Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The present study was aimed at determining the generation of 'prostacyclin (PGI2)-like-material' in coronary arteries from normal and diabetic (pancreatectomized) dogs as well as the contractile responses to prostacyclin of preparations from normal, diabetic and insulin-treated diabetic animals. PGI2 produced a dose-dependent relaxation of coronary arteries from normal dogs. In contrast, those from diabetic animals were not relaxed; indeed, at low concentrations PGI2 failed to evoke any effect but at higher ones it induced a distinct contraction. In arteries from diabetic animals treated with insulin, PGI2 induced a biphasic contractile effect, which lay between that of normal controls and untreated diabetics. In addition the basal generation of 'PGI2-like-material' by coronary arteries was significantly higher in the diabetic (141±0.2 pg/mg, mean±SEM) than in normal dogs (59±0.2 pg/mg). The present experiments demonstrate that the generation of 'PGI2-like-substance' is significantly increased in coronary arteries from diabetic dogs, but the same vessels are unable to respond to added authentic PGI2 with relaxation; on the contrary they react with a distinct positive contractile response. © 1982 Springer-Verlag.

Registro:

Documento: Artículo
Título:Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs
Autor:Sterin-Borda, L.; Borda, E.S.; Gimeno, M.F.; Lazzari, M.A.; del Castillo, E.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales, Consejo Nacional de Investigaciones Cientificas y Tecnicas and Instituto de Investigaciones, Academia Nacional de Medicina, Buenos Aires, Argentina
Palabras clave:coronary constriction; coronary relaxation; diabetes; Isolated coronary arteries; pancreatectomized dogs; PGI2 generation; prostacyclin; haloperidol; insulin; phentolamine; phentolamine mesylate; prostacyclin; animal experiment; coronary artery; diabetes mellitus; dog; endocrine system; heart; in vitro study; pancreas; pancreas resection; peripheral vascular system; smooth muscle contractility; vascular smooth muscle; Animals; Coronary Vessels; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Pancreatectomy; Prostaglandins; Vasoconstriction
Año:1982
Volumen:22
Número:1
Página de inicio:56
Página de fin:59
DOI: http://dx.doi.org/10.1007/BF00253871
Título revista:Diabetologia
Título revista abreviado:Diabetologia
ISSN:0012186X
CODEN:DBTGA
CAS:haloperidol, 52-86-8; insulin, 9004-10-8; phentolamine, 50-60-2, 73-05-2; phentolamine mesylate, 65-28-1; prostacyclin, 35121-78-9, 61849-14-7; Epoprostenol, 35121-78-9; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0012186X_v22_n1_p56_SterinBorda

Referencias:

