Artículo

França, L.R.; Suescun, M.O.; Miranda, J.R.; Giovambattista, A.; Perello, M.; Spinedi, E.; Calandra, R.S. "Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages" (2006) Endocrinology. 147(3):1556-1563
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Abstract:

There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. Plasma levels of leptin, LH, FSH, prolactin, testosterone (T), corticosterone, and free T4 (FT4) were measured. MSG rats displayed elevated circulating levels of corticosterone and hyperadiposity/ hyperleptinemia, regardless of the age examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal MSG rats revealed a significant (P < 0.05) reduction in testis weight and the number of Sertoli (SC) and Leydig cells per testis. Leptin plasma levels were severalfold higher (2.41 vs. 8.07; P < 0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T, and FT4 levels significantly decreased (P < 0.05). Taken together, these data indicate that testis development, as well as SC and Leydig cell proliferation, were disturbed in prepubertal MSG rats. Adult MSG rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04; P < 0.05) and lower (P < 0.05) LH and FSH plasma levels. However, T and FT4 plasma levels were normal, and no apparent alterations were observed in testis structure of MSG rats. Only the number of SCs per testis was significantly (P < 0.05) reduced in the adult MSG rats. In conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably responsible for the reproductive axis damages in MSG animals, it remains to be investigated whether this condition is the main factor for hypothalamus-pituitary-gonadal axis dysfunction in MSG rats. Copyright © 2006 by The Endocrine Society.

Registro:

Documento: Artículo
Título:Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
Autor:França, L.R.; Suescun, M.O.; Miranda, J.R.; Giovambattista, A.; Perello, M.; Spinedi, E.; Calandra, R.S.
Filiación:Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG 31270-901, Brazil
Laboratory of Reproductive Endocrinology, Instituto Multidiscipliario de Biologia Celular, Universidad Nacional de la Plata, La Plata 1900, Argentina
Neuroendocrine Unit, Instituto Multidiscipliario de Biologia Celular, Universidad Nacional de la Plata, La Plata 1900, Argentina
School of Exact Sciences, Universidad Nacional de la Plata, La Plata 1900, Argentina
Instituto de Biologia Y Medicina Experimental, Buenos Aires 1428, Argentina
Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil
Palabras clave:corticosterone; follitropin; glutamate sodium; leptin; luteinizing hormone; testosterone; animal experiment; animal model; animal tissue; article; body weight; cell proliferation; corticosterone blood level; data analysis; female; follitropin blood level; free thyroxine index; genetics; hormone blood level; hyperleptinemia; hypothalamus hypophysis system; Leydig cell; luteinizing hormone blood level; male; measurement; newborn; nonhuman; obesity; phenotype; prepuberty; priority journal; prolactin blood level; rat; reproduction; Sertoli cell; testis; testis function; testis weight; testosterone blood level; Adipose Tissue; Animals; Animals, Newborn; Cell Nucleus; Cell Proliferation; Corticosterone; Female; Follicle Stimulating Hormone; Leptin; Leydig Cells; Male; Mice; Phenotype; Prolactin; Rats; Rats, Sprague-Dawley; Seminiferous Tubules; Sertoli Cells; Testis; Testosterone; Thyroxine; Time Factors
Año:2006
Volumen:147
Número:3
Página de inicio:1556
Página de fin:1563
DOI: http://dx.doi.org/10.1210/en.2005-0640
Título revista:Endocrinology
Título revista abreviado:Endocrinology
ISSN:00137227
CODEN:ENDOA
CAS:corticosterone, 50-22-6; follitropin, 9002-68-0; glutamate sodium, 142-47-2, 16177-21-2, 16690-92-9; luteinizing hormone, 39341-83-8, 9002-67-9; testosterone, 58-22-0; Corticosterone, 50-22-6; Follicle Stimulating Hormone, 9002-68-0; Leptin; Prolactin, 9002-62-4; Testosterone, 58-22-0; Thyroxine, 7488-70-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v147_n3_p1556_Franca

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Citas:

---------- APA ----------
França, L.R., Suescun, M.O., Miranda, J.R., Giovambattista, A., Perello, M., Spinedi, E. & Calandra, R.S. (2006) . Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages. Endocrinology, 147(3), 1556-1563.
http://dx.doi.org/10.1210/en.2005-0640
---------- CHICAGO ----------
França, L.R., Suescun, M.O., Miranda, J.R., Giovambattista, A., Perello, M., Spinedi, E., et al. "Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages" . Endocrinology 147, no. 3 (2006) : 1556-1563.
http://dx.doi.org/10.1210/en.2005-0640
---------- MLA ----------
França, L.R., Suescun, M.O., Miranda, J.R., Giovambattista, A., Perello, M., Spinedi, E., et al. "Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages" . Endocrinology, vol. 147, no. 3, 2006, pp. 1556-1563.
http://dx.doi.org/10.1210/en.2005-0640
---------- VANCOUVER ----------
França, L.R., Suescun, M.O., Miranda, J.R., Giovambattista, A., Perello, M., Spinedi, E., et al. Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages. Endocrinology. 2006;147(3):1556-1563.
http://dx.doi.org/10.1210/en.2005-0640