Artículo
Abstract:
Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation. © 2015 Elsevier Ltd.
Registro:
| Documento: | Artículo |
| Título: | Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device |
| Autor: | Luján, E.; Schinca, H.; Olaiz, N.; Urquiza, S.; Molina, F.V.; Turjanski, P.; Marshall, G. |
| Filiación: | Laboratorio de Sistemas Complejos, Departamento de Computación, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Instituto de Física del Plasma, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Instituto de Química Física de los Materiales, Medio Ambiente y Energía, Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Grupo de Ingeniería Asistida por Computadora, Facultad de Ingeniería, Universidad Nacional de Mar del Plata, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina |
| Palabras clave: | Electrochemical treatment; Electrolytic ablation; in silico models; in vitro models; pH front tracking; Tumors; Ablation; Electrodes; Probes; Tissue; Dose response relationships; Electrochemical reactions; Electrochemical treatments; Front tracking; In-silico models; In-vitro models; Minimally invasive treatments; Non-linear relationships; Tumors |
| Año: | 2015 |
| Volumen: | 186 |
| Página de inicio: | 494 |
| Página de fin: | 503 |
| DOI: | http://dx.doi.org/10.1016/j.electacta.2015.10.147 |
| Título revista: | Electrochimica Acta |
| Título revista abreviado: | Electrochim Acta |
| ISSN: | 00134686 |
| CODEN: | ELCAA |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00134686_v186_n_p494_Lujan |
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Citas:
---------- APA ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P. & Marshall, G. (2015) . Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device. Electrochimica Acta, 186, 494-503.http://dx.doi.org/10.1016/j.electacta.2015.10.147
---------- CHICAGO ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. "Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device" . Electrochimica Acta 186 (2015) : 494-503.http://dx.doi.org/10.1016/j.electacta.2015.10.147
---------- MLA ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. "Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device" . Electrochimica Acta, vol. 186, 2015, pp. 494-503.http://dx.doi.org/10.1016/j.electacta.2015.10.147
---------- VANCOUVER ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device. Electrochim Acta. 2015;186:494-503.http://dx.doi.org/10.1016/j.electacta.2015.10.147
