐aminolevulinic acid synthetase was demonstrated in mitochondria by the formation of [14C]δ‐aminolevulinic acid. On incubation of homogenates of the Harderian glands with δ‐aminolevulinic acid and porphobilinogen, varying conditions such as temperature, time, aero‐or anaerobiosis and cofactor and substrate concentration, porphyrins with a carboxyl content ranging from 8–2 were formed. Thus, the presence of δ‐aminolevulinate dehydratase, porphobilinogenase, decarboxylase and coproporphyrinogenase systems were demonstrated. Copyright © 1968, Wiley Blackwell. All rights reserved
Registro:
| Documento: | Artículo |
| Título: | Porphyrin Biosynthesis: 5. Biosynthesis of Protoporphyrin IX in Harderian Glands |
| Autor: | Tomio, J.M.; Grinstein, M. |
| Filiación: | Departamento de Química Biológica, Laboratorio de Química Biológica I, Facultad de Ciencias Exactas y Naturales, Perú 272, Buenos Aires, Argentina |
| Palabras clave: | amino acid; carbon; coenzyme A; glycine; levulinic acid; ligase; porphyrin; succinic acid derivative; animal; article; biosynthesis; enzymology; lacrimal apparatus; male; metabolism; mitochondrion; nictitating membrane; rat; Amino Acids; Animal; Carbon Isotopes; Coenzyme A; Glycine; Lacrimal Apparatus; Levulinic Acids; Ligases; Male; Mitochondria; Nictitating Membrane; Porphyrins; Rats; Succinates |
| Año: | 1968 |
| Volumen: | 6 |
| Número: | 1 |
| Página de inicio: | 80 |
| Página de fin: | 83 |
| DOI: | http://dx.doi.org/10.1111/j.1432-1033.1968.tb00421.x |
| Título revista: | European Journal of Biochemistry |
| Título revista abreviado: | Eur. J. Biochem. |
| ISSN: | 00142956 |
| CAS: | amino acid, 65072-01-7; carbon, 7440-44-0; coenzyme A, 85-61-0; glycine, 56-40-6, 6000-43-7, 6000-44-8; levulinic acid, 123-76-2; ligase, 9080-13-1; porphyrin, 24869-67-8; Amino Acids; Carbon Isotopes; Coenzyme A, 85-61-0; Glycine, 56-40-6; Levulinic Acids; Ligases, EC 6.; Porphyrins; Succinates |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142956_v6_n1_p80_Tomio |
Citas:
---------- APA ----------
Tomio, J.M. & Grinstein, M. (1968) . Porphyrin Biosynthesis: 5. Biosynthesis of Protoporphyrin IX in Harderian Glands. European Journal of Biochemistry, 6(1), 80-83.http://dx.doi.org/10.1111/j.1432-1033.1968.tb00421.x
---------- CHICAGO ----------
Tomio, J.M., Grinstein, M. "Porphyrin Biosynthesis: 5. Biosynthesis of Protoporphyrin IX in Harderian Glands" . European Journal of Biochemistry 6, no. 1 (1968) : 80-83.http://dx.doi.org/10.1111/j.1432-1033.1968.tb00421.x
---------- MLA ----------
Tomio, J.M., Grinstein, M. "Porphyrin Biosynthesis: 5. Biosynthesis of Protoporphyrin IX in Harderian Glands" . European Journal of Biochemistry, vol. 6, no. 1, 1968, pp. 80-83.http://dx.doi.org/10.1111/j.1432-1033.1968.tb00421.x
---------- VANCOUVER ----------
Tomio, J.M., Grinstein, M. Porphyrin Biosynthesis: 5. Biosynthesis of Protoporphyrin IX in Harderian Glands. Eur. J. Biochem. 1968;6(1):80-83.http://dx.doi.org/10.1111/j.1432-1033.1968.tb00421.x
