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Abstract:

Pharmacological manipulation of Hi and H2 histamine receptors clearly indicates their participation in control of anterior pituitary secretion by the brain. Of particular interest is the PRL-releasing effect of H2 histamine receptor blocking agents like metiamide and cimetidine. The aim of the present study was to determine whether serotoninergic pathways, which exert a well known releasing effect on PRL secretion, were involved in the PRL-releasing action of cimetidine.As our first approach, the PRL-releasing effect of cimetidine was determined in developing male and female rats. Cimetidine failed to increase PRL in rats of 1 and 4 days of age. From 12 days onwards, the drug was able to cause a PRL increment in both sexes. There was a significant release of PRL at 20 and 28 days of age, and the response was greater in male than in female rats. The ontogeny of the cimetidine action, both in timing and sex differences, showed a close similarity with the development of the serotoninergic control of PRL secretion, and it was in clear contrast with the maturation of other controlling mechanisms, dopaminergic and TRH.In a second set of experiments, adult male rats were used. Methysergide, a serotonin receptor blocker, used in a dose and given by a route so that it did not modify the basal level of PRL, was able to completely prevent the PRL release evoked by cimetidine. Administration of p-chlorophenylalanine, a drug which reduces serotonin synthesis, was followed by a significant decline in the indole content of a portion of the brain which included the brain stem, the hypothalamus, and the preopticsuprachiasmatic area; and by a blockade of the PRL-releasing effect of cimetidine. Treatment of adult male rats with cimetidine, methysergide, or serotonin did not modify serum LH.It is concluded that a major serotoninergic input is involved in the PRL-releasing effect of cimetidine. © 1983 by The Endocrine Society.

Registro:

Documento: Artículo
Título:Serotoninergic involvement in the cimetidine-induced prolactin release
Autor:Becu, D.; Libertun, C.
Filiación:Laboratorio de Neuroendocrinología, Institute de Biología y Medicina Experimental, Buenos Aires, 1428, Argentina
Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina
Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina
Palabras clave:cimetidine; fenclonine; histamine receptor; methysergide; adenohypophysis; animal experiment; endocrine system; intraperitoneal drug administration; nonhuman; prolactin release; rat; serotoninergic system; Aging; Animal; Cimetidine; Female; Fenclonine; Luteinizing Hormone; Male; Methysergide; Prolactin; Rats; Rats, Inbred Strains; Serotonin; Sex Factors; Support, Non-U.S. Gov't
Año:1983
Volumen:113
Número:6
Página de inicio:1980
Página de fin:1984
DOI: http://dx.doi.org/10.1210/endo-113-6-1980
Título revista:Endocrinology
Título revista abreviado:Endocrinology
ISSN:00137227
CAS:cimetidine, 51481-61-9, 70059-30-2; fenclonine, 1991-78-2, 7424-00-2; methysergide, 16509-15-2, 361-37-5, 62288-72-6; Cimetidine, 51481-61-9; Fenclonine, 7424-00-2; Luteinizing Hormone, 9002-67-9; Methysergide, 361-37-5; Prolactin, 9002-62-4; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v113_n6_p1980_Becu

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Citas:

---------- APA ----------
Becu, D. & Libertun, C. (1983) . Serotoninergic involvement in the cimetidine-induced prolactin release. Endocrinology, 113(6), 1980-1984.
http://dx.doi.org/10.1210/endo-113-6-1980
---------- CHICAGO ----------
Becu, D., Libertun, C. "Serotoninergic involvement in the cimetidine-induced prolactin release" . Endocrinology 113, no. 6 (1983) : 1980-1984.
http://dx.doi.org/10.1210/endo-113-6-1980
---------- MLA ----------
Becu, D., Libertun, C. "Serotoninergic involvement in the cimetidine-induced prolactin release" . Endocrinology, vol. 113, no. 6, 1983, pp. 1980-1984.
http://dx.doi.org/10.1210/endo-113-6-1980
---------- VANCOUVER ----------
Becu, D., Libertun, C. Serotoninergic involvement in the cimetidine-induced prolactin release. Endocrinology. 1983;113(6):1980-1984.
http://dx.doi.org/10.1210/endo-113-6-1980