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Abstract:

Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n = 122; males = 60; mean age = 73 ± 7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD + DM, VaD + DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate. Results: The one-way ANOVA yielded significant differences between groups for all variables: tHcy p < 10-12; B12 p < 10-3; FOL p < 10-4. Significance for comparisons between groups was set at α = 0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD + DM vs. AD, VaD + DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons. Conclusions: In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias. © 2005 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
Autor:Domínguez, R.O.; Marschoff, E.R.; Guareschi, E.M.; Famulari, A.L.; Pagano, M.A.; Serra, J.A.
Filiación:Facultad de Medicina, Hospital Sirio-Libanés-UBA, FACENE, Buenos Aires, Argentina
Facultad de Ciencias Exactas Y Naturales, UBA, Argentina
Laboratorio Especializado para Las Investigaciones, Clínicas (LEPLIC), Buenos Aires, Argentina
Facultad de Medicina, Hospital Juan A. Fernández, UBA, Argentina
Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET)-PRALIB, Facultad de Farmacia Y Bioquímica, UBA, Argentina
Lab. Biomembranas Y Canales Iónicos, Cátedra Química General e Inorgánica, Facultad Farmacia Y Bioquímica (U.B.A.), Junín 954, C1113AAD Buenos Aires, Argentina
Palabras clave:Dementia of the Alzheimer's type; Dementia risk factors; Folate; Homocysteine; Non-insulin-dependent type II diabetes mellitus; Vascular dementia; Vitamin B 12; cyanocobalamin; folic acid; homocysteine; aged; Alzheimer disease; article; blood level; blood sampling; controlled study; female; human; male; multiinfarct dementia; non insulin dependent diabetes mellitus; priority journal; risk factor; sample size; statistical analysis; Aged; Alzheimer Disease; Analysis of Variance; Dementia, Vascular; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12
Año:2005
Volumen:359
Número:1-2
Página de inicio:163
Página de fin:170
DOI: http://dx.doi.org/10.1016/j.cccn.2005.03.049
Título revista:Clinica Chimica Acta
Título revista abreviado:Clin. Chim. Acta
ISSN:00098981
CODEN:CCATA
CAS:cyanocobalamin, 53570-76-6, 68-19-9, 8064-09-3; folic acid, 59-30-3, 6484-89-5; homocysteine, 454-28-4, 6027-13-0; Folic Acid, 59-30-3; Homocysteine, 454-28-4; Vitamin B 12, 68-19-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v359_n1-2_p163_Dominguez

Referencias:

