Artículo
Abstract:
In autoimmune myocarditis significant alterations in contractility when the heart is studied in vitro could be demonstrated. The isolated atria from mice hyperimmunized with heart exhibited tachycardia, decrease in contractility and dysrhythmia. Spleen lymphocytes from mice with autoimmune myocarditis, can react in vitro with spontaneously beating normal atria inducing dysrhythmias and negative inotropic effect. The alterations in contractility of normal atria induced by immune cells, resemble those observed in atria from animals with autoimmune myocarditis. The use of pharmacologic inhibitors strongly suggests that the cardiac dysfunction is generated by the release of endogenous SRS-A as a result of the hyperimmunization with heart. The possibility that autoimmune lymphocyte can influence the contractile behaviour of the heart is interesting and could provide some evidence for the role of lymphocytic infiltration in the mechanism operating in primary and specific myocarditis.
Registro:
| Documento: | Artículo |
| Título: | Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction |
| Autor: | Leiros, C.P.; Sterin-Borda, L.; Cossio, P. |
| Filiación: | CEFAPRIN (Conicet), 1428 Buenos Aires, Argentina |
| Palabras clave: | animal experiment; autoimmune disease; dysrhythmia; etiology; heart; heart disease; lymphocytic infiltration; mouse; myocarditis; nonhuman; priority journal; tachycardia; Animal; Autoimmune Diseases; Cell Movement; Disease Models, Animal; Heart Atrium; Lymphocytes; Mice; Myocardial Contraction; Myocarditis; Myocardium; Spleen; Support, Non-U.S. Gov't; Time Factors |
| Año: | 1986 |
| Volumen: | 63 |
| Número: | 3 |
| Página de inicio: | 648 |
| Página de fin: | 655 |
| Título revista: | Clinical and Experimental Immunology |
| Título revista abreviado: | CLIN. EXP. IMMUNOL. |
| ISSN: | 00099104 |
| CODEN: | CEXIA |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v63_n3_p648_Leiros |
Citas:
---------- APA ----------
Leiros, C.P., Sterin-Borda, L. & Cossio, P. (1986) . Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction. Clinical and Experimental Immunology, 63(3), 648-655.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v63_n3_p648_Leiros [ ]
---------- CHICAGO ----------
Leiros, C.P., Sterin-Borda, L., Cossio, P. "Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction" . Clinical and Experimental Immunology 63, no. 3 (1986) : 648-655.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v63_n3_p648_Leiros [ ]
---------- MLA ----------
Leiros, C.P., Sterin-Borda, L., Cossio, P. "Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction" . Clinical and Experimental Immunology, vol. 63, no. 3, 1986, pp. 648-655.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v63_n3_p648_Leiros [ ]
---------- VANCOUVER ----------
Leiros, C.P., Sterin-Borda, L., Cossio, P. Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction. CLIN. EXP. IMMUNOL. 1986;63(3):648-655.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v63_n3_p648_Leiros [ ]
