Artículo

Castro, C.P.; Peñalva, R.; Pereda, M.P.; Renner, U.; Reul, J.M.H.M.; Stalla, G.K.; Holsboer, F.; Arzt, E. "Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response" (1999) Endocrinology. 140(2):690-697
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Abstract:

Functional interaction between the immune and neuroendocrine systems is mediated by humoral mediators, neurotransmitters, and cytokines, including TRH and PRL. We examined the role of neuroendocrine changes, particularly TRH and PRL, during the T cell-dependent immune response. After immunization of rats with sheep red blood cells (SRBC, a T cell-dependent antigen), an increase of hypothalamic TRH messenger RNA (mRNA) was observed at 4-24 h post immunization, in contrast to the decrease observed after treatment with lipopolysaccharide (LPS). During the above period, with SRBC, there was an increase in pituitary TRH receptor mRNA and plasma PRL levels but no changes in TSH and GH. Also, in contrast to the early corticosterone peak induced by LPS, the activation of the hypothalamic-pituitary-adrenocortical suppressive response appears in a late phase, 5-7 days after SRBC. Intracerebroventricular injection of antisense oligonucleotide complementary to rat TRH mRNA in conscious freely-moving rats immunized with SRBC resulted in a significant inhibition of specific antibody production and a concomitant inability to produce the peak in plasma PRL levels. These studies demonstrate, for the first time, that the T cell-dependent immune response is critically dependent on the early activation of TRH and PRL and that the neuroendocrine changes occurring during it are profoundly different from those occurring during the T cell-independent and inflammatory responses (LPS model).

Registro:

Documento: Artículo
Título:Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response
Autor:Castro, C.P.; Peñalva, R.; Pereda, M.P.; Renner, U.; Reul, J.M.H.M.; Stalla, G.K.; Holsboer, F.; Arzt, E.
Filiación:Max-Planck Institute of Psychiatry, Clinical Institute, Kraepelinstr, 2-10, 80804 Munich, Germany
Lab. de Fisiologia y Biologia Molec., Department de Bioloǵa, Fac. Ciencias Exactas y Naturales, Ciudad Universitaria-Pabellon II, 1428 Buenos Aires, Argentina
Palabras clave:prolactin; protirelin; animal tissue; article; cellular immunity; immune response; male; nonhuman; priority journal; prolactin release; rat; sheep; T lymphocyte; thyrotropin release
Año:1999
Volumen:140
Número:2
Página de inicio:690
Página de fin:697
DOI: http://dx.doi.org/10.1210/endo.140.2.6482
Handle:http://hdl.handle.net/20.500.12110/paper_00137227_v140_n2_p690_Castro
Título revista:Endocrinology
Título revista abreviado:Endocrinology
ISSN:00137227
CODEN:ENDOA
CAS:prolactin, 12585-34-1, 50647-00-2, 9002-62-4; protirelin, 24305-27-9
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00137227_v140_n2_p690_Castro.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v140_n2_p690_Castro

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Citas:

---------- APA ----------
Castro, C.P., Peñalva, R., Pereda, M.P., Renner, U., Reul, J.M.H.M., Stalla, G.K., Holsboer, F.,..., Arzt, E. (1999) . Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response. Endocrinology, 140(2), 690-697.
http://dx.doi.org/10.1210/endo.140.2.6482
---------- CHICAGO ----------
Castro, C.P., Peñalva, R., Pereda, M.P., Renner, U., Reul, J.M.H.M., Stalla, G.K., et al. "Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response" . Endocrinology 140, no. 2 (1999) : 690-697.
http://dx.doi.org/10.1210/endo.140.2.6482
---------- MLA ----------
Castro, C.P., Peñalva, R., Pereda, M.P., Renner, U., Reul, J.M.H.M., Stalla, G.K., et al. "Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response" . Endocrinology, vol. 140, no. 2, 1999, pp. 690-697.
http://dx.doi.org/10.1210/endo.140.2.6482
---------- VANCOUVER ----------
Castro, C.P., Peñalva, R., Pereda, M.P., Renner, U., Reul, J.M.H.M., Stalla, G.K., et al. Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response. Endocrinology. 1999;140(2):690-697.
http://dx.doi.org/10.1210/endo.140.2.6482