Artículo
Sterin-Borda, L.; Cremaschi, G.; Pascual, J. "Alloimmune IgG binds and modulates cardiac β-adrenoceptor activity" (1984) Clinical and Experimental Immunology. 58(1):223-228
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Abstract:
Purified IgG from murine alloimmune sera directed against class I products from the major histocompatibility complex of the mouse, could bind to the β-adrenoceptors and stimulate contractile activity of myocardium. Immune IgG inhibited the binding of (-)3H-DHA to β-adrenoceptors of mouse myocardial membranes behaving as a competitive inhibitor. Moreover, immune IgG induced positive inotropic and chronotropic effects on isolated mouse atria. These effects could be blocked by β-adrenoceptors antagonists. Data prove that immune IgG directed against specific alloantigens are able to recognize the β-adrenoceptors and mimic the stimulation of the β-adrenoceptor agonist.
Registro:
| Documento: | Artículo |
| Título: | Alloimmune IgG binds and modulates cardiac β-adrenoceptor activity |
| Autor: | Sterin-Borda, L.; Cremaschi, G.; Pascual, J. |
| Filiación: | Centro de Estudios Farmacologicos y de Principios Naturales, 1414 Buenos Aires, Argentina |
| Palabras clave: | alloantibody; beta adrenergic receptor; butoxamine; immunoglobulin g; practolol; radioisotope; 4 oxyprenolol; animal cell; dihydroalprenolol h 3; drug efficacy; heart; heart muscle; inotropism; mouse; nonhuman; Animal; Atrial Function; Binding, Competitive; Dose-Response Relationship, Immunologic; Heart Atrium; Immunoglobulin G; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Myocardial Contraction; Myocardium; Receptors, Adrenergic, beta; Stimulation, Chemical; Support, Non-U.S. Gov't |
| Año: | 1984 |
| Volumen: | 58 |
| Número: | 1 |
| Página de inicio: | 223 |
| Página de fin: | 228 |
| Título revista: | Clinical and Experimental Immunology |
| Título revista abreviado: | CLIN. EXP. IMMUNOL. |
| ISSN: | 00099104 |
| CODEN: | CEXIA |
| CAS: | butoxamine, 1937-89-9; immunoglobulin G, 97794-27-9; practolol, 6673-35-4; Immunoglobulin G; Receptors, Adrenergic, beta |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v58_n1_p223_SterinBorda |
Citas:
---------- APA ----------
Sterin-Borda, L., Cremaschi, G. & Pascual, J. (1984) . Alloimmune IgG binds and modulates cardiac β-adrenoceptor activity. Clinical and Experimental Immunology, 58(1), 223-228.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v58_n1_p223_SterinBorda [ ]
---------- CHICAGO ----------
Sterin-Borda, L., Cremaschi, G., Pascual, J. "Alloimmune IgG binds and modulates cardiac β-adrenoceptor activity" . Clinical and Experimental Immunology 58, no. 1 (1984) : 223-228.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v58_n1_p223_SterinBorda [ ]
---------- MLA ----------
Sterin-Borda, L., Cremaschi, G., Pascual, J. "Alloimmune IgG binds and modulates cardiac β-adrenoceptor activity" . Clinical and Experimental Immunology, vol. 58, no. 1, 1984, pp. 223-228.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v58_n1_p223_SterinBorda [ ]
---------- VANCOUVER ----------
Sterin-Borda, L., Cremaschi, G., Pascual, J. Alloimmune IgG binds and modulates cardiac β-adrenoceptor activity. CLIN. EXP. IMMUNOL. 1984;58(1):223-228.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v58_n1_p223_SterinBorda [ ]
