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Abstract:

The hypothalamus may control hormone receptors in the anterior pituitary either by a direct trophic effect or indirectly by regulation of serum pituitary hormone levels. Rats whose medial basal hypothalamus had been destroyed in order to suppress neural control of the gland showed a reduction in [ 3 H]estradiol binding in the anterior pituitary and high serum PRL levels; both changes were reversed by treatment of the lesioned rats with daily injections of bromocriptine, a dopamine agonist. In nonlesioned animals, the same treatment did not modify significantly those parameters.In another hyperprolactinemic model (rats with anterior pituitaries transplanted under the kidney capsule), [:fH]estradiol binding by the in situ pituitaries of the host rats was similar to that in the nongrafted controls.These results suggest that changes due to median eminence lesion are reversible and that bromocriptine is able to act as a substitutive therapy which restores binding of estradiol in glands whose receptors have been decreased by the effect of the lesion. High PRL levels due to pituitary transplant do not account for the observed changes in the pituitary estradiol binding. © 1981 by The Endocrine Society.

Registro:

Documento: Artículo
Título:Effects of bromocriptine on [ 3 H]Estradiol binding in cytosol of anterior pituitary
Autor:Nicola, A.F.D.; Weisenberg, L.S.; Arakelian, M.C.; Libertun, C.
Filiación:Laboratorios de Esteroides y de Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina
Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina
Palabras clave:bromocriptine; estrogen receptor; prolactin; radioisotope; sex hormone binding protein; bromocriptine; estradiol; estrogen receptor; tritium; adenohypophysis; animal experiment; brain injury; cytosol; drug binding; endocrine system; estradiol h 3; hypophysis; median eminence; prolactin blood level; rat; adenohypophysis; animal; article; cytosol; drug effect; female; kinetics; metabolism; Animal; Bromocriptine; Cytosol; Estradiol; Female; Kinetics; Pituitary Gland, Anterior; Rats; Receptors, Estrogen; Support, Non-U.S. Gov't; Tritium
Año:1981
Volumen:109
Número:1
Página de inicio:83
Página de fin:86
DOI: http://dx.doi.org/10.1210/endo-109-1-83
Título revista:Endocrinology
Título revista abreviado:Endocrinology
ISSN:00137227
CAS:bromocriptine, 25614-03-3; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; estradiol, 50-28-2; tritium, 10028-17-8; Bromocriptine, 25614-03-3; Estradiol, 50-28-2; Receptors, Estrogen; Tritium, 10028-17-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v109_n1_p83_Nicola

Referencias:

  • Weisenberg, L., De Nicola, A.F., Arakalian, M.C., Libertun, C., Effect of median eminence lesions on (*H) estradiol binding in the anterior pituitary and hypothalamus (1979) Endocrinology, 105, p. 1152
  • Libertun, C., Larrea, G.A., Vacas, M.I., Cardinali, D.P., Dihydroer-gocryptin binding in anterior pituitary and prolactin secretion: Further evidence of brain regulation of adenohypophysial receptors (1980) Endocrinology, 107, p. 1905
  • Bishop, W.L., Fawcett, C.P., Krulich, L., Mc Cann, S.M., Acute and chronic effects of hypothalamic lesions on the release of FSH, LH and prolactin in intact and castrated rats (1972) Endocrinology, 91, p. 643
  • Libertun, C., Kaplan, S.E., De Nicola, A.F., Progesterone negative feedback on prolactin secretion: Importance of the brain control and of estradiol (1979) Neuroendocrinology, 28, p. 64
  • Everett, J.W., Luteotrophic function of autografts of the rat hypophysis (1954) Endocrinology, 54, p. 685
  • Ginsburg, M., Greenstein, B.D., Maclusky, N.J., Morris, I.D., Thomas, P.J., An improved method for the study of high-affinity steroid binding: Oestradiol binding in brain and pituitary (1974) Steroids, 23, p. 773
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurent with the Folin phenol reagent (1951) J Biol Chem, 193, p. 265
  • Arakelian, M.C., Libertun, C., Hi and H2 receptor participation in the brain control of prolactin secretion in lactating rats (1977) Endocrinology, 100, p. 890
  • Meites, J., Clemens, J.A., Hypothalamic control of prolactin secretion (1972) Vitam Horm, 30, p. 166
  • Macleod, R.M., Regulation of prolactin secretion (1976) Frontiers in Neuroendocrinology, 4, p. 169. , Martini L, Ganong WF (eds),. Raven Press, New York
  • Fuxe, K., Fredholm, B.B., Ogren, S.E., Agnati, L.F., Hôkfelt, T., Gustafsson, J.A., Pharmacological and biochemical evidence for the dopamine agonistic effect of bromocriptine (1978) Acta Endocrinol (Copenh), 88, p. 27
  • Mc Cann, S.M., Dhariwal, A., Hypothalamic releasing factors and the neurovascular link between the brain and the anterior pituitary (1966) Neuroendocrinology, p. 261. , Martini F, Ganong WF (eds),. Academic Press, New York
  • Zanini, A., Giannattasio, G., De Camili, P., Panerai, A.E., Müller, E.E., Meldolesi, J., Studies on rat pituitary homografts. I. In vitro biosynthesis and release of growth hormone and prolactin (1979) Endocrinology, 194, p. 226
  • Chen, C.L., Amenomori, Y., Lu, K.H., Voogt, J.L., Meites, J., Serum prolactin levels in rats with pituitary transplants or hypothalamic lesions (1970) Neuroendocrinology, 6, p. 220

Citas:

---------- APA ----------
Nicola, A.F.D., Weisenberg, L.S., Arakelian, M.C. & Libertun, C. (1981) . Effects of bromocriptine on [ 3 H]Estradiol binding in cytosol of anterior pituitary. Endocrinology, 109(1), 83-86.
http://dx.doi.org/10.1210/endo-109-1-83
---------- CHICAGO ----------
Nicola, A.F.D., Weisenberg, L.S., Arakelian, M.C., Libertun, C. "Effects of bromocriptine on [ 3 H]Estradiol binding in cytosol of anterior pituitary" . Endocrinology 109, no. 1 (1981) : 83-86.
http://dx.doi.org/10.1210/endo-109-1-83
---------- MLA ----------
Nicola, A.F.D., Weisenberg, L.S., Arakelian, M.C., Libertun, C. "Effects of bromocriptine on [ 3 H]Estradiol binding in cytosol of anterior pituitary" . Endocrinology, vol. 109, no. 1, 1981, pp. 83-86.
http://dx.doi.org/10.1210/endo-109-1-83
---------- VANCOUVER ----------
Nicola, A.F.D., Weisenberg, L.S., Arakelian, M.C., Libertun, C. Effects of bromocriptine on [ 3 H]Estradiol binding in cytosol of anterior pituitary. Endocrinology. 1981;109(1):83-86.
http://dx.doi.org/10.1210/endo-109-1-83