  • Moncada, S., Higgs, E.A., Vane, J.R., Human arterial and venous tissues generate prostacyclin (prostaglandin X), a potent inhibitor of platelet aggregation (1977) Lancet, 1, pp. 18-20
  • Dusting, G.F., Moncada, S., Vane, J.R., Prostacyclin is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid (1977) Prostaglandins, 13, pp. 3-15
  • Schrör, K., Moncada, S., Ubatuba, F.B., Vane, J.R., Formation of prostacyclin causes decrease in coronary vascular resistance during application of arachidonic acid in the rabbit isolated heart (1977) Naunyn Schmiedeberg's Arch Pharmacol, 297, p. R31
  • Schrör, K., Moncada, S., Ubatuba, F.B., Vane, J.R., Transformation of arachidonic acid and prostaglandin endoperoxide by the guinea pig heart. Formation of RCS and prostacyclin (1978) European Journal of Pharmacology, 47, pp. 103-114
  • Moncada, S., Gryglewsky, R., Bunting, S., Vane, J.R., An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation (1976) Nature, 263, pp. 663-665
  • Pomerantz, K., Sintetos, A., Ramwell, P., The effect of prostacyclin on the human umbilical artery (1978) Prostaglandins, 15, pp. 1035-1044
  • Chapeau, C.E., White, R.P., Effects of prostacyclin on the canine isolated basilar artery (1979) Prostaglandins, 17, pp. 573-580
  • Schrör, K., Rösen, P., Prostacyclin (PGI<inf>2</inf>) decreases the cyclic AMP level in coronary arteries (1979) Naunyn Schmiedeberg's Arch Pharmacol, 306, pp. 101-103
  • Ogletree, M.L., Smith, B.J., Lefer, A.M., Actions of prostaglandins on isolated perfused cat coronary arteries (1978) Am J Physiol, 235, pp. 400-406
  • Bern, M.B., Platelet functions in diabetes mellitus (1978) Diabetes, 27, pp. 342-352
  • Colwell, J.A., Chambers, A., Laimins, M., Increased platelet aggregation in early diabetes (1975) Diabetes, 24, pp. 684-687
  • Owen, M.P., Carrier, G.O., Alteration in vascular smooth muscle sensitivity to vasoconstrictor agents by streptozotocin induced diabetes (1979) Proc West Pharmacol Soc, 22, pp. 363-366
  • del Castillo, E.J., Galli, M.E., Roldán, A., Rietti, C.T., Houssay, B.A., Decrease in Ketonemia due to infusion of lipids in pancreatectomized dogs (1965) Diabetes, 14, pp. 33-35
  • Borda, L., Schuchleib, R., Henry, P., Effect of potassium on isolated canine coronary arteries (1977) Circ Res, 41, pp. 778-786
  • Sterin-Bora, L., Gimeno, A.L., Gimeno, M.F., Frequencyforce relationship on isolated rat and guinea pig atria. Effect of cholinergic and adrenergic receptor antagonists (1974) Proc Soc Exp Biol Med, 145, pp. 1151-1157
  • Gimeno, M.F., Sterin-Borda, L., Borda, E.S., Lazzari, M.A., Gimeno, A.L., Human plasma transforms prostacyclin (PGI<inf>2</inf>) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries (1980) Prostaglandins, 19, pp. 907-916
  • Borda, E.S., Lazzari, M.A., Gimeno, M.F., Gimeno, A.L., Human platelet rich plasma and human serum protects from inactivation the antiaggregatory capacity of prostacyclin-like material (PGI<inf>2</inf>) produced by the rat stomach fundus (1980) Prostaglandins, 19, pp. 899-905
  • Dusting, G.J., Chapple, D.J., Hughes, R., Moncada, S., Vane, J.R., Prostacyclin (PGI<inf>2</inf>) induces coronary vasodilatation in anaesthetized dogs (1978) Cardiovasc Res, 12, pp. 720-730
  • Dusting, G.J., Moncada, S., Vane, J.R., Recirculation of prostacyclin (PGI<inf>2</inf>) in the dog (1978) Br J Pharmacol, 64, pp. 315-320
  • Fitzpatrick, T.M., Alter, I., Corey, E.J., Ramwell, P.W., Rose, J.C., Kot, P.A., Cardiovascular responses to PGI<inf>2</inf> (prostacyclin) in the dog (1978) Circulation Res, 42, pp. 192-194
  • Borda, L.S., Canga, L., Gimeno, M.F., Gimeno, A.L., Adrenergic mechanism subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria (1979) Experientia, 35, pp. 529-531
  • Borda, E.S., Agostini, M.C., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L., Spontaneous contractile activity of isolated ovarian human vein. Influence of prostacyclin (PGI<inf>2</inf>) (1979) Prostaglandins, 18, pp. 829-935
  • Herman, A.G., Verbeurens, T.J., Moncada, S., Vane, J.R., Vanhoutte, P.M., Effect of prostacyclin on myogenic activity and adrenergic neuroeffector interaction in isolated canine veins (1978) Arch Int Pharmacodyn Ther, 232, pp. 340-341
  • Rösen, P., Schrör, K., Increased prostacyclin release from perfused hearts of acutely diabetic rats (1980) Diabetologia, 18, pp. 391-394
  • Harrison, H.E., Reece, A.H., Johnson, M., Decreased vascular prostacyclin in experimental diabetes (1978) Life Sci, 33, pp. 351-356
  • Silberbauer, K., Schernthaner, G., Sinzinger, H., Piza-Katzer, H., Decreased vascular prostacyclin in juvenile onset diabetics (1979) N Engl J Med, 300, pp. 366-367

Citas:

---------- APA ----------
Sterin-Borda, L., Borda, E.S., Gimeno, M.F., Lazzari, M.A., del Castillo, E. & Gimeno, A.L. (1982) . Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs. Diabetologia, 22(1), 56-59.
http://dx.doi.org/10.1007/BF00253871
---------- CHICAGO ----------
Sterin-Borda, L., Borda, E.S., Gimeno, M.F., Lazzari, M.A., del Castillo, E., Gimeno, A.L. "Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs" . Diabetologia 22, no. 1 (1982) : 56-59.
http://dx.doi.org/10.1007/BF00253871
---------- MLA ----------
Sterin-Borda, L., Borda, E.S., Gimeno, M.F., Lazzari, M.A., del Castillo, E., Gimeno, A.L. "Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs" . Diabetologia, vol. 22, no. 1, 1982, pp. 56-59.
http://dx.doi.org/10.1007/BF00253871
---------- VANCOUVER ----------
Sterin-Borda, L., Borda, E.S., Gimeno, M.F., Lazzari, M.A., del Castillo, E., Gimeno, A.L. Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs. Diabetologia. 1982;22(1):56-59.
http://dx.doi.org/10.1007/BF00253871