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Romero, M.C.; Zanaro, N.; González, L.; Trigo, P.; Imventarza, O.; Nesse, A. "Tamm-Horsfall protein excretion to predict the onset of renal insufficiency" (2002) Clinical Biochemistry. 35(1):65-68
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Abstract:

Objective: Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. Design and Methods: THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr1) and 20 showed no acute renal damage (LTr2) after liver transplantation. Results: No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were: Controls: 113.2/84.9 to 146.8 mg/24 h (n = 30); LTr1: 36.9/18.3 to 54.5 mg/24 h (p≪0.001 with respect to C and LTr2); LTr2: 90.8/61.5 to 139.7 mg/24 h. Conclusions: The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation. © 2002 The Canadian Society of Clinical Chemists. All rights reserved.

Registro:

Documento: Artículo
Título:Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
Autor:Romero, M.C.; Zanaro, N.; González, L.; Trigo, P.; Imventarza, O.; Nesse, A.
Filiación:Departmento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Cd. Auton. Buenos Aires, Argentina
Hospital General de Agudos Dr. Cosme Argerich, Gobierno de la Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave:Biochemical markers; Immunotherapy; Liver transplantation; Nephrotoxicity; Renal insufficiency; Tamm-Horsfall Protein; creatinine; Tamm Horsfall glycoprotein; adult; aged; article; clinical article; controlled study; creatinine blood level; disease marker; enzyme linked immunosorbent assay; female; human; kidney failure; liver transplantation; male; prediction; priority journal; protein secretion; protein synthesis; urinalysis; urinary excretion; Adolescent; Adult; Aged; Biological Markers; Creatinine; Female; Humans; Immunoassay; Kidney; Kidney Failure; Kidney Transplantation; Male; Middle Aged; Mucoproteins; Time Factors
Año:2002
Volumen:35
Número:1
Página de inicio:65
Página de fin:68
DOI: http://dx.doi.org/10.1016/S0009-9120(02)00274-6
Título revista:Clinical Biochemistry
Título revista abreviado:Clin. Biochem.
ISSN:00099120
CODEN:CLBIA
CAS:Biological Markers; Creatinine, 60-27-5; Mucoproteins; Tamm-Horsfall protein
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099120_v35_n1_p65_Romero

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Citas:

---------- APA ----------
Romero, M.C., Zanaro, N., González, L., Trigo, P., Imventarza, O. & Nesse, A. (2002) . Tamm-Horsfall protein excretion to predict the onset of renal insufficiency. Clinical Biochemistry, 35(1), 65-68.
http://dx.doi.org/10.1016/S0009-9120(02)00274-6
---------- CHICAGO ----------
Romero, M.C., Zanaro, N., González, L., Trigo, P., Imventarza, O., Nesse, A. "Tamm-Horsfall protein excretion to predict the onset of renal insufficiency" . Clinical Biochemistry 35, no. 1 (2002) : 65-68.
http://dx.doi.org/10.1016/S0009-9120(02)00274-6
---------- MLA ----------
Romero, M.C., Zanaro, N., González, L., Trigo, P., Imventarza, O., Nesse, A. "Tamm-Horsfall protein excretion to predict the onset of renal insufficiency" . Clinical Biochemistry, vol. 35, no. 1, 2002, pp. 65-68.
http://dx.doi.org/10.1016/S0009-9120(02)00274-6
---------- VANCOUVER ----------
Romero, M.C., Zanaro, N., González, L., Trigo, P., Imventarza, O., Nesse, A. Tamm-Horsfall protein excretion to predict the onset of renal insufficiency. Clin. Biochem. 2002;35(1):65-68.
http://dx.doi.org/10.1016/S0009-9120(02)00274-6