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Abstract:

Purpose: Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal abnormalities in CBF beyond the temporal lobes has not been carefully addressed. Methods: We assessed 4 patients with pathologically proven unilateral TLE who had significant ipsilateral frontal hypoperfusion in ictal studies with no other abnormalities but chronic epilepsy accounting for such findings. Patients were assessed as candidates for surgery by interictal BEG. neuropsychological studies, brain magnetic resonance imaging, scalp electrode video-EEG monitoring, and ictal SPECT. Results: Characteristic hyperperfusion was evident over the temporal lobe ipsilateral to the EEG focus, with significant hypoperfusion over the frontal region in 3 patients. In patient 4, frontal hypoperfusion was not statistically significant. Conclusions: SPECT demonstrated relative rCBF changes beyond the epileptogenic zone in unilateral TLE. Our findings provide further insight into the pathophysiological changes underlying this condition.

Registro:

Documento: Artículo
Título:Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy
Autor:Rabinowicz, A.L.; Salas, E.; Beserra, F.; Leiguarda, R.C.; Vazquez, S.E.
Filiación:Department of Neurology, Raul Carrea Inst. for Neurol. Res., Fleni, Buenos Aires, Argentina
Dept. Nucl. Med., and Epilepsy Prog., Raul Carrea Inst. for Neurol. Res., Fleni, Buenos Aires, Argentina
Inst. Invest. Neurologicas Raul C., Montaneses 2325, 1428 Buenos Aires, Argentina
Palabras clave:Cerebral blood flow; Diaschisis; Temporal lobe epilepsy; adult; article; brain blood flow; case report; complex partial seizure; electroencephalogram; epilepsy; female; human; male; neuropsychological test; nuclear magnetic resonance imaging; priority journal; single photon emission computer tomography; temporal lobe; temporal lobe epilepsy; Adult; Cysteine; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Organotechnetium Compounds; Radiopharmaceuticals; Regional Blood Flow; Temporal Lobe; Tomography, Emission-Computed, Single-Photon
Año:1997
Volumen:38
Número:9
Página de inicio:1011
Página de fin:1014
DOI: http://dx.doi.org/10.1111/j.1528-1157.1997.tb01484.x
Título revista:Epilepsia
Título revista abreviado:EPILEPSIA
ISSN:00139580
CODEN:EPILA
CAS:Cysteine, 52-90-4; Organotechnetium Compounds; Radiopharmaceuticals; technetium Tc 99m bicisate
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00139580_v38_n9_p1011_Rabinowicz

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Citas:

---------- APA ----------
Rabinowicz, A.L., Salas, E., Beserra, F., Leiguarda, R.C. & Vazquez, S.E. (1997) . Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy. Epilepsia, 38(9), 1011-1014.
http://dx.doi.org/10.1111/j.1528-1157.1997.tb01484.x
---------- CHICAGO ----------
Rabinowicz, A.L., Salas, E., Beserra, F., Leiguarda, R.C., Vazquez, S.E. "Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy" . Epilepsia 38, no. 9 (1997) : 1011-1014.
http://dx.doi.org/10.1111/j.1528-1157.1997.tb01484.x
---------- MLA ----------
Rabinowicz, A.L., Salas, E., Beserra, F., Leiguarda, R.C., Vazquez, S.E. "Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy" . Epilepsia, vol. 38, no. 9, 1997, pp. 1011-1014.
http://dx.doi.org/10.1111/j.1528-1157.1997.tb01484.x
---------- VANCOUVER ----------
Rabinowicz, A.L., Salas, E., Beserra, F., Leiguarda, R.C., Vazquez, S.E. Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy. EPILEPSIA. 1997;38(9):1011-1014.
http://dx.doi.org/10.1111/j.1528-1157.1997.tb01484.x