  • Seshadri, S., Beiser, A., Selhub, J., Jacques, P.F., Rosenberg, I.H., D'Agostino, R.B., Plasma homocysteine as a risk factor for dementia and Alzheimer's disease (2002) N Engl J Med, 346 (7), pp. 476-483
  • Wang, H.X., Wahlin, A., Basun, H., Fastbom, J., Winblad, B., Fratiglioni, L., Vitamin B(12) and folate in relation to the development of Alzheimer's disease (2001) Neurology, 56 (9), p. 118
  • Quadri, P., Fragiacomo, C., Pezzati, R., Zanda, E., Forloni, G., Tettamanti, M., Homocysteine, folate and vitamin B-12 in mild cognitive impairment, Alzheimer disease and vascular dementia (2004) Am J Clin Nutr, 80, pp. 114-122
  • Luchsinger, J.A., Tang, M.X., Shea, S., Miller, J., Green, R., Mayeux, R., Plasma homocysteine concentration and risk of Alzheimer disease (2004) Neurology, 62 (11), pp. 1972-1976
  • Hernández, L.V., Toledo, B.I., Sánchez, A.F., López, L.G., Vadillo, B.M., Homocisteína y enfermedad vascular en diabetes mellitus tipo 2 (2001) Rev Endocrinol Nutr, 9 (4), pp. 170-175
  • Rogers, J.D., Sanchez-Saffon, A., Frol, A.B., Diaz-Arrastia, R., Elevated plasma homocysteine concentration in patients treated with levodopa: Association with vascular disease (2003) Arch Neurol, 60 (1), pp. 59-64
  • Postuma, R.B., Lang, A.E., Homocysteine and levodopa: Should Parkinson disease patients receive preventive therapy? (2004) Neurology, 63 (5), pp. 886-891
  • Tessari, P., Kiwanuka, E., Coracina, A., Zaramella, M., Vettore, M., Valerio, A., Insulin in methionine and homocysteine kinetics in healthy humans: Plasma vs. intracellular models (2005) Am J Physiol Endocrinol Metab, 288 (6), pp. 1270-E1276
  • Buysschaert, M., Gala, J.L., Bessomo, A., Hermans, M.P., C677T methylene-tetrahydrofolate reductase mutation in type 2 diabetic patients with and without hyperhomocysteinaemia (2004) Diabetes Metab, 30 (4), pp. 349-354
  • Mc Khan, G., Drachman, D., Folstein, M., Katzman, R., Price, C., Stardlan, M., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force of Alzheimer's disease (1984) Neurology, 34, pp. 939-944
  • Roman, G.C., Tatemichi, T.K., Erkinjuntti, T., Cummings, J.L., Masdeu, J.C., Garcia, J.H., Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop (1993) Neurology, 43, pp. 250-260
  • Report of the expert committee on the diagnosis and classification of diabetes mellitus (2000) Diabetes Care, 23, pp. 4-S19. , The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
  • (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM IV), , American Psychiatric Association fourth ed. American Psychiatric Association Washington
  • Mattis, S., Mental status examination for organic mental syndrome in the elderly patient (1976) Geriatric Psychiatry: A Handbook for Psychiatrists and Primary Care Physicians, pp. 77-101. , L. Bellak T. Karasu Grune and Stratton New York
  • Schwarb, S., Koberle, S., Spiegel, R., The Alzheimer's Disease Assessment Scale (ADAS): An instrument for early diagnosis of dementia? (1988) Int J Geriatr Psychiatry, 3, pp. 45-53
  • Hughes, C.P., Berg, L., Danziger, W.L., Coban, L.A., Martin, R.L., A new clinical scale for the staging of dementia (CDR) (1982) Br J Psychiatry, 140, pp. 566-572
  • Hamilton, M.A., Rating scale for depression (1960) J Neurol Neurosurg Psychiatry, 23, pp. 56-62
  • Serra, J.A., Marschoff, E.R., Domínguez, R.O., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition (2004) J Neurol Sci, 218, pp. 17-24
  • Shipchandler, M.T., Moore, E.G., Rapid, fully automated measurement of plasma homocysteine with the Abbott IMx analyzer (1995) Clin Chem, 41, pp. 991-994
  • Wilson, D.H., Yu, J., Karian, A., Kozlowski, J., O'Reilly, S., Development and multisite evaluation of an automated assay for B12 on the Abbott AxSYM analyzer (1999) Clin Chem, 45, pp. 428-429
  • Manzella, S., Gronowski, A., Ladenson, J., Scott, M.G., Limited linear range of the Abbott AxSYM serum and erythrocyte folate methods (1999) Clin Chem, 45, pp. 582-583
  • Sokal, R.R., Rohlf, F.J., (1995) Biometry, , third ed. Freeman WH and Company New York
  • Garcia, A., Zanibbi, K., Homocysteine and cognitive function in elderly people (2004) CMAJ, 171 (8), pp. 897-904
  • Hofman, A., Ott, A., Breteler, M.M., Bots, M.L., Slooter, A.J., Van Harskamp, F., Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam study (1997) Lancet, 349, pp. 151-154
  • Breteler, M.M., Vascular risk factors for Alzheimer's disease: An epidemiologic perspective (2000) Neurobiol Aging, 21, pp. 153-160
  • Snowdon, D.A., Greiner, L.H., Mortimer, J.A., Riley, K.P., Greiner, P.A., Markesbery, W.R., Brain infarction and the clinical expression of Alzheimer disease: The Nun study (1997) JAMA, 277 (10), pp. 813-817
  • Hayden, M.R., Tyagi, S.C., Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: The pleiotropic effects of folate supplementation (2004) Nutr J, 3 (1), p. 4
  • Widner, B., Leblhuber, F., Frick, B., Laich, A., Artner-Dworzak, E., Fuchs, D., Moderate hyperhomocysteinaemia and immune activation in Parkinson's disease (2002) J Neural Transm, 109 (12), pp. 1445-1452
  • Fuchs, D., Jaeger, M., Widner, B., Wirleitner, B., Artner-Dworzak, E., Leblhuber, F., Is hyperhomocysteinaemia due to oxidative depletion of folate rather than to insufficient dietary intake? (2001) Clin Chem Med, 39, pp. 691-694
  • Widner, B., Enzinger, C., Laich, A., Wirleitner, B., Fuchs, D., Hyperhomocysteinemia, pteridines and oxidative stress (2002) Curr Drug Metab, 3, pp. 225-232
  • Serra, J.A., Domínguez, R.O., De Lustig, E.S., Guareschi, E.M., Famulari, A.L., Bartolomé, E.L., Parkinson's disease is associated with oxidative profiles in living Parkinson's, Alzheimer's and vascular dementia patients (2001) J Neural Transm, 108, pp. 1135-1148

Citas:

---------- APA ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A. & Serra, J.A. (2005) . Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition. Clinica Chimica Acta, 359(1-2), 163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049
---------- CHICAGO ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A. "Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition" . Clinica Chimica Acta 359, no. 1-2 (2005) : 163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049
---------- MLA ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A. "Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition" . Clinica Chimica Acta, vol. 359, no. 1-2, 2005, pp. 163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049
---------- VANCOUVER ----------
Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A. Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition. Clin. Chim. Acta. 2005;359(1-2):163-170.
http://dx.doi.org/10.1016/j.cccn.2005.03.049