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Abstract:

The viscosity of supercooled glycerol aqueous solutions, with glycerol mass fractions between 0.70 and 0.90, have been determined to confirm that the Avramov-Milchev equation describes very well the temperature dependence of the viscosity of the binary mixtures including the supercooled regime. On the contrary, it is shown that the free volume model of viscosity, with the parameters proposed in a recent work (He, Fowler, Toner, J. Appl. Phys. 100 (2006) 074702), overestimates the viscosity of the glycerol-rich mixtures at low temperatures by several orders of magnitude. Moreover, the free volume model for the water diffusion leads to predictions of the Stokes-Einstein product, which are incompatible with the experimental findings. We conclude that the use of these free volume models, with parameters obtained by fitting experimental data far from the supercooled and glassy regions, lead to incorrect predictions of the deterioration rates of biomolecules, overestimating their life times in these cryopreservation media. © 2012 Elsevier Inc.

Registro:

Documento: Artículo
Título:Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation
Autor:Trejo González, J.A.; Paula Longinotti, M.; Corti, H.R.
Filiación:Instituto de Quimica Fisica de los Materiales, Medio Ambiente y Energia (INQUIMAE-CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Departamento de Física de la Materia Condensada, Comisión Nacional de Energía Atómica, Avda. General Paz 1499, 1650 San Martín, Buenos Aires, Argentina
Palabras clave:Diffusion; Glassy state; Glycerol aqueous solutions; Supercooled; Viscosity; glycerol; water; aqueous solution; article; Avramov Milchev equation; controlled study; cooling; cryopreservation; deterioration; diffusion; lifespan; low temperature; mathematical analysis; model; molecule; priority journal; Stokes Einstein equation; supercooling; temperature dependence; validity; viscosity; Cold Temperature; Cryopreservation; Cryoprotective Agents; Diffusion; Glycerol; Models, Chemical; Solutions; Viscosity; Water
Año:2012
Volumen:65
Número:2
Página de inicio:159
Página de fin:162
DOI: http://dx.doi.org/10.1016/j.cryobiol.2012.05.003
Título revista:Cryobiology
Título revista abreviado:Cryobiology
ISSN:00112240
CODEN:CRYBA
CAS:glycerol, 56-81-5; water, 7732-18-5; Cryoprotective Agents; Glycerol, 56-81-5; Solutions; Water, 7732-18-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00112240_v65_n2_p159_TrejoGonzalez

Referencias:

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Citas:

---------- APA ----------
Trejo González, J.A., Paula Longinotti, M. & Corti, H.R. (2012) . Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation. Cryobiology, 65(2), 159-162.
http://dx.doi.org/10.1016/j.cryobiol.2012.05.003
---------- CHICAGO ----------
Trejo González, J.A., Paula Longinotti, M., Corti, H.R. "Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation" . Cryobiology 65, no. 2 (2012) : 159-162.
http://dx.doi.org/10.1016/j.cryobiol.2012.05.003
---------- MLA ----------
Trejo González, J.A., Paula Longinotti, M., Corti, H.R. "Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation" . Cryobiology, vol. 65, no. 2, 2012, pp. 159-162.
http://dx.doi.org/10.1016/j.cryobiol.2012.05.003
---------- VANCOUVER ----------
Trejo González, J.A., Paula Longinotti, M., Corti, H.R. Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation. Cryobiology. 2012;65(2):159-162.
http://dx.doi.org/10.1016/j.cryobiol.2012.05.003