Artículo
Abstract:
Evidence accumulated over the last decade concerning human and experimental models suggests that an immunopathological mechanism may be involved in the pathogenesis of chronic Chagas' disease. In this paper we demonstrate the existence of two different circulating IgG in chagasic patients which bind with myocardial β1 and spleen cell β2 adrenoceptors, acting as non-competitive inhibitors. Both chagasic IgG against β1 and β2 adrenoceptor increased intracellular levels of cAMP that could be blocked by specific β1 and β2 adrenoceptor antagonist. The specificity for β1 and β2 adrenoceptors and the independence of other tissue reactive antibodies was demonstrated by IgG absorption with turkey red blood cell (TRBC), human lymphocytes (HL) or guinea pig red blood cells (GPRBC). The F(ab')2 fraction acted similarly. This supports the specificity of β1 and β2 adrenoceptors to the chagasic IgG and the independence of the other tissue reactive antibodies, such as EVI system. The probable pathogenic role of both β1 and β2 adrenergic chagasic antibody is discussed.
Registro:
| Documento: | Artículo |
| Título: | Antibodies to β1 and β2 adrenoreceptors in Chagas' disease |
| Autor: | Sterin-Borda, L.; Perez Leiros, C.; Wald, M.; Cremaschi, G.; Borda, E. |
| Filiación: | Centro de Estudios Farmacologicos y de Principios Naturales, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Serrano 665, Buenos Aires, Argentina |
| Palabras clave: | beta 1 adrenergic receptor; beta 2 adrenergic receptor; cyclic amp; dihydroalprenolol; immunoglobulin g; isoprenaline; propranolol; receptor antibody; chagas disease; clinical article; human; priority journal; protozoon; Antibody Specificity; Chagas Cardiomyopathy; Cyclic AMP; Dihydroalprenolol; Dose-Response Relationship, Immunologic; Human; Immunoglobulin G; Immunoglobulins, Fab; Lymphocytes; Myocardium; Receptors, Adrenergic, beta; Spleen; Time Factors |
| Año: | 1988 |
| Volumen: | 74 |
| Número: | 3 |
| Página de inicio: | 349 |
| Página de fin: | 354 |
| Título revista: | Clinical and Experimental Immunology |
| Título revista abreviado: | CLIN. EXP. IMMUNOL. |
| ISSN: | 00099104 |
| CODEN: | CEXIA |
| CAS: | cyclic AMP, 60-92-4; dihydroalprenolol, 60106-89-0; immunoglobulin G, 97794-27-9; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Cyclic AMP, 60-92-4; Dihydroalprenolol, 60106-89-0; Immunoglobulin G; Immunoglobulins, Fab; Receptors, Adrenergic, beta |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v74_n3_p349_SterinBorda |
Citas:
---------- APA ----------
Sterin-Borda, L., Perez Leiros, C., Wald, M., Cremaschi, G. & Borda, E. (1988) . Antibodies to β1 and β2 adrenoreceptors in Chagas' disease. Clinical and Experimental Immunology, 74(3), 349-354.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v74_n3_p349_SterinBorda [ ]
---------- CHICAGO ----------
Sterin-Borda, L., Perez Leiros, C., Wald, M., Cremaschi, G., Borda, E. "Antibodies to β1 and β2 adrenoreceptors in Chagas' disease" . Clinical and Experimental Immunology 74, no. 3 (1988) : 349-354.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v74_n3_p349_SterinBorda [ ]
---------- MLA ----------
Sterin-Borda, L., Perez Leiros, C., Wald, M., Cremaschi, G., Borda, E. "Antibodies to β1 and β2 adrenoreceptors in Chagas' disease" . Clinical and Experimental Immunology, vol. 74, no. 3, 1988, pp. 349-354.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v74_n3_p349_SterinBorda [ ]
---------- VANCOUVER ----------
Sterin-Borda, L., Perez Leiros, C., Wald, M., Cremaschi, G., Borda, E. Antibodies to β1 and β2 adrenoreceptors in Chagas' disease. CLIN. EXP. IMMUNOL. 1988;74(3):349-354.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v74_n3_p349_SterinBorda [ ]
