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De Viale, L.C.S.M.; De Calmanovici, R.W.; De Molina, M.D.C.R.; Grinstein, M. "Studies on porphyrin biosynthesis in lead-intoxicated rabbits" (1976) Clinica Chimica Acta. 69(3):375-382
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Abstract:

The present report deals with studies on porphyrins and porphyrinogen carboxylyase of red cells and urinary porphyrins from lead-intoxicated rabbits. It was shown that the free erythrocyte porphyrins are a mixture of protoporphyrin 9, the main component, and minor proportions of Coproporphyrin, Uroporphyrin III and Phyriaporphyrin. Analysis of the urinary porphyrins demonstrates the presence of Coproporphyrin III as the major component, together with 15-20% of other porphyrins: 10-14% 5-COOH, 1-2% 6-COOH, 2-3% 7-COOH porphyrin and 1-2% Uroporphyrin III. We have not been able to detect an increase of Uroporphyrin I. Assays of porphyrinogen carboxy-lyase activity in hemolysate supernatant using Uroporphyrinogen III and Phyriaporphyrinogen (Phyria'gen) III as substrates, showed the existence of a slight decrease of both decarboxylase activities, being more affected during the second stage, the Phyria'gen decarboxylation. A possible regulation mechanism responsible for the porphyrin picture is discussed. © 1976.

Registro:

Documento: Artículo
Título:Studies on porphyrin biosynthesis in lead-intoxicated rabbits
Autor:De Viale, L.C.S.M.; De Calmanovici, R.W.; De Molina, M.D.C.R.; Grinstein, M.
Filiación:Laboratorio de Porfirinas, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, 4 piso, Ciudad Universitaria, Núñez, Buenos Aires Argentina
Palabras clave:porphyrin; uroporphyrinogen decarboxylase; in vitro study; lead poisoning; theoretical study; Animal; Erythrocytes; Female; Lead Poisoning; Male; Porphyrinogens; Porphyrins; Rabbits; Uroporphyrinogen Decarboxylase
Año:1976
Volumen:69
Número:3
Página de inicio:375
Página de fin:382
DOI: http://dx.doi.org/10.1016/0009-8981(76)90108-X
Título revista:Clinica Chimica Acta
Título revista abreviado:Clin. Chim. Acta
ISSN:00098981
CODEN:CCATA
CAS:porphyrin, 24869-67-8; uroporphyrinogen decarboxylase, 9024-70-8; Porphyrinogens; Porphyrins; Uroporphyrinogen Decarboxylase, EC 4.1.1.37
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v69_n3_p375_DeViale

Referencias:

  • Haeger-Aronson, (1960) Scand. J. Clin. Lab. Invest., 126
  • Chisolm, (1964) J. Pediatr., 64, p. 174
  • Kreimer-Birnbaum, Grinstein, (1965) Biochim. Biophys. Acta, 111, p. 110
  • Garcia, San Martín de Viale, Tomio, Grinstein, (1973) Biochim. Biophys. Acta, 309, p. 203
  • Aragones, Garcia, San Martín de Viale, Tomio, Grinstein, (1972) An. Asoc. Quim. Arg., 60, p. 239
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  • Tomio, Garcia, San Martín de Viale, Grinstein, (1970) Biochim. Biophys. Acta, 198, p. 353
  • Mauzerall, Granick, (1958) J. Biol. Chem., 232, p. 1141
  • Schmid, Hanson, Schwarz, Experimental Porphyria. I. Isolation of Uroporphyrin I from Bone Marrow of Lead Poisoned Rabbits. (1952) Experimental Biology and Medicine, 79, p. 459
  • Steiner, Baldini, Dameshek, (1964) Ann. N.Y. Acad. Sci., 119, p. 548
  • Doss, (1973) Enzymes, 16, p. 231

Citas:

---------- APA ----------
De Viale, L.C.S.M., De Calmanovici, R.W., De Molina, M.D.C.R. & Grinstein, M. (1976) . Studies on porphyrin biosynthesis in lead-intoxicated rabbits. Clinica Chimica Acta, 69(3), 375-382.
http://dx.doi.org/10.1016/0009-8981(76)90108-X
---------- CHICAGO ----------
De Viale, L.C.S.M., De Calmanovici, R.W., De Molina, M.D.C.R., Grinstein, M. "Studies on porphyrin biosynthesis in lead-intoxicated rabbits" . Clinica Chimica Acta 69, no. 3 (1976) : 375-382.
http://dx.doi.org/10.1016/0009-8981(76)90108-X
---------- MLA ----------
De Viale, L.C.S.M., De Calmanovici, R.W., De Molina, M.D.C.R., Grinstein, M. "Studies on porphyrin biosynthesis in lead-intoxicated rabbits" . Clinica Chimica Acta, vol. 69, no. 3, 1976, pp. 375-382.
http://dx.doi.org/10.1016/0009-8981(76)90108-X
---------- VANCOUVER ----------
De Viale, L.C.S.M., De Calmanovici, R.W., De Molina, M.D.C.R., Grinstein, M. Studies on porphyrin biosynthesis in lead-intoxicated rabbits. Clin. Chim. Acta. 1976;69(3):375-382.
http://dx.doi.org/10.1016/0009-8981(76)90108-X