Abstract:
Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n = 122; males = 60; mean age = 73 ± 7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD + DM, VaD + DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate. Results: The one-way ANOVA yielded significant differences between groups for all variables: tHcy p < 10-12; B12 p < 10-3; FOL p < 10-4. Significance for comparisons between groups was set at α = 0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD + DM vs. AD, VaD + DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons. Conclusions: In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias. © 2005 Elsevier B.V. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition |
Autor: | Domínguez, R.O.; Marschoff, E.R.; Guareschi, E.M.; Famulari, A.L.; Pagano, M.A.; Serra, J.A. |
Filiación: | Facultad de Medicina, Hospital Sirio-Libanés-UBA, FACENE, Buenos Aires, Argentina Facultad de Ciencias Exactas Y Naturales, UBA, Argentina Laboratorio Especializado para Las Investigaciones, Clínicas (LEPLIC), Buenos Aires, Argentina Facultad de Medicina, Hospital Juan A. Fernández, UBA, Argentina Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET)-PRALIB, Facultad de Farmacia Y Bioquímica, UBA, Argentina Lab. Biomembranas Y Canales Iónicos, Cátedra Química General e Inorgánica, Facultad Farmacia Y Bioquímica (U.B.A.), Junín 954, C1113AAD Buenos Aires, Argentina
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Palabras clave: | Dementia of the Alzheimer's type; Dementia risk factors; Folate; Homocysteine; Non-insulin-dependent type II diabetes mellitus; Vascular dementia; Vitamin B 12; cyanocobalamin; folic acid; homocysteine; aged; Alzheimer disease; article; blood level; blood sampling; controlled study; female; human; male; multiinfarct dementia; non insulin dependent diabetes mellitus; priority journal; risk factor; sample size; statistical analysis; Aged; Alzheimer Disease; Analysis of Variance; Dementia, Vascular; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 |
Año: | 2005
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Volumen: | 359
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Número: | 1-2
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Página de inicio: | 163
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Página de fin: | 170
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DOI: |
http://dx.doi.org/10.1016/j.cccn.2005.03.049 |
Título revista: | Clinica Chimica Acta
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Título revista abreviado: | Clin. Chim. Acta
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ISSN: | 00098981
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CODEN: | CCATA
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CAS: | cyanocobalamin, 53570-76-6, 68-19-9, 8064-09-3; folic acid, 59-30-3, 6484-89-5; homocysteine, 454-28-4, 6027-13-0; Folic Acid, 59-30-3; Homocysteine, 454-28-4; Vitamin B 12, 68-19-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v359_n1-2_p163_Dominguez |
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Citas:
---------- APA ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A. & Serra, J.A.
(2005)
. Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition. Clinica Chimica Acta, 359(1-2), 163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049---------- CHICAGO ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A.
"Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition"
. Clinica Chimica Acta 359, no. 1-2
(2005) : 163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049---------- MLA ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A.
"Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition"
. Clinica Chimica Acta, vol. 359, no. 1-2, 2005, pp. 163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049---------- VANCOUVER ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A. Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition. Clin. Chim. Acta. 2005;359(1-2):163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049