Abstract:
Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation. © 2015 Elsevier Ltd.
Registro:
Documento: |
Artículo
|
Título: | Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device |
Autor: | Luján, E.; Schinca, H.; Olaiz, N.; Urquiza, S.; Molina, F.V.; Turjanski, P.; Marshall, G. |
Filiación: | Laboratorio de Sistemas Complejos, Departamento de Computación, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Instituto de Física del Plasma, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Instituto de Química Física de los Materiales, Medio Ambiente y Energía, Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Grupo de Ingeniería Asistida por Computadora, Facultad de Ingeniería, Universidad Nacional de Mar del Plata, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
|
Palabras clave: | Electrochemical treatment; Electrolytic ablation; in silico models; in vitro models; pH front tracking; Tumors; Ablation; Electrodes; Probes; Tissue; Dose response relationships; Electrochemical reactions; Electrochemical treatments; Front tracking; In-silico models; In-vitro models; Minimally invasive treatments; Non-linear relationships; Tumors |
Año: | 2015
|
Volumen: | 186
|
Página de inicio: | 494
|
Página de fin: | 503
|
DOI: |
http://dx.doi.org/10.1016/j.electacta.2015.10.147 |
Título revista: | Electrochimica Acta
|
Título revista abreviado: | Electrochim Acta
|
ISSN: | 00134686
|
CODEN: | ELCAA
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00134686_v186_n_p494_Lujan |
Referencias:
- Nordenström, B., (1983) Biologically Closed Electrical Circuits: Clinical, Experimental and Theoretical Evidence for an Additional Circulatory System, , Nordic Medical Publications Stockholm, Sweeden
- Nordenström, B., (1989) Am J Clin Oncol: Cancer Clinical Trials, 12, p. 530
- Xin, Y., (1994) Eur J Surg Suppl, 574, p. 25
- Xin, Y., Liu, D., Meng, X., (2001) Zhongguo Zhong Xi Yi Jie He Za Zhi, 21, p. 174
- Miklavčič, D., Serša, G., Novakovič, S., Rebersek, S., (1990) J Bioelectricity, 9, p. 133
- Miklavčič, D., Serša, G., Kryžanowski, M., Novakovič, S., Bobanovič, F., Golouh, R., Vodovnik, L., (1993) Bioelectrochem Bioenerg, 30, p. 209
- Serša, G., Miklavčič, D., (1993) Regional Cancer Treatment, 6, p. 31
- Miklavčič, D., Fajgelj, A., Serša, G., (1994) Bioelectrochem Bioenerg, 35, p. 93
- Mir, L., (2006) European Journal of Cancer Supp, 4, p. 38
- Mali, B., Jarm, T., Snoj, M., Sersa, G., Miklavcic, D., (2013) European Journal of Surgical Oncology, 39, p. 4
- Phillips, M., Raju, N., Rubinsky, L., Rubinsky, B., (2015) TECHNOLOGY, 3, p. 1
- Nilsson, E., Berendson, J., Fontes, E., (2000) Journal of Applied Electrochemistry, 30, p. 1321
- Nilsson, E., Fontes, E., (2001) Bioelectrochemisty, 53, p. 213
- Nilsson, E., Von Euler, H., Berendson, J., Thörne, A., Wersäll, P., Näslund, I., Lagerstedt, A., Olsson, J., (2000) Bioelectrochemistry, 51, p. 1
- Nilsson, E., Berendson, J., Fontes, E., (1999) J Electroanal Chem, 460, p. 88
- Nilsson, E., Berendson, J., Fontes, E., (1998) Bioelectrochem Bioenerg, 47, p. 11
- Colombo, L., González, G., Marshall, G., Molina, F., Soba, A., Suárez, C., Turjanski, P., (2007) Bioelectrochemistry, 71, p. 223
- Turjanski, P., Olaiz, N., Abou-Adal, P., Suárez, C., Risk, M., Marshall, G., (2009) Electrochimica Acta, 54, p. 6199
- Olaiz, N., Maglietti, F., Suárez, C., Molina, F., Miklavcicc, D., Mir, L., Marshall, G., (2010) Electrochimica Acta, 55, p. 6010
- Nilsson, E., (2000) Modelling of the electrochemical treatment of tumours, , Ph.D. thesis, Department of Chemical Engineering and Technology, Applied Electrochemistry, Royal Institute of Technology
- Xin, Y.-L., Xue, F.-Z., Ge, B.-S., Zhao, F.-R., Shi, B., Zhang, W., (1997) Bioelectromagnetics, 18, p. 8
- Newman, J., Thomas-Alyea, K., (2004) Electrochemical Systems, , 3rd Edition John Wiley & Sons, Inc Hoboken, New Jersey
- West, J., (1985) Physiological Basis of Medical Practice, , 11th Edition Lippincott, William & Wilkins Baltimore
- Damjanovic, A., Birss, V., Boudreaux, D., (1991) Journal of The Electrochemical Society, 138, p. 2549
- Bard, A., (1973) Encyclopedia of Electrochemistry of the Elements, , Marcel Dekker New York
- Moore, W., (1983) Basic Physical Chemistry, , Prentice-Hall Int Ed London
Citas:
---------- APA ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P. & Marshall, G.
(2015)
. Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device. Electrochimica Acta, 186, 494-503.
http://dx.doi.org/10.1016/j.electacta.2015.10.147---------- CHICAGO ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al.
"Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device"
. Electrochimica Acta 186
(2015) : 494-503.
http://dx.doi.org/10.1016/j.electacta.2015.10.147---------- MLA ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al.
"Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device"
. Electrochimica Acta, vol. 186, 2015, pp. 494-503.
http://dx.doi.org/10.1016/j.electacta.2015.10.147---------- VANCOUVER ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device. Electrochim Acta. 2015;186:494-503.
http://dx.doi.org/10.1016/j.electacta.2015.10.147