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Abstract:

The synthesis of phosphatidyl‐dCMP in mouse thymocytes is inhibited by the antineoplastic agent 1‐β‐d‐arabinofuranosyl cytosine (AraCyt)50% inhibition (ID50) being reached at an AraCyt concentration of 0.18 mM. IN the same cells, ID50 for DNA synthesis is 0.03 mM. This inhibition is probably mediated by the phosphorylated derivative of AraCyt (aCTP) since the synthesis of phosphatidyl‐dCMP from dCTP using permeabilized thymocytes is inhibited by a aCTP (ID50= 0.11 mM). The incorporatioin of [3H]AraCyt inbto the organic phase could also be detected, suggesting that this drug may act as a substrate for the enzyme that catalyzes the transfer of dCTP into phosphatidic acid. Copyright © 1983, Wiley Blackwell. All rights reserved

Registro:

Documento: Artículo
Título:Inhibitory Effect of 1‐β‐d‐Arabinofuranosylcytosine on the Synthesis of Phosphatidyl‐dCMP
Autor:IUJVIDIN, S.; FELEDI, C.; MEDRANO, E.E.; MORDOH, J.
Filiación:Instituto de Investigaciones Bioquímicas "Fundacion Campomar", Obligado 2490, Buenos Aires, RA-1428, Argentina
Seccion de Oncologia Diagnostica, Policlinico Mariano R. Castex, RA‐1650 San Martin, San Martin, Prov. de Buenos Aires, RA-1650, Argentina
Facultad de Ciencias Exactas Y Naturales, Instituto de Investigaciones Bioquimicas “Fundacion Campomar”, Obligado 2490, Buenos Aires, RA-1428, Argentina
Palabras clave:cytarabine; deoxyribonuclease; radioisotope; cancer chemotherapy; drug inhibition; in vitro study; mouse; nonhuman; phosphatidyldeoxycytidine phosphate; therapy; thymocyte; thymus; Animal; Cytarabine; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; In Vitro; Mice; Mice, Inbred BALB C; Support, Non-U.S. Gov't; Thymus Gland
Año:1983
Volumen:130
Número:2
Página de inicio:293
Página de fin:296
DOI: http://dx.doi.org/10.1111/j.1432-1033.1983.tb07150.x
Título revista:European Journal of Biochemistry
Título revista abreviado:Eur. J. Biochem.
ISSN:00142956
CAS:cytarabine, 147-94-4, 69-74-9; deoxyribonuclease, 37211-67-9; Cytarabine, 147-94-4; Deoxycytidine Monophosphate, 1032-65-1; Deoxycytosine Nucleotides; phosphatidyl-dCMP
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142956_v130_n2_p293_IUJVIDIN

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Citas:

---------- APA ----------
IUJVIDIN, S., FELEDI, C., MEDRANO, E.E. & MORDOH, J. (1983) . Inhibitory Effect of 1‐β‐d‐Arabinofuranosylcytosine on the Synthesis of Phosphatidyl‐dCMP. European Journal of Biochemistry, 130(2), 293-296.
http://dx.doi.org/10.1111/j.1432-1033.1983.tb07150.x
---------- CHICAGO ----------
IUJVIDIN, S., FELEDI, C., MEDRANO, E.E., MORDOH, J. "Inhibitory Effect of 1‐β‐d‐Arabinofuranosylcytosine on the Synthesis of Phosphatidyl‐dCMP" . European Journal of Biochemistry 130, no. 2 (1983) : 293-296.
http://dx.doi.org/10.1111/j.1432-1033.1983.tb07150.x
---------- MLA ----------
IUJVIDIN, S., FELEDI, C., MEDRANO, E.E., MORDOH, J. "Inhibitory Effect of 1‐β‐d‐Arabinofuranosylcytosine on the Synthesis of Phosphatidyl‐dCMP" . European Journal of Biochemistry, vol. 130, no. 2, 1983, pp. 293-296.
http://dx.doi.org/10.1111/j.1432-1033.1983.tb07150.x
---------- VANCOUVER ----------
IUJVIDIN, S., FELEDI, C., MEDRANO, E.E., MORDOH, J. Inhibitory Effect of 1‐β‐d‐Arabinofuranosylcytosine on the Synthesis of Phosphatidyl‐dCMP. Eur. J. Biochem. 1983;130(2):293-296.
http://dx.doi.org/10.1111/j.1432-1033.1983.tb07150.x