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Abstract:

p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last procedure was inhibited by both tyramine and dopamine; tyramine produced the same effect as dopamine at a dose 5 times greater. When PRL levels were increased by pretreatment with a-methyl-p-tyrosine or halperidol, once again both tyramine and dopamine lowered PRL titers. The hypoprolactinemic effect of p-tyramine was also observed in median eminence-lesioned animals, suggesting a pituitary site of action. These results show that low amounts of tyramine, a naturally occurring amine, can inhibit in vivo increases in PRL levels achieved physiologically or pharmacologically. © 1985 by The Endocrine Society.

Registro:

Documento: Artículo
Título:P-tyramine, a natural amine, inhibits prolactin release in vivo
Autor:Bec-Villalobos, D.; de mengido, I.M.; Libertun, C.
Filiación:Institute de Biologia y Medicina Experimental, Buenos Aires, 1428, Argentina
Palabras clave:dopamine; haloperidol; metirosine; tyramine; animal experiment; brain injury; central nervous system; drug efficacy; endocrine system; hypophysis; male genital system; median eminence; nonhuman; orchiectomy; priority journal; prolactin release; rat; stress; alpha-Methyltyrosine; Animal; Castration; Haloperidol; Male; Median Eminence; Methyltyrosines; Prolactin; Rats; Rats, Inbred Strains; Stress; Support, Non-U.S. Gov't; Tyramine
Año:1985
Volumen:116
Número:5
Página de inicio:2044
Página de fin:2048
DOI: http://dx.doi.org/10.1210/endo-116-5-2044
Título revista:Endocrinology
Título revista abreviado:Endocrinology
ISSN:00137227
CAS:dopamine, 51-61-6, 62-31-7; haloperidol, 52-86-8; metirosine, 672-87-7; tyramine, 51-67-2, 60-19-5; alpha-Methyltyrosine, 658-48-0; Haloperidol, 52-86-8; Methyltyrosines; Prolactin, 9002-62-4; Tyramine, 51-67-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v116_n5_p2044_BecVillalobos

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Citas:

---------- APA ----------
Bec-Villalobos, D., de mengido, I.M. & Libertun, C. (1985) . P-tyramine, a natural amine, inhibits prolactin release in vivo. Endocrinology, 116(5), 2044-2048.
http://dx.doi.org/10.1210/endo-116-5-2044
---------- CHICAGO ----------
Bec-Villalobos, D., de mengido, I.M., Libertun, C. "P-tyramine, a natural amine, inhibits prolactin release in vivo" . Endocrinology 116, no. 5 (1985) : 2044-2048.
http://dx.doi.org/10.1210/endo-116-5-2044
---------- MLA ----------
Bec-Villalobos, D., de mengido, I.M., Libertun, C. "P-tyramine, a natural amine, inhibits prolactin release in vivo" . Endocrinology, vol. 116, no. 5, 1985, pp. 2044-2048.
http://dx.doi.org/10.1210/endo-116-5-2044
---------- VANCOUVER ----------
Bec-Villalobos, D., de mengido, I.M., Libertun, C. P-tyramine, a natural amine, inhibits prolactin release in vivo. Endocrinology. 1985;116(5):2044-2048.
http://dx.doi.org/10.1210/endo-116-5-2044